nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2018-22-6-23-29nefr-1624Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESСОВРЕМЕННЫЙ ВЗГЛЯД НА ПАТОГЕНЕЗ СИНДРОМА ИШЕМИИ–РЕПЕРФУЗИИ ПРИ ТРАНСПЛАНТАЦИИ ПОЧКИTHE MODERN VIEW ON THE PATHOGENESIS OF THE ISCHEMIA–REPERFUSION SYNDROME IN KIDNEY TRANSPLANTATIONАртемовД. В.ArtemovD. V.

129110, Россия, Москва, ул. Щепкина, д. 61/2, корп. 1.

Артемов Дмитрий Владимирович, консультативно-диагностический центр, терапевтическое отделение.

Тел.: (915) 110-16-15.

129110, Russia, Moscow, Shchepkina st., 61/2, build 1.

Dmitry V. Artemov, Advisory-diagnostic center, Department of therapy.

Phone: (915) 110-16-15.

anatom555@yandex.ruЗулькарнаевА. Б.ZulkarnaevA. B.

129110, Россия, Москва, ул. Щепкина, д. 61/2, корп. 6.

Зулькарнаев Алексей Батыргараевич, д-р мед. наук, кафедра трансплантологии, нефрологии и искусственных органов.

Тел.: (916) 705-98-99.

129110, Russia, Moscow, Shchepkina st., 61/2, build 6.

Alexey B. Zulkarnaev, MD, PhD, DMedSci, Department of Transplantology, Nephrology and artifi cial organs.

Phone: (916) 7059899.

7059899@gmail.comМосковский областной научно-исследовательский клинический институт им. М.Ф. Владимирского.РоссияM.F. Vladimirsky Moscow Regional Research Clinical Institute.Russian Federation2018231220182262329Copyright © Артемов Д.В., Зулькарнаев А.Б., 20182018Артемов Д.В., Зулькарнаев А.Б.Artemov D.V., Zulkarnaev A.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1624

В обзоре освещены основные факторы патогенеза синдрома ишемии/реперфузии (ИРС) трансплантата почки (ТП). Описаны клеточные, гуморальные, а также неспецифические механизмы развития почечного повреждения. Возможности эффективного воздействия на него ограничены объективными трудностями, которые связаны, главным образом, с наличием множества альтернативный путей, которые, в конечном счете, приводят к тяжелому повреждению ТП, быстрому развитию хронической трансплантационной нефропатии и повышают риск утраты ТП. Необходимы дальнейшие исследования способов целенаправленного воздействия на основные звенья патогенеза ИРС.

This article highlights the main factors of the pathogenesis of ischemia/reperfusion syndrome of renal allograft. Cellular, humoral, and nonspecific mechanisms of renal damage development are described. The possibilities of effective influence on it are limited by objective difficulties, which are mainly associated with the presence of a variety of alternative ways, which ultimately lead to severe graft damage, the rapid development of chronic transplant nephropathy and increase the risk of graft loss. Further research is needed to develop ways to target the main links of pathogenesis.

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The authors declare that there are no conflicts of interest present.