nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.36485/1561-6274-2020-24-1-22-38nefr-1787Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESУромодулин и почкиUromodulin and kidneysХасунМ.KhasunM.

Мохамад Хасун, кандидат медицинских наук, кафедра пропедевтики внутренних болезней с клиникой, ассистент кафедры.

Khasun Mohamad, MD, PhD, Department of Propedeutics of Internal Diseases, Assistant. 

197022, Pavlov University, L'va Tolstogo str. 17, build 54, Saint Petersburg, Russian Federation

nefrolog2013@mail.ruhttps://orcid.org/0000-0003-0515-2575ОрловаС. А.OrlovaS. A.

Доцент Орлова Светлана Александровна, кандидат медицинских наук, кафедра пропедевтики внутренних болезней с клиникой, доцент кафедры 

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54

Svetlana A. Orlova, MD, PhD. Department of Propedeutics of Internal Diseases, Assistant prof. 

197022, Pavlov University, L'va Tolstogo str. 17, build 54, Saint Petersburg, Russian Federation

 

orlova_s_2001@mail.ruhttps://orcid.org/0000-0003-0793-5629КаюковИ. Г.KayukovI. G.

Профессор Каюков Иван Глебович, доктор медицинских наук, научно-исследовательский институт нефрологии, кафедра нефрологии и диализа 

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54

Prof. Ivan G. Kayukov, MD, PhD, DMedSci, Research Institute of Nephrology; Department of Nephrology and Dialysis

197022, Pavlov University, L'va Tolstogo str. 17, build 54, Saint Petersburg, Russian Federation

kvaka55@mail.ruhttps://orcid.org/0000-0001-7265-7392ГалкинаО. В.GalkinaO. V.

Галкина Ольга Владимировна, кандиддат биологических наук, Научно-исследовательский институт нефрологии, заведующая лабораторией биохимического гомеостаза 

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54

Olga V. Galkina, PhD, Research Institute of Nephrology, Laboratory of Biochemical Homeostasis, Head.

197022, Pavlov University, L'va Tolstogo str. 17, build 54, Saint Petersburg, Russian Federation

ovgalkina@mail.ruhttps://orcid.org/0000-0002-7532-2405БересневаО. Н.BeresnevaO. N.

Береснева Ольга Николаевна, кандиддат биологических наук, Научно-исследовательский институт нефрологии, лаборатория клинической физиологии почек, старший научный сотрудник 

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54

Olga N. Beresneva, PhD, senior researcher, Research Institute of Nephrology, Laboratory of Clinical Physiology of the Kidney

197022, Pavlov University, L'va Tolstogo str. 17, build 54, Saint Petersburg, Russian Federation

beresnevaolga@list.ruПарастаеваМ. М.ParastaevaM. M.

Парастаева Марина Магрезовна, кандиддат биологических наук, Научно-исследовательский институт нефрологии, лаборатория клинической физиологии почек, старший научный сотрудник 

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54

Marina M. Parastaeva, PhD, senior researcher, Research Institute of Nephrology, Laboratory of Clinical Physiology of the Kidney

197022, Pavlov University, L'va Tolstogo str. 17, build 54, Saint Petersburg, Russian Federation

parastaeva@list.ruКучерА. Г.KucherA. G.

Профессор Кучер Анатолий Григорьевич, доктор медицинских наук, кафедра пропедевтики внутренних болезней с клиникой

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54

Prof. Anatoly G. Kucher, MD, PhD, DMedSci, Department of Propedeutics of Internal Diseases

197022, Pavlov University, L'va Tolstogo str. 17, build 54, Saint Petersburg, Russian Federation

prof.kucher@yandex.ruhttps://orcid.org/0000-0001-7300-211XМосинаН. В.MosinaN. V.

Мосина Нина Валерьевна, кандидат медицинских наук, научно-исследовательский институт нефрологии, руководитель отделения клинических исследований

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54

Nina V. Mosina, MD, PhD, Research Institute of Nephrology, Department of clinical trials, Head.

197022, Pavlov University, L'va Tolstogo str. 17, build 54, Saint Petersburg, Russian Federation

ninamosina@mail.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаРоссияPavlov UniversityRussian Federation2020230120202412238Copyright © Хасун М., Орлова С.А., Каюков И.Г., Галкина О.В., Береснева О.Н., Парастаева М.М., Кучер А.Г., Мосина Н.В., 20202020Хасун М., Орлова С.А., Каюков И.Г., Галкина О.В., Береснева О.Н., Парастаева М.М., Кучер А.Г., Мосина Н.В.Khasun M., Orlova S.A., Kayukov I.G., Galkina O.V., Beresneva O.N., Parastaeva M.M., Kucher A.G., Mosina N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1787

Уромодулин (УМО) – многофункциональный гликопротеин, экспрессирующийся в эпителиальных клетках толстого восходящего отдела петли Генле. В настоящее время накоплено достаточно сведений о механизмах биосинтеза, апикального и базолатерального транспорта УМО, изменениях концентрации в моче и крови при повреждении различных компартментов почки, роли УМО в защите почек от инфекций, поддержании минерального гомеостаза, развитии артериальной гипертензии и участии этого гликопротеина в других физиологических и патологических процессах. В статье обсуждается клиническое значение УМО в развитии и прогрессировании хронической болезни почек (ХБП), прогностическое значение оценки концентрации УМО в моче и крови в плане риска сердечно-сосудистых заболеваний и вероятности развития острого повреждения почек у больных с сердечно-сосудистой патологией. Кратко освещаются вопросы мутации гена УМО и развития аутосомно-доминантной тубулоинтерстициальной болезни почек.

Uromodulin (UMO) is a multifunctional glycoprotein expressed in the epithelial cells of the thick ascending part of the loop of Henle. Currently a lot of data about mechanisms of biosynthesis, apical and basolateral transport of UMO, changes in urine and blood concentrations in different kidney compartments damage, roles of UMO in protecting kidneys from infections, maintaining mineral homeostasis, development of arterial hypertension and the participation of this glycoprotein in other physiological and pathological processes has been accumulated. The article discusses the clinical significance of UMO in the development and progression of chronic kidney disease, prognostic value of UMO urine and blood concentrations in terms of the risk of cardiovascular diseases and probability of acute kidney damage in patients with cardiovascular pathology. Briefly highlights issues of UMO gene mutation and development of autosomal dominant tubulointerstitial kidney disease.

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The authors declare that there are no conflicts of interest present.