nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2019-23-4-112-118nefr-1729Research ArticleПРОГРАММА НЕПРЕРЫВНОГО ПОСЛЕДИПЛОМНОГО ОБРАЗОВАНИЯ ПО НЕФРОЛОГИИPROGRAM ON CONTINUOUS POSTGRADUATE EDUCATION ON NEPHROLOGYСовременные биомаркеры повреждения почек в педиатрииModern biomarkers of renal damage in pediatricshttps://orcid.org/0000-0002-0581-7285СмирноваН. Н.SmirnowaN. N.

Смирнова Наталия Николаевна - докор медицинских наук, профессор, кафедра педиатрии, заведующая кафедрой.

197022, Санкт-Петербург, ул. Л. Толстого, д. 6-8, Тел.: +7(921)429-49-31

Natalia Smirnowa - PhD, DMedSci, Prof., Nephrology Laboratory of the head of pediatric department.

197022, St-Petersburg , L.Tolstoy st., 17, build. 54

nephro-uro-kids@mail.ruГалкинаО. В.GalkinaO. V.

Галкина Ольга Владимировна - кандидат биологических наук, лаборатория биохимического гомеостаза, заведующая лабораторией.

197022, Санкт-Петербург, ул. Л. Толстого, д. 6-8, Тел.: +7 (812) 338-69-31

Olga Galkina - PhD, Nephrology Laboratory of Biochemical Homeostasis, head.

197022, St-Petersburg , L.Tolstoy st., 17, build. 54, 7(812)338-69-31

ovgalkina@mail.ruhttps://orcid.org/0000-0002-0992-1709НовиковаВ. П.NovikovaV. P.

Новикова Валерия Павловна - докор медицинских наук, профессор, кафедры детских болезней педиатрического факультета ПСПбГМУ им. акад. И.П. Павлова, лаборатория медико-социальных проблем в педиатрии, заведующая лабораторией СПбГПМУ.

197022, Санкт-Петербург, ул. Л. Толстого, д. 6-8; Санкт-Петербург, ул. Литовская, д. 2, Тел. +7(911)738-63-50

Valeria Novikova - MD, PhD, DMedSci, Prof. children diseases department First Pavlov St.-Petersburg SMU; laboratory of medical and social problems in pediatrics the head SPSPMU.

197022, St-Petersburg , L.Tolstoy st., 6-8; Saint Petersburg, Litovskaja str.,2, Phone +7(911)738-63-50

novikova-vp@mail.ruhttps://orcid.org/0000-0001-5412-1412ПрокопьеваН. Э.ProkopyevaN. E.

Прокопьева Наталья Эдуардовна - лаборатория медико-социальных проблем в педиатрии, врач-исследователь.

194100, Санкт-Петербург, ул. Литовская, д. 2

Natalja Prokopjeva - MD. laboratory of medical and social problems in pediatrics, physician-researcher of.

194100, Saint Petersburg Litovskaja str., 2

Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П.ПавловаРоссияFirst Pavlov Saint-Petersburg State Medical UniversityRussian FederationПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова; Санкт-Петербургский государственный педиатрический медицинский университетРоссияFirst Pavlov Saint-Petersburg State Medical University; Saint-Petersburg State Pediatric Medical UniversityRussian FederationСанкт-Петербургский государственный педиатрический медицинский университетРоссияSaint-Petersburg State Pediatric Medical UniversityRussian Federation201923062019234112118Copyright © Смирнова Н.Н., Галкина О.В., Новикова В.П., Прокопьева Н.Э., 20192019Смирнова Н.Н., Галкина О.В., Новикова В.П., Прокопьева Н.Э.Smirnowa N.N., Galkina O.V., Novikova V.P., Prokopyeva N.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1729

Острое повреждение почек (ОПП) в отличие от острой почечной недостаточности является более широким понятием. Даже незначительные изменения экскреторной функции почек оказывают существенное влияние на работу всего организма. Возникновение ОПП увеличивает риск летального исхода, сроки госпитализации и стоимость лечения любой патологии. Цель данного обзора литературы - проанализировать возможности использования ряда маркеров в ранней диагностике различных вариантов ОПП в педиатрии. В обзор включены наиболее изученные и применимые в педиатрической практике маркеры: интерлейкин-18, липокалин, ассоциированный с желатиназой нейтрофилов (NGAL), молекула повреждения почек-1 (kim-1), цистатин С.

Acute kidney injury (AKI), in contrast to acute renal failure, is a broader concept. Even minor changes in the excretory function of the kidneys have a significant impact on the work of the whole organism. The occurrence of AKI increases the risk of death, the length of hospitalization and the cost of treating any pathology. The purpose of this literature review is to analyze the possibilities of using a number of markers in the early diagnosis of various types of AKI in pediatrics. The review includes the most studied and applicable markers in pediatric practice - interleukin-18, Neutrophil Gelatinase-Associated Lipocalin (NGAL), kidney damage molecule-1 (KIM-1), cystatin C.

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The authors declare that there are no conflicts of interest present.