nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2008-12-2-36-38nefr-1048Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESКАРДИОВАСКУЛЯРНЫЕ ЭФФЕКТЫ АЛЬДОСТЕРОНАCARDIOVASCULAR EFFECTS OF ALDOSTERONEКарабаеваА. Ж.KarabaevaA. Zh.

Кафедра нефрологии и диализа факультета последипломного обучения 

ЕсаянА. М.EssaianA. M.

Кафедра нефрологии и диализа факультета последипломного обучения

КаюковИ. Г.KayukovI. G.

Кафедра нефрологии и диализа факультета последипломного обучения

197022,  Санкт-Петербург, тел.:  (812)-34639-26,  факс:  (812)-234-91-91 

kaukov@nephrolog.ruСанкт-Петербургский государственный медицинский университет им. акад. И.П. ПавловаRussian Federation2008100220081223638Copyright © Карабаева А.Ж., Есаян А.М., Каюков И.Г., 20082008Карабаева А.Ж., Есаян А.М., Каюков И.Г.Karabaeva A.Z., Essaian A.M., Kayukov I.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1048

В статье содержатся сведения об эффектах альдостерона при связывании с эпителиальными и неэпителиальными минералкортикоидными рецепторами, а также показана патофизиологическая роль данного стероидного гормона в развитии и кардиоваскулярных осложнений при хронической болезни почек. Приведены данные экспериментальных и клинических исследований, доказывающих способность альдостерона вызывать фиброз миокарда и сосудов.

The work contains data of the effects of aldosterone when binding with epithelial and non-epithelial mineral corticoid receptors. The pathophysiological role of this steroid hormone is shown in the development of cardiovascular complications in chronic diseases of the kidneys as well. The data of experimental and clinical investigations are presented demonstrating the ability of aldosterone to cause fibrosis of the myocardium and vessels

альдостеронэпителиальные и неэпителиальные минералкортикоидные рецепторыфиброз миокардаaldosteroneepithelial and non-epithelial mineral corticoid receptorsmyocardium fibrosisReferencesChrist M, Douwes K, Eisen C et al. Rapid non-genomic effects of aldosterone on sodium transport in rat vascular smooth muscle cells: involvement of the Na+ / H+ antiport. Hypertension 1995; 25: 117-123Christ M, Douwes K, Eisen C et al. Rapid non-genomic effects of aldosterone on sodium transport in rat vascular smooth muscle cells: involvement of the Na+ / H+ antiport. Hypertension 1995; 25: 117-123Camargo MJ, von Lutterotti N, Campbell JrWG et al. Control of blood pressure and end-organ damage in maturing salt-loaded stroke-prone spontaneously hypertensive rats by oral angiotensin II receptor blockade. J Hypertens 1993; 11: 31–40Camargo MJ, von Lutterotti N, Campbell JrWG et al. Control of blood pressure and end-organ damage in maturing salt-loaded stroke-prone spontaneously hypertensive rats by oral angiotensin II receptor blockade. J Hypertens 1993; 11: 31–40Duprez D, de Buyzere M, Rietzchel ER, Clement DL. Aldosterone and vascular damage. Curr Hypertens Rep 2000; 2; 327-334Duprez D, de Buyzere M, Rietzchel ER, Clement DL. Aldosterone and vascular damage. Curr Hypertens Rep 2000; 2; 327-334Epstein M. Aldosterone receptor blockade and the role of eplerenone: evolving perspectives. Nephrol Dial Transpl 2003; 18: 1984-1992Epstein M. Aldosterone receptor blockade and the role of eplerenone: evolving perspectives. Nephrol Dial Transpl 2003; 18: 1984-1992Foster RH, MacFarlane CH, Bustamante MO. Recent progress in understanding aldosterone secretion. Gen Pharmacol 1997; 28: 647-651Foster RH, MacFarlane CH, Bustamante MO. Recent progress in understanding aldosterone secretion. Gen Pharmacol 1997; 28: 647-651Fuller PJ. Aldosterone’s effects and mechanism of action. Curr Opin Endocrinol Diabetes 1997; 4: 218-224Fuller PJ. Aldosterone’s effects and mechanism of action. Curr Opin Endocrinol Diabetes 1997; 4: 218-224Ebata S, Muto S, Okada K et al. Aldosterone activates Na+ / H+ exchange in vascular smooth muscle cells by non-genomic and genomic mechanisms. Kidney Int 1999; 56: 1400-1412Ebata S, Muto S, Okada K et al. Aldosterone activates Na+ / H+ exchange in vascular smooth muscle cells by non-genomic and genomic mechanisms. Kidney Int 1999; 56: 1400-1412Gekle M, Freudinger R, Mildenberger S, Silbernagl S. Rapid actions of aldosterone on cells from renal epithelium: the possible role of EGF-receptor signaling. Steroids 2002; 67: 499–504Gekle M, Freudinger R, Mildenberger S, Silbernagl S. Rapid actions of aldosterone on cells from renal epithelium: the possible role of EGF-receptor signaling. Steroids 2002; 67: 499–504Halimi J-M, Mimram A. Albuminuria in untreated patients with primary aldosteronism or essential hypertension. J Hypertens 1995; 13: 1801–1802Halimi J-M, Mimram A. Albuminuria in untreated patients with primary aldosteronism or essential hypertension. J Hypertens 1995; 13: 1801–1802Jalil JE, Janicki JS, Pick R, Weber KT. Coronary vascular remodeling and myocardial fibrosis in the rat with renovascular hypertension: response to captopril. Am J Hypertens 1991; 4: 51–55Jalil JE, Janicki JS, Pick R, Weber KT. Coronary vascular remodeling and myocardial fibrosis in the rat with renovascular hypertension: response to captopril. Am J Hypertens 1991; 4: 51–55Karin M. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell 1998; 93: 487-490Karin M. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell 1998; 93: 487-490Laragh JH, Sealy JE. The renin-angiotensin-aldosterone system in hypertensive disorders: a key to two forms of arteriolar constriction and a possible clue to risk of vascular injury (heart attack and stroke) and prognosis. In: Laragh JH, Brenner BM (eds) Hypertension1990; Pathophysiology, Diagnosis, and Management. Raven Press, New York, 1329-1348Laragh JH, Sealy JE. The renin-angiotensin-aldosterone system in hypertensive disorders: a key to two forms of arteriolar constriction and a possible clue to risk of vascular injury (heart attack and stroke) and prognosis. In: Laragh JH, Brenner BM (eds) Hypertension1990; Pathophysiology, Diagnosis, and Management. Raven Press, New York, 1329-1348Nishimura M, Uzu T, Fuji T et al. Cardiovascular complications in patients with primary aldosteronism. Am J Kidney Dis 1999; 33: 261-266Nishimura M, Uzu T, Fuji T et al. Cardiovascular complications in patients with primary aldosteronism. Am J Kidney Dis 1999; 33: 261-266Pitt B, Zannad F, Remme WJ et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341:709-717Pitt B, Zannad F, Remme WJ et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341:709-717Rossi GP, Sachetto A, Visentin P et al. Changes in left ventricular anatomy and function in hypertension and primary aldosteronism. Hypertension 1996; 27: 1039-1045Rossi GP, Sachetto A, Visentin P et al. Changes in left ventricular anatomy and function in hypertension and primary aldosteronism. Hypertension 1996; 27: 1039-1045Rocha R, Martin-Berger CL, Yang P et al. Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart. Endocrinology 2002; 143: 4828-4836Rocha R, Martin-Berger CL, Yang P et al. Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart. Endocrinology 2002; 143: 4828-4836Stier Jr CT, Chander PN, Gutstein WH et al. Therapeutic benefit of captopril in salt-loaded stroke-prone spontaneously hypertensive rats is independent of hypotensive effect. Am J Hypertens 1991; 4: 680-687Stier Jr CT, Chander PN, Gutstein WH et al. Therapeutic benefit of captopril in salt-loaded stroke-prone spontaneously hypertensive rats is independent of hypotensive effect. Am J Hypertens 1991; 4: 680-687Stier Jr CT, Adler LA, Levine S, Chander PN. Stroke prevention by losartan in stroke-prone spontaneously hypertensive rats. J Hypertens 1993; 11 [Suppl 3]: S37-S42Stier Jr CT, Adler LA, Levine S, Chander PN. Stroke prevention by losartan in stroke-prone spontaneously hypertensive rats. J Hypertens 1993; 11 [Suppl 3]: S37-S42Silvestre J-S, Heymes C, Oubenaisso A et al. Activation of cardiac aldosterone production in rat myocardial infarction. Effect of angiotensin II receptor blockade and role in cardiac fibrosis. Circulation 1999; 99: 2694-2701Silvestre J-S, Heymes C, Oubenaisso A et al. Activation of cardiac aldosterone production in rat myocardial infarction. Effect of angiotensin II receptor blockade and role in cardiac fibrosis. Circulation 1999; 99: 2694-2701Schiffrin EL, Franks DJ, Gutkowska J. Effect of aldosterone on vascular angiotensin II reseptors in the rat. Can J Physiol Pharmacol 1985; 63: 1522-1527Schiffrin EL, Franks DJ, Gutkowska J. Effect of aldosterone on vascular angiotensin II reseptors in the rat. Can J Physiol Pharmacol 1985; 63: 1522-1527Takeda R, Matsubara T, Miyamori I et al. Research Committee of Disorders of Adrenal Hormones in Japan. Vascular complications in patients with aldosterone producing adenoma in Japan: comparative study with essential hypertension. J Endocrinol Invest 1995; 18: 370-373Takeda R, Matsubara T, Miyamori I et al. Research Committee of Disorders of Adrenal Hormones in Japan. Vascular complications in patients with aldosterone producing adenoma in Japan: comparative study with essential hypertension. J Endocrinol Invest 1995; 18: 370-373Wehling M. Non-genomic actions of steroid hormones. Trends Endocrinol Metab 1994; 5: 347-353Wehling M. Non-genomic actions of steroid hormones. Trends Endocrinol Metab 1994; 5: 347-353Wehling M, Neylon CB, Fullerton M et al. Non-genomic effects of aldosterone on intracellular calcium in vascular smooth muscle cells. Circ Res 1995; 76: 973-979Wehling M, Neylon CB, Fullerton M et al. Non-genomic effects of aldosterone on intracellular calcium in vascular smooth muscle cells. Circ Res 1995; 76: 973-979Wehling M, Spes CH, Win N et al. Rapid cardiovascular action of aldosterone in man. J Clin Endocrinol Metab 1998; 83: 3517-3522Wehling M, Spes CH, Win N et al. Rapid cardiovascular action of aldosterone in man. J Clin Endocrinol Metab 1998; 83: 3517-3522Rocha R, Stier CTJ, Kifor I et al. Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. Endocrinology 2000; 141: 3871-3878Rocha R, Stier CTJ, Kifor I et al. Aldosterone: a mediator of myocardial necrosis and renal arteriopathy. Endocrinology 2000; 141: 3871-3878Connell JMC, Davies E. The new biology of aldosterone. Journal of Endocrinology 2005; 186: 1-20Connell JMC, Davies E. The new biology of aldosterone. Journal of Endocrinology 2005; 186: 1-20

The authors declare that there are no conflicts of interest present.