nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2010-14-3-17-31nefr-1226Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРОЛЬ ПОЧКИ В РЕГУЛЯЦИИ СУТОЧНЫХ РИТМОВ ОРГАНИЗМАTHE KIDNEY ROLE IN REGULATION OF CIRCADE RITHMS OF THE ORGANISMБрюхановВ. М.BryukhanovV. M.

кафедра фармакологии

656038, г. Барнаул, пр. Ленина, д.40; Алтайский медицинский университет, кафедра фармакологии. Тел.: (3852) 36-61-13.

zver@asmu.ruЗвереваА. Я.ZverevaA. J.

кафедра фармакологии

Алтайский государственный медицинский университет, г. БарнаулRussian Federation2010100320101431731Copyright © Брюханов В.М., Зверева А.Я., 20102010Брюханов В.М., Зверева А.Я.Bryukhanov V.M., Zvereva A.J.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1226

Обзор литературы касается организации циркадианных ритмов организма и места почки в их регуляции. Приводится описание центрального пейсмекера (супрахиазматические ядра гипоталамуса) и его взаимодействия с периферическими осцилляторами, в том числе – с почкой. Рассматриваются суточные флюктуации экскреторной функции почек, скорости клубочковой фильтрации и канальцевой реабсорбции. Обсуждаются современные взгляды на обеспечение циркадианных ритмов почечной функции в контексте последних достижений молекулярной биологии и генетики.

Review of the literature concerns the organization of circadian rhythms and the place of kidney in their regulation. The description of the central pacemaker (the suprachiasmatic nucleus of the hypothalamus) and its interaction with the peripheral oscillators, including – the kidney is discussed. The daily fluctuations of excretory kidney function, the velocity of glomerular filtrationand tubular reabsorption are viewed. The modern views on the provision of circadian rhythms of renal function in the context of recent achievements in molecular biology and genetics are discussed.

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The authors declare that there are no conflicts of interest present.