nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2018-23-1-18-31nefr-1661Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESМИКРОБИОТА КИШЕЧНИКА И ХРОНИЧЕСКАЯ БОЛЕЗНЬ ПОЧЕК. СООБЩЕНИЕ ВТОРОЕCOLONIC MICROBIOTA AND CHRONIC KIDNEY DISEASES INTESTINAL MICROBIOTA AND CHRONIC KIDNEY DISEASE. PART IIЛукичевБ. Г.LukichevB. G.

Проф. Лукичев Борис Георгиевич, д-р мед. наук

197022, Санкт-Петербург, ул. Л. Толстого, д. 17. Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, кафедра пропедевтики внутренних болезней. Тел.: (812)-234-01-65

Prof. Boris G. Lukichev MD, PhD, DMedSci 

197022, St-Petersburg, L. Tolstoy st., 17, build. 54, First Pavlov St-Petersburg State Medical University, Department of propedeutics of internal diseases.

Phone: (812)-234-01-65

РумянцевA. Ш.RumyantsevA. Sh.

Проф. Румянцев Александр Шаликович, д-р мед. наук

199106, Санкт-Петербург, 21-я линия В.О., д. 8а. Санкт-Петербургский государственный университет, кафедра факультетской терапии. Тел.: +7 (812) 326-03-26 

Prof. Alexandr Sh.Rumyantsev MD, PhD, DMedSci

199106 Russia, Saint Petersburg, V.O., 21 line 8a. Saint Petersburg State University Department of Faculty Therapy

Phone: +7(812) 326-03-26

rash.56@mail.ruПанинаИ. Ю.PaninaI. Yu.

Проф. Панина Ирина Юревна, д-р мед наук

197022, Санкт-Петербург, ул. Л. Толстого, д. 17. Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова, кафедра пропедевтики внутренних болезней. Тел.: (812)-234-01-65

Prof. Irina Yu. Panina MD, PhD, DMedSci

197022, Russia, St-Petersburg, L. Tolstoy st., 17, build. 54, First Pavlov St-Petersburg State Medical University, Department of propedeutics of internal diseases.

Phone: (812)-234-01-65

АкименкоВ.AkimenkoV.

Akimenko V.

197022, Russia, St-Petersburg, L. Tolstoy st., 17, build. 54, First Pavlov St-Petersburg State Medical University, Department of propedeutics of internal diseases.

Phone: (812)-234-01-65

Кафедра пропедевтики внутренних болезней Первого Санкт-Петербургского государственного медицинского университетаРоссияDepartment of propedeutics of internal diseases of First Pavlov St-Petersburg State Medical UniversityRussian FederationКафедра пропедевтики внутренних болезней Первого Санкт-Петербургского государственного медицинского университета; кафедра факультетской терапии Санкт-Петербургского государственного университетаРоссияDepartment of propedeutics of internal diseases of First Pavlov St-Petersburg State Medical University; Department of Faculty Therapy of Saint Petersburg State UniversityRussian Federation2019060220192311831Copyright © Лукичев Б.Г., Румянцев A.Ш., Панина И.Ю., Акименко В., 20192019Лукичев Б.Г., Румянцев A.Ш., Панина И.Ю., Акименко В.Lukichev B.G., Rumyantsev A.S., Panina I.Y., Akimenko V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1661

Интерес к изучению роли желудочно-кишечного тракта в поддержании гомеостаза при хронической болезни почек является традиционным. Он послужил, в частности, отправной точкой для создания энтеросорбентов. Однако, если ранее основное внимание было обращено на механическое удаление ряда потенциально опасных биологически активных веществ, то в последнее время предметом интереса стала кишечная микробиота. Возрос интерес к коррекции дисбиоза с целью снижения уровня уремических токсинов, активности окислительного и воспалительного стресса. Вторая часть обзора литературы на эту тему посвящена вопросам применения пребиотиков, пробиотиков и синбиотиков.Подробно изложены современные трактовки терминов. Дана классификация средств, используемых при хронической болезни почек. Представлены потенциальные механизмы их действия. Обсуждены позитивные и негативные результаты экспериментальных и клинических исследований.

Interest in studying the role of the gastrointestinal tract in maintaining homeostasis in chronic kidney disease is a traditional one. It served, in particular, as a starting point for the creation of enterosorbents. However, if earlier the main attention was paid to the mechanical removal of a number of potentially dangerous biologically active substances, recently an intestinal microbiota has become an object of interest. The first part of the review of the literature on this topic is devoted to questions of terminology, the normal physiology of the colon microbiota. A detailed description of dysbiosis is given. The features of the main groups of microorganisms are reflected. The hypothetical and confirmed interrelations of the intestine-kidney axis are presented. The pathogenetic mechanisms of the influence of colon dysbiosis on the processes of local and systemic inflammation are discussed. The influence of dysbiosis on the state of the kidney parenchyma and its participation in the progression of CKD are debated.

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The authors declare that there are no conflicts of interest present.