nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2019-23-3-21-28nefr-1690Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESК вопросу о дефиците витамина D при хронической болезни почек. Литературный обзорAbout the question of vitamin D deficiency in chronic kidney disease. Literature reviewhttps://orcid.org/0000-0002-3717-7091АграновичН. В.AgranovichN. V.

Агранович Надежда Владимировна - доктор медицинских наук, профессор кафедра поликлинической терапии, заведующая кафедрой.

355017, Ставрополь, ул. Мира, д. 310, Тел.: 8-962-443-04-50

Nadezhda V. Agranovich - MD, PhD, DMedSci, Prof.Department of Polyclinic Therapy, chief.

355017, Stavropol, str. Mira, 310, Phone: 8(962) 443-04-50

nagranovich@mail.ruhttps://orcid.org/0000-0002-6517-7427ПилиповичЛ. А.PilipovichL. A.

Пилипович Людмила Алексеевна - кафедра поликлинической терапии, ассистент.

355017, Ставрополь, ул. Мира, д. 310, Тел.: 8 903-446-69-88

Lyudmila A. Pilipovich – MD,Department of Polyclinic Therapy, assistant.

355017, Stavropol, str. Mira, 310, Phone: 8 903-446-69-88

rakitina.l@list.ruhttps://orcid.org/0000-0003-1121-6774АлботоваЛ. В.AlbotovaL. V.

Алботова Лаура Владимировна - кафедра поликлинической терапии, аспирант.

355017, Ставрополь, ул. Мира, д. 310, тел.: 8 928-365-55-56

Lyudmila A. Pilipovich – MD, Department of Polyclinic Therapy, assistant.

355017, Stavropol, str. Mira, 310, Stavropol State Medical University, Phone: 8 903-446-69-88

laurka-2015@mail.ruКлассоваА. Т.KlassovaA. T.

Классова Айгуль Тахировна - кафедра поликлинической терапии, ассистент.

355017, Ставрополь, ул. Мира, д. 310, тел.: 8-919-752-46-52

Aigul T. Klassova - MD,Department of Polyclinic Therapy, assistant.

355017, Stavropol, str. Mira, 310, Phone: 8-919-752-46-52

aigul.pirmuhametova@yandex.ruСтавропольский государственный медицинский университетРоссияStavropol State Medical UniversityRussian Federation2019220320192332128Copyright © Агранович Н.В., Пилипович Л.А., Алботова Л.В., Классова А.Т., 20192019Агранович Н.В., Пилипович Л.А., Алботова Л.В., Классова А.Т.Agranovich N.V., Pilipovich L.A., Albotova L.V., Klassova A.T.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1690

Дефицит витамина D относится к числу состояний, которые в настоящее время вызывают повышенный интерес в связи с широкой распространённостью практически во всех регионах мира и характеризуются крайне неблагоприятными последствиями для здоровья и качества жизни пациентов. Проведенные в последние годы масштабные исследования продемонстрировали высокую распространенность дефицита витамина D в различных возрастных группах, при различных заболеваниях и в различных географических регионах. Активное изучение внекостных (некальциемических) эффектов витамина D позволило оценить его разнообразные эффекты, включая иммунотропные, влияние на сердечную и скелетную мускулатуру, прямое действие на β-клетки островков Лангерганса поджелудочной железы, адипоциты, синтез гормонов и ряда биологически активных веществ. В настоящее время накоплено достаточно сведений о влиянии витамина D на темпы прогрессирования хронической болезни почек (ХБП). У пациентов с ХБП снижение продукции кальцитриола в проксимальных канальцах почек ассоциируется с риском развития нефросклероза и артериальной гипертензии. Своевременное выявление недостаточности витамина D затруднено из-за разнообразия клинических проявлений, стёртого, малосимптомного и нередко атипичного течения при различных заболеваниях. Скрининг дефицита витамина D в группах генетического риска признан одним из способов первичной профилактики многих хронических неинфекционных заболеваний, в том числе аутоиммунных, почечных и онкологических.

Vitamin D deficiency is among the conditions that are currently causing increased interest due to the high prevalence in almost all regions of the world and are characterized by extremely adverse consequences for the health and quality of life of patients. Large-scale studies conducted in recent years have demonstrated a high prevalence of vitamin D deficiency in various age groups, various diseases and various geographical regions. The active study of extraossaos (non-calcemic) effects of vitamin D made it possible to evaluate its diverse effects, including immunotropic, effects on the heart and skeletal muscles, the direct effect on the β-cells of the pancreatic islets of Langerhans, adipocytes, the synthesis of hormones and a number of biologically active substances. Currently, enough information has been accumulated on the effect of vitamin D on the progression of chronic kidney disease (CKD). In patients with CKD, decreased calcitriol production in the proximal tubule of the kidney is associated with the risk of nephrosclerosis and arterial hypertension. The timely detection of vitamin D deficiency is difficult due to the diversity of clinical manifestations, erased, low-symptom, and often atypical course in various diseases. Screening for vitamin D deficiency in genetic risk groups is recognized as one of the primary prevention methods for many chronic noncommunicable diseases, including autoimmune, renal, and oncological diseases.

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The authors declare that there are no conflicts of interest present.