nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical Universitynefr-105Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESАДАПТАЦИОННЫЕ ПРОЦЕССЫ В КОСТНОЙ ТКАНИ -ЭЛЕМЕНТ ПАТОГЕНЕЗА НАРУШЕНИЙ МИНЕРАЛЬНОГО И КОСТНОГО ОБМЕНА ПРИ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕКBONE TISSUE ADAPTATION PROCESSES AS AN ELEMENT OF DISORDERS MINERAL AND BONE METABOLISM PATHOGENESIS IN CHRONIC KIDNEY DISEASEАврунинА. С.AvruninA. S.a_avrunin@mail.ruЛеонтьеваН. В.LeontyevaN. V.noemail@neicon.ruДокторовА. А.DoctorovA. A.noemail@neicon.ruРоссийский научно-исследовательский институт травматологии и ортопедии им. РР ВреденаРоссияRussian Scientific research Institute of traumatology and orthopedics R.R.VredenRussian FederationСеверо-Западный государственный медицинский университет им. И.И. МечниковаРоссияNorth-Western State Medical University I. I. MechnikovRussian FederationГосударственное научное учреждение Всероссийский институт лекарственных и ароматических растений (ГНУ ВИЛАР) РоссельхозакадемииРоссияState scientific institution all-Russian Institute of medicinal and aromatic plants of the RAASRussian Federation2015010720151941728Copyright © Аврунин А.С., Леонтьева Н.В., Докторов А.А., 20152015Аврунин А.С., Леонтьева Н.В., Докторов А.А.Avrunin A.S., Leontyeva N.V., Doctorov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/105

ЦЕЛЬ: на основании собственных данных и анализа литературы выделить адаптационные механизмы реорганизации костных структур, которые участвуют в развитии изменений минерального и костного обмена при ХБП. Показано, что одной из причин высокой чувствительности костной ткани, в частности, и минерального обмена в целом, к регуляторно-метаболическим сдвигам, происходящим в организме при нарушении функции почек, является инкорпорация остеоцитов в лакунарно-канальцевой системе (ЛКС). Эта инкорпорация существенно ограничивает поступление к клеткам питательных веществ и удаление от них метаболитов. Поэтому в процессе филогенеза у остеоцитов сформировалась сложнейшая система адаптивной коррекции механических свойств костных структур и пропускной способности ЛКС, позволяющая проводить постоянную оптимизацию параметров окружающей среды. В результате этого остеоциты стали одним из основных регуляторов минерального метаболизма в организме. Поэтому адаптивные сдвиги функционирования клеток вызывают системные эффекты, связанные в том числе с отклонением параметров минерального гомеостаза за пределы физиологических границ. По мнению авторов, назрела клиническая необходимость разработки неинвазивного метода оценки функционального состояния остеоцитов. Предложены пути решения этой проблемы с использованием хронобиологического подхода.

THE AIM: to select adaptation mechanisms of bone structures reorganization which are involved in mineral and bone metabolism disorders in CKD following the own data and literature analysis. It is showed that one of the reasons for high sensitivity of bone tissue in particular and mineral metabolism in general to regulatory-metabolic shift in renal function disorder is the incorporation of osteocytes in lacunary-tubular system (LTS). This incorporation significantly limits cells nutrients delivery and metabolites removal. Therefore, during phylogeny in osteocytes formed a complex system of bone structures mechanical properties adaptive correction and LTS capacity which allows carrying out environmental parameters continuous optimization. As a result, osteocytes become one of the main mineral metabolism regulators of the body. Therefore, cells functioning adaptive shifts cause systemic effects associated also with mineral homeostasis parameters deviation outside the physiological limits. According to authors, it has become a clinical need to develop a non-invasive method for assessing the functional state of osteocytes. Proposed solutions to this problem using chronobiological method.

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The authors declare that there are no conflicts of interest present.