nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2009-13-1-39-50nefr-1147Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESСОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О РОЛИ ФИЗИКО-ХИМИЧЕСКИХ ФАКТОРОВ В ПАТОГЕНЕЗЕ КАЛЬЦИЕВОГО НЕФРОЛИТИАЗАTHE CURRENT VIEWS ON THE ROLE OF PHYSICO-CHEMICAL FACTORS IN PATHOGENESIS OF CALCIUM NEPHROLYTHIASISЗверевЯ. Ф.ZverevYa. Ph.

кафедра фар­макологии

656038, г.Барнаул, пр.Ленина, 40, тел.: (3852) 26-08­-35

zver@asmu.ruБрюхановВ. М.BryukhanovV. M.

кафедра фар­макологии

656038, г.Барнаул, пр.Ленина, 40, тел.: (3852) 26-08­-35

ЛампатовВ. В.LampatovV. V.

кафедра фар­макологии

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ЖариковА. Ю.JaricovA. Yu.

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656038, г.Барнаул, пр.Ленина, 40, тел.: (3852) 26-08­-35

Алтайский медицинский университет, г. БарнаулRussian Federation2009100120091313950Copyright © Зверев Я.Ф., Брюханов В.М., Лампатов В.В., Жариков А.Ю., 20092009Зверев Я.Ф., Брюханов В.М., Лампатов В.В., Жариков А.Ю.Zverev Y.P., Bryukhanov V.M., Lampatov V.V., Jaricov A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1147

В обзоре приводится анализ современных взглядов на патогенез кальциевого нефролитиаза с позиций изменений ряда физико-химических параметров, в том числе, объемов потребляемой и выделяемой жидкости, пересыщения мочи определенными солями, верхней метастабильности и др. Приводятся сведения о действии таких природных ингибиторов кристаллизации как цитрат, магний, фитат, пирофосфат, которые рассматриваются в качестве перспективных средств профилактики рецидивов мочекаменной болезни.

In the review were evaluated the modern ways on pathogenesis of calcium nephrolythiasis from the position of the various changes of physic-chemical parameters, such as amount, volume of intake and excreted fluid, the enhancement of the urine with certain salts, top metastability etc. The data on the action of such natural inhibitors of crystallization such as citrate, magnesium, phitat, pyrophosphate, which were viewed as perspective methods of prophylaxis of recurrence of urinary kidney disease were stated.

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The authors declare that there are no conflicts of interest present.