nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2010-14-1-29-49nefr-1201Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESМОДУЛЯТОРЫ ОКСАЛАТНОГО НЕФРОЛИТИАЗА. ИНГИБИТОРЫ КРИСТАЛЛИЗАЦИИMODULATORS OF OXALATE NEPHROLITHIASIS. INHIBITORS’ CRYSTALLIZATIONЗверевЯ. Ф.ZverevYa. F.

кафедра фармакологии

656038, г.Бар­наул, пр.Ленина, 40, тел. (3852) 26-08-35

zver@asmu.ruЖариковА. Ю.ZharikovA. Yu.

кафедра фармакологии

БрюхановВ. М.BrukhanovV. M.

кафедра фармакологии

ЛампатовВ. В.LampatovV. V.

кафедра фармакологии

Алтайский государственный медицинский университет, г. БарнаулRussian Federation2010100120101412949Copyright © Зверев Я.Ф., Жариков А.Ю., Брюханов В.М., Лампатов В.В., 20102010Зверев Я.Ф., Жариков А.Ю., Брюханов В.М., Лампатов В.В.Zverev Y.F., Zharikov A.Y., Brukhanov V.M., Lampatov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1201

Обзор литературы посвящен описанию факторов, препятствующих нуклеации, агрегации и росту кристаллов оксалата кальция. Основными белковыми макромолекулами, ингибирующими образование почечных камней, являются протеин Тамма-Хорсфалла, остеопонтин, бикунин и фрагмент 1 протромбина. В обзоре анализируются особенности структуры и функции данных гликопротеинов, обсуждаются их вероятные механизмы действия и роль в патогенезе мочекаменной болезни.

Review of the literature focuses on barriers to nucleation, aggregation-navigation and the growth of crystals of calcium oxalate. Main proteins, inhibiting the formation of kidney stones, are protein Tamm-Horsfalla, osteopontin, bikunin and prothrombin fragment 1. In particular, we analyze the-sti structure and function of these glycoproteins, discusses their likely mechanism of action and role in the pathogenesis of urolithiasis.

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The authors declare that there are no conflicts of interest present.