<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nefr</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology (Saint-Petersburg)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-6274</issn><issn pub-type="epub">2541-9439</issn><publisher><publisher-name>Pavlov First Saint-Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1561-6274-2010-14-3-13-16</article-id><article-id custom-type="elpub" pub-id-type="custom">nefr-1225</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕРЕДОВАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LEADING ARTICLE</subject></subj-group></article-categories><title-group><article-title>ЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ БЛОКАТОРОВ РЕЦЕПТОРОВ АНГИОТЕНЗИНА II У ДИАЛИЗНЫХ ПАЦИЕНТОВ</article-title><trans-title-group xml:lang="en"><trans-title>EFFICACY AND SAFETY OF ANGIOTENSIN II RECEPTOR BLOCKERS IN DIALYSIS PATIENTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Есаян</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Essaian</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра нефрологии и диализа</p><p>197022, Санкт-Петербург, ул. Л. Толстого, д. 17, Санкт-Петербургский государственный медицинский универ­ситет им. акад. И.П.Павлова, корп. 54; Тел.: (812)-234-91-91.</p></bio><email xlink:type="simple">esaian@spmu.rssi.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зарипова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaripova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра нефрологии и диализа</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Санкт-Петербургский государственный медицинский универ­ситет им. акад. И.П.Павлова</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>10</day><month>03</month><year>2010</year></pub-date><volume>14</volume><issue>3</issue><fpage>13</fpage><lpage>16</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Есаян А.М., Зарипова И.В., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Есаян А.М., Зарипова И.В.</copyright-holder><copyright-holder xml:lang="en">Essaian A.M., Zaripova I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephrolog.ru/jour/article/view/1225">https://journal.nephrolog.ru/jour/article/view/1225</self-uri><abstract><p>В настоящее время накопился достаточно обширный материал, основанный, в том числе, на плацебо контролируемых, многоцентровых исследованиях, который позволяет рекомендовать использование блокаторов рецепторов ангиотензина II для лечения диализных пациентов с целью нормализации АД, уменьшения ремоделирования миокарда и сосудов и, в конечном итоге, снижения смертности у данного контингента пациентов.</p></abstract><trans-abstract xml:lang="en"><p>Currently, extensive amount of material was accumulated based, includingly, on the placebo-controlled, multicenter studies, which allows us to recommend the use of angiotensin II receptor blockers for the treatment of dialysis patients in order to normalize blood pressure, myocardial and vascular remodeling and, ultimately, reduce mortality in this group of patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая болезнь почек</kwd><kwd>гемодиализ</kwd><kwd>блокаторы рецепторов ангиотензина II</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic renal disease</kwd><kwd>hemodialysis</kwd><kwd>angiotensin II receptor blockers</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Шутов АМ, Куликова ЕС, Ивашкина ТН и др. Диастолическая дисфункция и клинические проявления сердечной недостаточности у больных с додиализной хронической почечной недостаточностью. Нефрология 2001; 5 (4): 30-34</mixed-citation><mixed-citation xml:lang="en">Шутов АМ, Куликова ЕС, Ивашкина ТН и др. Диастолическая дисфункция и клинические проявления сердечной недостаточности у больных с додиализной хронической почечной недостаточностью. Нефрология 2001; 5 (4): 30-34</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Folley RN, Parfrey PS, Sarnac MJ. Epidemiology of cardiovascular diseases in chronic renal failure. J Am Soc Nephrol 1998; 9 (10): 16-23</mixed-citation><mixed-citation xml:lang="en">Folley RN, Parfrey PS, Sarnac MJ. Epidemiology of cardiovascular diseases in chronic renal failure. J Am Soc Nephrol 1998; 9 (10): 16-23</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Vakili BA, Okin PM, Devereux RB. Prognostic implications of left ventricular hypertrophy. Am Heart J2001; 141 (2): 334-341</mixed-citation><mixed-citation xml:lang="en">Vakili BA, Okin PM, Devereux RB. Prognostic implications of left ventricular hypertrophy. Am Heart J2001; 141 (2): 334-341</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Agabiti-Rosei E, Muiesan ML, Salvetti M.. Evaluation of subclinical target organ damage for risk assessment and treatment in the hypertensive patients: left ventricular hypertrophy. J Am Soc Nephrol 2006; 17 (1): 104-108</mixed-citation><mixed-citation xml:lang="en">Agabiti-Rosei E, Muiesan ML, Salvetti M.. Evaluation of subclinical target organ damage for risk assessment and treatment in the hypertensive patients: left ventricular hypertrophy. J Am Soc Nephrol 2006; 17 (1): 104-108</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">U.S. Renal Data System: USRDS 2008 annual data report. The National Institutes of Health. 2008. Am J Kidney Dis 2009; 1(Suppl 1):S1</mixed-citation><mixed-citation xml:lang="en">U.S. Renal Data System: USRDS 2008 annual data report. The National Institutes of Health. 2008. Am J Kidney Dis 2009; 1(Suppl 1):S1</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Томилина НА, Бикбов БТ. Эпидемиология хронической почечной недостаточности и новые подходы к классификации и оценке тяжести хронических прогрессирующих заболеваний почек. Тер арх 2005; 77 (6): 87-92</mixed-citation><mixed-citation xml:lang="en">Томилина НА, Бикбов БТ. Эпидемиология хронической почечной недостаточности и новые подходы к классификации и оценке тяжести хронических прогрессирующих заболеваний почек. Тер арх 2005; 77 (6): 87-92</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ringoir S. An update on uremic toxins. Kidney Int 1997; 52 (Suppl 62): 2-4</mixed-citation><mixed-citation xml:lang="en">Ringoir S. An update on uremic toxins. Kidney Int 1997; 52 (Suppl 62): 2-4</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">MаcMahon AC, Greenwald SE, Dodd SM et al. Prolonged calcium transient and myocardial remodeling in early experimental uremia. Nephr Dial Transplant 2002; 17 (5): 759-764</mixed-citation><mixed-citation xml:lang="en">MаcMahon AC, Greenwald SE, Dodd SM et al. Prolonged calcium transient and myocardial remodeling in early experimental uremia. Nephr Dial Transplant 2002; 17 (5): 759-764</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto S, Kon V. Mechanisms for increased cardiovascular disease in chronic kidney dysfunction. Current Opinion in Nephrology &amp; Hypertension 2009; 18 (3): 181-188</mixed-citation><mixed-citation xml:lang="en">Yamamoto S, Kon V. Mechanisms for increased cardiovascular disease in chronic kidney dysfunction. Current Opinion in Nephrology &amp; Hypertension 2009; 18 (3): 181-188</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Zocalli C. Cardiorenal risk as a new frontier of nephrology: research needs and areas for intervention. Nephrol Dial Transplant 2002; 17(11): 50-54</mixed-citation><mixed-citation xml:lang="en">Zocalli C. Cardiorenal risk as a new frontier of nephrology: research needs and areas for intervention. Nephrol Dial Transplant 2002; 17(11): 50-54</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Волгина ГВ. Клиническая эпидемиология кардиоваскулярных нарушений при ХПН (Обзор литературы). Нефрология и диализ 2000; 2 (1): 25-32</mixed-citation><mixed-citation xml:lang="en">Волгина ГВ. Клиническая эпидемиология кардиоваскулярных нарушений при ХПН (Обзор литературы). Нефрология и диализ 2000; 2 (1): 25-32</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Goldsmith D, MacGinley R, Smith A, Covic A. How important and how treatable is vascular stiffness as a cardiovascular risk factor in renal failure. Nephrol Dial Transplant 2002; 17 (6): 965-969</mixed-citation><mixed-citation xml:lang="en">Goldsmith D, MacGinley R, Smith A, Covic A. How important and how treatable is vascular stiffness as a cardiovascular risk factor in renal failure. Nephrol Dial Transplant 2002; 17 (6): 965-969</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">London GM, Marchais S, Guerin AP et al. Arterial structure and function in end-stage renal disease. Nephrol Dial Transplant 2002; 17 (10): 1713-1724</mixed-citation><mixed-citation xml:lang="en">London GM, Marchais S, Guerin AP et al. Arterial structure and function in end-stage renal disease. Nephrol Dial Transplant 2002; 17 (10): 1713-1724</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Schmieder R, Hilgers K, Schlaich M, Schmidt B. Renin-angiotensin system and cardiovascular risk. The Lancet 2007; 369 (9568): 1208 – 1219</mixed-citation><mixed-citation xml:lang="en">Schmieder R, Hilgers K, Schlaich M, Schmidt B. Renin-angiotensin system and cardiovascular risk. The Lancet 2007; 369 (9568): 1208 – 1219</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sica D. Angiotensin receptor blockers: new considerations in their mechanism of action. J Clin Hypertens (Greenwich)2006; 8 (5): 381–385</mixed-citation><mixed-citation xml:lang="en">Sica D. Angiotensin receptor blockers: new considerations in their mechanism of action. J Clin Hypertens (Greenwich)2006; 8 (5): 381–385</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Cuspidi C, Meani S, Valerio C et al. Effects of angiotensin II receptor blockade-based therapy with losartan on left ventricular hypertrophy and geometry in previously treated hypertensive patients. Blood Press 2006; 15(2): 107-15</mixed-citation><mixed-citation xml:lang="en">Cuspidi C, Meani S, Valerio C et al. Effects of angiotensin II receptor blockade-based therapy with losartan on left ventricular hypertrophy and geometry in previously treated hypertensive patients. Blood Press 2006; 15(2): 107-15</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlof B, Zanchetti A, Diez J, Nicholls MG et al. Effects of losartan and atenolol on left ventricular mass and neurohormonal profile in patients with essential hypertension and left ventricular hypertrophy (REGAAL Study Investigators). J Hypertens 2002; 20(9): 1855-1864</mixed-citation><mixed-citation xml:lang="en">Dahlof B, Zanchetti A, Diez J, Nicholls MG et al. Effects of losartan and atenolol on left ventricular mass and neurohormonal profile in patients with essential hypertension and left ventricular hypertrophy (REGAAL Study Investigators). J Hypertens 2002; 20(9): 1855-1864</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Cuspidi C, M. Muiesan L, Valagussa L et al. Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: the candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study. Journal of Hypertension 2002; 20 (11): 2293–2300</mixed-citation><mixed-citation xml:lang="en">Cuspidi C, M. Muiesan L, Valagussa L et al. Comparative effects of candesartan and enalapril on left ventricular hypertrophy in patients with essential hypertension: the candesartan assessment in the treatment of cardiac hypertrophy (CATCH) study. Journal of Hypertension 2002; 20 (11): 2293–2300</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Montecucco F, Pende A, Mach F. The renin-angiotensin system modulates inflammatory processes in atherosclerosis: evidence from basic research and clinical studies. Mediators Inflamm 2009; 2009: 752406</mixed-citation><mixed-citation xml:lang="en">Montecucco F, Pende A, Mach F. The renin-angiotensin system modulates inflammatory processes in atherosclerosis: evidence from basic research and clinical studies. Mediators Inflamm 2009; 2009: 752406</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Koh K, Ahn JY, Han SH et al. Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients J Am Col Cardiol 2003; 42(5): 905–910</mixed-citation><mixed-citation xml:lang="en">Koh K, Ahn JY, Han SH et al. Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients J Am Col Cardiol 2003; 42(5): 905–910</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Suzuki H, Kanno Y, Sugahara S et al. Effect of angiotensin receptor blockers on cardiovascular events in patients undergoing hemodialysis: an open-label randomized controlled trial. Am J Kidney Dis 2008; 52(3): 400-402</mixed-citation><mixed-citation xml:lang="en">Suzuki H, Kanno Y, Sugahara S et al. Effect of angiotensin receptor blockers on cardiovascular events in patients undergoing hemodialysis: an open-label randomized controlled trial. Am J Kidney Dis 2008; 52(3): 400-402</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Takahashi A, Takase H, Toriyama T et al. Candesartan, an angiotensin II type-1 receptor blocker, reduces cardiovascular events in patients on chronic haemodialysis—a randomized study. Nephrol Dial Transplant 2006; 21(9): 2507-2512</mixed-citation><mixed-citation xml:lang="en">Takahashi A, Takase H, Toriyama T et al. Candesartan, an angiotensin II type-1 receptor blocker, reduces cardiovascular events in patients on chronic haemodialysis—a randomized study. Nephrol Dial Transplant 2006; 21(9): 2507-2512</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Shibasaki Y, Masaki H, Nishiue T, Nishikawa M, Matsubara H, Iwasaka T. Angiotensin II type 1 receptor antagonist, losartan, causes regression of left ventricular hypertrophy in end-stage renal disease. Nephron 2002; 90(3): 256-261</mixed-citation><mixed-citation xml:lang="en">Shibasaki Y, Masaki H, Nishiue T, Nishikawa M, Matsubara H, Iwasaka T. Angiotensin II type 1 receptor antagonist, losartan, causes regression of left ventricular hypertrophy in end-stage renal disease. Nephron 2002; 90(3): 256-261</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kanno Y, Kaneko K, Kaneko M et al. Angiotensin receptor antagonist regresses left ventricular hypertrophy associated with diabetic nephropathy in dialysis patients. J Cardiovasc Pharmacol 2004; 43(3): 380-386</mixed-citation><mixed-citation xml:lang="en">Kanno Y, Kaneko K, Kaneko M et al. Angiotensin receptor antagonist regresses left ventricular hypertrophy associated with diabetic nephropathy in dialysis patients. J Cardiovasc Pharmacol 2004; 43(3): 380-386</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Tian Jun-Ping, Wang Tao, Wang Hong, The Prevalence of Left Ventricular Hypertrophy in Chinese Hemodialysis Patients Is Higher Than That in Peritoneal Dialysis Patients. Renal Failure 2008; 30(5): 391-400</mixed-citation><mixed-citation xml:lang="en">Tian Jun-Ping, Wang Tao, Wang Hong, The Prevalence of Left Ventricular Hypertrophy in Chinese Hemodialysis Patients Is Higher Than That in Peritoneal Dialysis Patients. Renal Failure 2008; 30(5): 391-400</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Shigenaga A, Tamura K, Dejima T et al.Effects of angiotensin II type 1 receptor blocker on blood pressure variability and cardiovascular remodeling in hypertensive patients on chronic peritoneal dialysis. Nephron Clin Pract 2009; 112(1): 31-40</mixed-citation><mixed-citation xml:lang="en">Shigenaga A, Tamura K, Dejima T et al.Effects of angiotensin II type 1 receptor blocker on blood pressure variability and cardiovascular remodeling in hypertensive patients on chronic peritoneal dialysis. Nephron Clin Pract 2009; 112(1): 31-40</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Suzuki H, Nakamoto H, Okada H et al. A Selective Angiotensin receptor antagonist, valsartan, produced regression of left ventricular hypertrophy associated with a reduction of arterial stiffness. Advances in Peritoneal Dialysis 2003; 19(1): 50-66</mixed-citation><mixed-citation xml:lang="en">Suzuki H, Nakamoto H, Okada H et al. A Selective Angiotensin receptor antagonist, valsartan, produced regression of left ventricular hypertrophy associated with a reduction of arterial stiffness. Advances in Peritoneal Dialysis 2003; 19(1): 50-66</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Wen-Hung Huang, Ching-Wei Hsu, Yung-Chang Chen. Angiotensin II Receptor Antagonists Supplementation is Associated with Arterial Stiffness: Insight from a Retrospective Study in 116 Peritoneal Dialysis Patients. Renal Failure 2007; 29(7): 843-848</mixed-citation><mixed-citation xml:lang="en">Wen-Hung Huang, Ching-Wei Hsu, Yung-Chang Chen. Angiotensin II Receptor Antagonists Supplementation is Associated with Arterial Stiffness: Insight from a Retrospective Study in 116 Peritoneal Dialysis Patients. Renal Failure 2007; 29(7): 843-848</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Suzuki H, Kanno Y, Kaneko K. Comparison of the effects of angiotensin receptor antagonist, angiotensin converting enzyme inhibitor, and their combination on regression of left ventricular hypertrophy of diabetes type 2 patients on recent onset hemodialysis therapy. Ther Apher Dial 2004; 8(4): 320-327.</mixed-citation><mixed-citation xml:lang="en">Suzuki H, Kanno Y, Kaneko K. Comparison of the effects of angiotensin receptor antagonist, angiotensin converting enzyme inhibitor, and their combination on regression of left ventricular hypertrophy of diabetes type 2 patients on recent onset hemodialysis therapy. Ther Apher Dial 2004; 8(4): 320-327.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Fujii H, Nakahama H, Yoshihara F, et al. Life-threatening hyperkalemia during a combined therapy with the angiotensin receptor blocker candesartan and spironolactone. Kobe J Med Sci 2005; 51(1): 1-6</mixed-citation><mixed-citation xml:lang="en">Fujii H, Nakahama H, Yoshihara F, et al. Life-threatening hyperkalemia during a combined therapy with the angiotensin receptor blocker candesartan and spironolactone. Kobe J Med Sci 2005; 51(1): 1-6</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Карабаева АЖ. Альдостерон как фактор прогрессирования кардиоваскулярных осложнений при хронической болезни почек. Автореф. дис. д-ра. мед. наук. СПб., 2009</mixed-citation><mixed-citation xml:lang="en">Карабаева АЖ. Альдостерон как фактор прогрессирования кардиоваскулярных осложнений при хронической болезни почек. Автореф. дис. д-ра. мед. наук. СПб., 2009</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">W Fang, Oreopoulos D, Bargman J. Use of ACE inhibitors or angiotensin receptor blockers and survival in patients on peritoneal dialysis. Nephrology Dial Transplant 2008; 23(11): 3704-3710</mixed-citation><mixed-citation xml:lang="en">W Fang, Oreopoulos D, Bargman J. Use of ACE inhibitors or angiotensin receptor blockers and survival in patients on peritoneal dialysis. Nephrology Dial Transplant 2008; 23(11): 3704-3710</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Sica D. Renal handling of angiotensin receptor blockers: Clinical relevance. Current Hypertension Reports 2003; 5(4): 337-339</mixed-citation><mixed-citation xml:lang="en">Sica D. Renal handling of angiotensin receptor blockers: Clinical relevance. Current Hypertension Reports 2003; 5(4): 337-339</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Gradman A, Michelson E. Comparative effects of candesartan cllexetil and losartan in systemic hypertension. AJH-APRIL 1999; 12(4 part 2): 121A</mixed-citation><mixed-citation xml:lang="en">Gradman A, Michelson E. Comparative effects of candesartan cllexetil and losartan in systemic hypertension. AJH-APRIL 1999; 12(4 part 2): 121A</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
