nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2009-13-4-37-50nefr-1189Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESМЕХАНИЗМ ФОРМИРОВАНИЯ КРИСТАЛЛОВ ПРИ ОКСАЛАТНОМ НЕФРОЛИТИАЗЕMECHANISM OF FORMATION OF CRYSTALS IN OXALATE NEPHROLITHIASISЖариковА. Ю.ZharikovA. Yu.

кафедра фармакологии

ЗверевЯ. Ф.ZverevYa. F.

кафедра фармакологии

656038, г. Барнаул, пр. Ленина, 40, тел. (3852) 26-08-35

zver@asmu.ruБрюхановВ. М.BrukhanovV. M.

кафедра фармакологии

ЛампатовВ. В.LampatovV. V.

кафедра фармакологии

Алтайский государственный медицинский университет, г. БарнаулRussian Federation2009100420091343750Copyright © Жариков А.Ю., Зверев Я.Ф., Брюханов В.М., Лампатов В.В., 20092009Жариков А.Ю., Зверев Я.Ф., Брюханов В.М., Лампатов В.В.Zharikov A.Y., Zverev Y.F., Brukhanov V.M., Lampatov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1189

Настоящий обзор литературы посвящен современному пониманию механизма формирования кристаллов при оксалатном нефролитиазе. Согласно современным представлениям, важнейшим звеном патогенеза оксалатного нефролитиаза является образование в интерстициальном пространстве между базальными мембранами тонкого отдела петли Генле и почечного сосочка минерал-органических отложений (бляшки Рэндалла), их открытие в мочевое пространство вследствие повреждения или гибели нефроцитов, и формирование на них под действием движущих сил кристаллизации оксалатных камней. В условиях наличия метаболических нарушений (гиперкальциурия, гиперфосфатурия, гипероксалурия) этот факт, по-видимому, приобретает ключевое значение в развитии оксалатного нефролитиаза.

This review of literature devoted to the current understanding of the mechanism of the formation of oxalate crystals in nephrolithiasis. According to current concepts, the most important link of pathogenesis of oxalate nephrolithiasis is the formation in the interstitial space between the basal membranes thin loops of Henle and the renal papilla of the mineral-organic deposits (Randall plaques), their discovery in the urinary space leads to damage or destruction nephrocyteds, and formation them the driving forces for crystallization of calcium oxalate stones. In the presence of metabolic disorders (hypercalciuria, hyperphosphaturia, hyperoxaluria), this fact seems, became crucial in the development of oxalate nephrolithiasis.

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The authors declare that there are no conflicts of interest present.