nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical Universitynefr-122Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESКлеточная физиология повреждения и восстановления почекCellular physiology of kidney injury and repairЗолотухинП. В.ZolotukhinP. V.p.zolotukhin@icloud.comБелановаА. А.BelanovaA. A.noemail@neicon.ruЛебедеваЮ. А.LebedevaU. A.noemail@neicon.ruБатюшинМ. М.BatiushinM. M.noemail@neicon.ruЧистяковВ. А.ChistyakovV. A.noemail@neicon.ruЮжный федеральный университетРоссияAcademy of biology and biotechnology, Southern federal universityRussian FederationЮжный федеральный университетРоссияRostov state medical universityRussian Federation2015010920151951722Copyright © Золотухин П.В., Беланова А.А., Лебедева Ю.А., Батюшин М.М., Чистяков В.А., 20152015Золотухин П.В., Беланова А.А., Лебедева Ю.А., Батюшин М.М., Чистяков В.А.Zolotukhin P.V., Belanova A.A., Lebedeva U.A., Batiushin M.M., Chistyakov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/122

Потеря клеточности, а также гибель клеток с высвобождением их содержимого с последующим развитием патологических иммунных реакций - центральные элементы острого повреждения почек. В настоящем обзоре рассматриваются роли отдельных видов нарушения функционирования и гибели клеток почек, механизмы регенерации поврежденной ткани на уровне клетки, а также перспективы развития терапевтических технологий, основанных на блокировке гибели клеток и активации регенерации тканей почек.

Loss of cellularity, massive cell death with its contents release and following pathologic immune response development. -acute kidney injury central elements. This review is focused on roles of systemic cell dysfunctions and cell death forms, cellular tissue repair mechanisms, as well as future development of therapeutic approaches based on cell death blocking and kidney tissue regeneration activation.

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The authors declare that there are no conflicts of interest present.