nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.36485/1561-6274-2020-24-4-21-36nefr-1855Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESКреатинин в современной оценке функционального состояния почек (обзор литературы и собственные данные)Creatinin in the modern evaluation of the kidneys functional condition (literature review and own data)https://orcid.org/0000-0003-0793-5629КаюковИ. Г.KayukovI. G.

Проф. Каюков Иван Глебович, д-р мед. наук197022, Санкт-Петербург, ул. Л. Толстого, д. 17. 

Тел.: 8(981)8153949

Prof. Ivan G. Kayukov, MD, PhD, DMedSci

197022, Leo Tolstoy st. 17, build 54

Phone: 8(981)8153949

kvaka55@mail.ruhttps://orcid.org/0000-0001-7265-7392ГалкинаО. В.GalkinaO. V.

Галкина Ольга Владимировна, канд. биол. наук, лаборатория биохимического гомеостаза.

197022, Санкт-Петербург, ул. Л. Толстого, д. 17. 

Тел.: (812)3386901

Olga V. Galkina, PhD in Biology, Center Laboratory of Biochemical Homeostasis, Head

197022, Leo Tolstoy st. 17, build 54

Phone: (812)3386901

ovgalkina@mail.ruhttps://orcid.org/0000-0003-0634-267XТимшинаЕ. И.TimshinaE. I.

Тимшина Евгения Ивановна, биохимик-технолог

196006, Санкт-Петербург, ул. Цветочная, д. 16, лит. М, 2-й этаж

Тел.: 8(921)4019054

Eugenia I. Timshina, Biochemistry technologist

196006, Tsvetochnaya st. 16, 

Phone: 8(921)4019054

eugenia.timshina@gmail.comhttps://orcid.org/0000-0001-8491-7016ЗубинаИ. М.ZubinaI. M.

Зубина Ирина Михайловна, канд. биол. наук

197022, Санкт-Петербург, ул. Л. Толстого, д. 17. 

Тел.: (812)3386901

Irina M. Zubina, PhD in Biology, Clinical Research Center Laboratory of Biochemical Homeostasis

197022, Leo Tolstoy st. 17, build54

Phone: (812)3386901

zubina@list.ruhttps://orcid.org/0000-0003-1032-5653МихееваА.. Ю.MiheevaA. U.

Михеева Алена Юрьевна, канд. хим. наук, Научно-исследовательский отдел государственных эталонов в области органического и неорганического анализа, ведущий научный сотрудник

190005, Санкт-Петербург, Московский пр., д. 19. 

Тел.: 8(911)2507022

Alena U. Miheeva, PhD in Chemistry, Leading researcher, Research department of state standards in the fi eld of organic and inorganic analysis.

196006, Moskovsky pr. 19, 

Phone: 8(911)2507022

may@b10.vniim.ruhttps://orcid.org/0000-0002-2152-9881БердичевскийГ. М.BerdichevskyG. M.

Бердичевский Григорий Михайлович, Научно-исследовательский отдел государственных эталонов в области органического и неорганического анализа, инженер 2-й категории.

190005, Санкт-Петербург, Московский пр., д. 19. 

Тел.: 8(812)-2517601

Grigory M. Berdichevsky, Engineer 2nd category, Research department of state standards in the fi eld of organic and inorganic analysis

196006, Moskovsky pr. 19

Phone: 8(812)2517601

bgm@b10.vniim.ruНаучно-исследовательский институт нефрологии, Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. ПавловаРоссияInstitute of Nephrology Scientific and Clinical Research Center of The First Pavlov State Medical UniversityRussian FederationОбщество с ограниченной ответственностью «Научно-производственная фирма «АБРИС+»РоссияLimited Liability Company «Scientific and Production Firm «ABRIS+»Russian FederationХимико-аналитический центр «Арбитраж», Всероссийский научно-исследовательский институт метрологии им. Д.И. МенделееваРоссияChemical Analytical Center «Arbitrage» of The D.I. Mendeleev All-Russian Institute for MetrologyRussian Federation2020260620202442136Copyright © Каюков И.Г., Галкина О.В., Тимшина Е.И., Зубина И.М., Михеева А.Ю., Бердичевский Г.М., 20202020Каюков И.Г., Галкина О.В., Тимшина Е.И., Зубина И.М., Михеева А.Ю., Бердичевский Г.М.Kayukov I.G., Galkina O.V., Timshina E.I., Zubina I.M., Miheeva A.U., Berdichevsky G.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1855

Скорость клубочковой фильтрации (СКФ) является общепризнанным показателем функционального состояния почек. В медицинской практике существуют различные подходы для измерения СКФ. Однако, несмотря на почти столетнюю историю, далеко не все методологические проблемы оценки СКФ в клинической практике решены. Наиболее физиологически обоснованные («референтные») методы неприемлемы в рутинной практике из-за сложности и дороговизны. Клиницистам приходится опираться в основном на результаты суррогатных способов, большинство из которых в качестве гломерулотропного тест-агента предполагают использование эндогенного креатинина. Поэтому точность определения концентрации этого метаболита в биологических средах (особенно в сыворотке крови) зачастую решающим образом определяет надежность оценки СКФ. Производители наборов реагентов для определения креатинина должны принимать во внимание современные требования к точности и прослеживаемости результатов измерений и обеспечивать соответствие своей продукции международным нормам.

Glomerular filtration rate (GFR) is a recognized indicator of the functional status of the kidneys. In medical practice, there are various approaches for measuring GFR. However, despite the nearly 100-year history, not all methodological problems of evaluating GFR in clinical practice have been solved. The most physiologically justified (“reference”) methods are not acceptable in routine practice because of the complexity and high cost. Therefore, clinicians have to rely mainly on the results of surrogate methods, most of which use endogenous creatinine as a glomerulotropic test agent. Therefore, the accuracy of determining the concentration of this metabolite in biological media (especially in serum) is often crucially determined by the reliability of the GFR assessment. Manufacturers of creatinine reagent kits should take into account current requirements for accuracy and traceability of measurement results and ensure that their products comply with international standards.

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The authors declare that there are no conflicts of interest present.