nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2019-23-4-36-46nefr-1719Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESХронический гепатит С: современное состояние проблемыChronic hepatitis C: modern condition of the problemhttps://orcid.org/0000-0003-3643-7354ЛиозновД. А.LioznovD. A.

Лиознов Дмитрий Анатольевич - доктор медицинских наук, заведующий кафедрой инфекционных болезней и эпидемиологии, доктор медицинских наук, доцент ПСПбГМУ им. акад. И.П. Павлова; заместитель директора по научной работе НИИ гриппа им. А.А. Смородинцева.

197022, Санкт-Петербург, ул. Л. Толстого, д. 6/8, Тел.: (812) 338-60-40; 197376, Санкт-Петербург, улица профессор Попова, д. 15/17

Dmitry A. Lioznov -  MD, PhD, DMedSci, Assistant professor First Pavlov SMU, Head of Department of Infectious Diseases and Epidemiology, Deputy Director for R Smorodintsev RII.

dlioznov@yandex.ruhttps://orcid.org/0000-0002-9504-0827ДунаеваН. В.DunaevaN. V.

Дунаева Наталья Викторовна - кандидат медицинских наук, доцент, заведующая отделением соматической патологии.

190103, Санкт-Петербург, наб. Обводного канала, д. 179. Тел.: +7-921-741-88-20

Natalia V. Dunaeva - MD, PhD, assistant professor Head of the outpatient medical Department.

190103, 179 nab. Obvodny kannal, St.Petersburg, Phone: +7(921) 741-88-20

nvch@mail.ruЧунгН. Х.ChungN. H.

Чунг Нгуен Хыу - ассистент кафедры внутренних болезней, заочный аспирант Научно-исследовательского института эпидемиологии и микробиологии им. Пастера.

Хошимин, ул. Хонг Банг, д. 217, Тел.: (+84) 37-67-68-616

Nguyen Huu Chung – MD,assistant of Department of Internal Medicine, extramural PhD student of the Research Institute of Epidemiology and Microbiology named after Pasteur.

Ho Chi Minh city, №217 Hong Bang st., Phone: (+84) 37-67-68-616

chung43@mail.ruhttps://orcid.org/0000-0001-5458-4329ГорчаковаО. В.GorchakovaO. V.

Горчакова Ольга Владимировна - кандидат медицинских наук, научный сотрудник лаборатории хронических вирусных инфекций НИЦ, ассистент кафедры инфекционных болезней и эпидемиологии.

197022, Санкт-Петербург, ул. Л. Толстого, д. 6/8, Тел.: +7(812)338-70-58

Olga V. Gorchakova - MD, PhD, researcher at the laboratory of chronic viral infections SIC, assistant of the Department of infectious diseases and epidemiology.

197022, St. Petersburg, ul. L. Tolstoy 6/8,Phone +7(812)338-70-58

gorchakova-spmu@yandex.ruhttps://orcid.org/0000-0002-1784-6235АнтоноваТ. В.AntonovaT. V.

Антонова Тамара Васильевна - доктор медицинских наук, профессор, кафедра инфекционных болезней и эпидемиологии.

197022, Санкт-Петербург, ул. Л. Толстого, д. 6/8, Тел.: +7(812)338-70-58

Antonova Tamara Vasilyevna - MD, PhD, DMedSci, Prof, Department of infectious diseases and epidemiology.

197022, St. Petersburg, L. Tolstoy str. 6/8, Phone +7(812)338-70-58

antonovatv28@yandex.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова; Научно-исследовательский институт гриппа им. А.А. СмородинцеваРоссияPavlov First Saint Petersburg State Medical University; Influenza Research Institute A.A. SmorodintsevaRussian FederationЦентр по профилактике и борьбе со СПИД и инфекционными заболеваниямиРоссияUnit of Somatic Pathology, Center for the Prevention and Control of AIDS and Infectious DiseasesRussian FederationМедицинский и фармацевтический университетРоссияUniversity of Medical and PharmaceuticalRussian FederationПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаРоссияPavlov First Saint Petersburg State Medical UniversityRussian Federation2019220620192343646Copyright © Лиознов Д.А., Дунаева Н.В., Чунг Н.Х., Горчакова О.В., Антонова Т.В., 20192019Лиознов Д.А., Дунаева Н.В., Чунг Н.Х., Горчакова О.В., Антонова Т.В.Lioznov D.A., Dunaeva N.V., Chung N.H., Gorchakova O.V., Antonova T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1719

Хронический гепатит С (ХГС) является одной из распространенных хронических вирусных инфекций. Современные достижения в терапии ХГС позволили ВОЗ разработать Глобальную стратегию сектора здравоохранения по вирусному гепатиту на 2016-2021 гг с целью его элиминации к 2030 г. Противовирусные препараты новых поколений обладают терапевтической эффективностью более 98% и широкими показаниями для применения. В то же время, имеются особые группы пациентов, у которых ограничен выбор схемы противовирусной терапии и отличается ее эффективность от общей популяции больных ХГС. В обзорной статье приводятся данные об эпидемиологии, патогенезе, клинических проявлениях ХГС и современных подходах к терапии заболевания. Особое внимание уделено больным с внепеченочными проявлениям хронической ВГС-инфекции.

Chronic hepatitis C (CHC) is one of the common chronic viral infections. Current advances in the treatment of chronic hepatitis C have allowed WHO to develop a Global health sector strategy on viral hepatitis for 2016-2021 with the purpose of its elimination by 2030. Antiviral drugs of new generations have therapeutic efficacy of more than 98% and wide indications for use. At the same time, there are special groups of patients in whom the choice of antiviral therapy regimen is limited and its effectiveness differs from the general population of patients with chronic hepatitis C. This review provides data on the epidemiology, pathogenesis, clinical manifestations of CHC, and current approaches to the treatment of the disease. Particular attention is paid to patients with extrahepatic manifestations of chronic HCV infection.

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The authors declare that there are no conflicts of interest present.