nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.36485/1561-6274-2020-24-6-85-92nefr-1905Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИ. ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL ARTICLES. EXPERIMENTAL INVESTIGATIONКанонический WNT сигналинг и ремоделирование миокарда при артериальной гипертензии и хронической дисфункции почекСanonical WNT signaling and myocardial remodeling in arterial hypertension and chronic kidney dysfunctionhttps://orcid.org/0000-0003-1969-1959БогдановаЕ. О.BogdanovaE. O.

Богданова Евдокия Олеговна, канд. биол. наук, Научно-исследовательский институт нефрологии, лаборатория биохимического гомеостаза

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54Тел.: +7(812)338-69-31 

Evdokia Bogdanova, PhD, Research Institute of Nephrology, Laboratory of Biochemical Homeostasis

197022, Saint Petersburg, L. Tolstoy st., 17, build. 54Phone: +7(812)338-69-31 

evdokia.bogdanova@gmail.comhttps://orcid.org/0000-0002-7532-2405БересневаО. Н.BeresnevaO. N.

Береснева Ольга Николаевна, канд. биол. наук, Научно-исследовательский институт нефрологии, лаборатория клинической физиологии почки

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54Тел.: +7(812)338-69-31 

Olga N. Beresneva, PhD, Research Institute of Nephrology, Laboratory of Kidney Clinical Physiology

197022, Saint Petersburg, L. Tolstoy st., 17, build. 54Phone: +7(812)338-69-31 

beresnevaolga@list.ruhttps://orcid.org/0000-0001-8491-7016ЗубинаИ. М.ZubinaI. M.

Зубина Ирина Михайловна, канд. биол. наук, Научно-исследовательский институт нефрологии, лаборатория биохимического гомеостаза

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54Тел.: +7(812)338-69-31 

Irina M. Zubina PhD, Research Institute of Nephrology, Laboratory of Biochemical Homeostasis

197022, Saint Petersburg, L. Tolstoy st., 17, build. 54Phone: +7(812)338-69-31 

zubina@list.ruhttps://orcid.org/0000-0003-0188-5173ИвановаГ. Т.IvanovaG. T.

Иванова Галина Тажимовна, канд. биол. наук, лаборатория физиологии сердечно-сосудистой и лимфатической системы

199034, Санкт-Петербург, наб. Макарова, д. 6Тел.: +7(812)328-11-01 

Galina T. Ivanova, PhD, Laboratory of cardiovascular and lymphatic systems physiology

199034, Saint Petersburg, seafront Makarova, build. 6Phone: +7(812)328-11-01 

pavlov.institute@infran.ruhttps://orcid.org/0000-0002-4526-8671ПарастаеваМ. М.ParastaevaM. M.

Парастаева Марина Магрезовна, канд. биол. наук, Научно-исследовательский институт нефрологии, лаборатория клинической физиологии почки

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54Тел.: +7(812)338-69-01 

Marina M. Parastaeva, PhD, Research Institute of Nephrology, Laboratory of Kidney Clinical Physiology

197022, Saint Petersburg, L. Tolstoy st., 17, build. 54Phone: +7(812)338-69-01 

beresnevaolga@list.ruhttps://orcid.org/0000-0001-7265-7392ГалкинаО. В.GalkinaO. V.

Галкина Ольга Владимировна, канд. биол. наук, Научно-исследовательский институт нефрологии, лаборатория биохимического гомеостаза

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54Тел.: +7(812)338-69-31 

Olga V. Galkina, PhD, Research Institute of Nephrology, Laboratory of Biochemical Homeostasis, Head

197022, Saint Petersburg, L. Tolstoy st., 17, build. 54Phone: +7(812)338-69-31 

ovgalkina@mail.ruhttps://orcid.org/0000-0002-7179-5520ДобронравовВ. А.DobronravovV. A.

Проф. Добронравов Владимир Александрович, д-р мед. наук, Научно-исследовательский институт нефрологии, заместитель директора

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54Тел.: +7(812)338-69-01 

Prof. Vladimir A. Dobronravov, MD, PhD, DSc, Research Institute of Nephrology, Vice Director

197022, Saint Petersburg, L. Tolstoy st., 17, build. 54Phone: +7(812)338-69-01 

dobronravov@nephrolog.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И.П. ПавловаРоссияPavlov UniversityRussian FederationИнститут физиологии имени И.П. Павлова РАНРоссияPavlov Institute of Physiology RASRussian Federation2020251120202468592Copyright © Богданова Е.О., Береснева О.Н., Зубина И.М., Иванова Г.Т., Парастаева М.М., Галкина О.В., Добронравов В.А., 20202020Богданова Е.О., Береснева О.Н., Зубина И.М., Иванова Г.Т., Парастаева М.М., Галкина О.В., Добронравов В.А.Bogdanova E.O., Beresneva O.N., Zubina I.M., Ivanova G.T., Parastaeva M.M., Galkina O.V., Dobronravov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1905ремоделирование миокардагипертрофия миокардакардиомиоцитыхроническая болезнь почекартериальная гипертензияKlothoканонический сигнальный путь WNTβ-катенинcardiac hypertrophychronic kidney diseasearterial hypertensionbeta-cateninKlothocanonical WNT signaling pathwayReferencesLevy D, Garrison RJ, Savage DD et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham heart study. N Engl J Med 1990;322:1561-1566. doi: 10.1056/NEJM199005313222203Levy D, Garrison RJ, Savage DD et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham heart study. N Engl J Med 1990;322:1561-1566. doi: 10.1056/NEJM199005313222203London GM, Pannier B, Guerin AP et al. Cardiac hypertrophy, aortic compliance, peripheral resistance and wave reflection in end-stage renal disease. Comparative effects of ACE inhibition and calcium channel blockade. Circulation 1994;90:2786-2796. doi: 10.1161/01.cir.90.6.2786.London GM, Pannier B, Guerin AP et al. Cardiac hypertrophy, aortic compliance, peripheral resistance and wave reflection in end-stage renal disease. Comparative effects of ACE inhibition and calcium channel blockade. Circulation 1994;90:2786-2796. doi: 10.1161/01.cir.90.6.2786.Kaesler N, Babler A, Floege J et al. Cardiac Remodeling in Chronic Kidney Disease. Toxins (Basel) 2020;12(3):161. doi: 10.3390/toxins12030161Kaesler N, Babler A, Floege J et al. Cardiac Remodeling in Chronic Kidney Disease. Toxins (Basel) 2020;12(3):161. doi: 10.3390/toxins12030161Buckalew VM, Berg RL, Wang SR et al. Prevalence of hypertension in 1,795 subjects with chronic renal disease: the modification of diet in renal disease study baseline cohort. Modification of diet in renal disease study group. Am J Kidney Dis 1996;28(6):811-21. doi:10.1016/s0272-6386(96)90380-7Buckalew VM, Berg RL, Wang SR et al. Prevalence of hypertension in 1,795 subjects with chronic renal disease: the modification of diet in renal disease study baseline cohort. Modification of diet in renal disease study group. Am J Kidney Dis 1996;28(6):811-21. doi:10.1016/s0272-6386(96)90380-7Wu-Wong JR. Vitamin D therapy in cardiac hypertrophy and heart failure. Curr Pharm Des 2011;17(18):1794-1807. doi: 10.2174/138161211796391038Wu-Wong JR. Vitamin D therapy in cardiac hypertrophy and heart failure. Curr Pharm Des 2011;17(18):1794-1807. doi: 10.2174/138161211796391038Yang K, Wang C, Nie L et al. Klotho protects against indoxyl sulphate-induced myocardial hypertrophy. Journal of the American Society of Nephrology 2015;26 (10):2434-2446. doi: 10.1681/ASN.2014060543.Yang K, Wang C, Nie L et al. Klotho protects against indoxyl sulphate-induced myocardial hypertrophy. Journal of the American Society of Nephrology 2015;26 (10):2434-2446. doi: 10.1681/ASN.2014060543.Богданова ЕО, Береснева ОН, Зубина ИМ и др. Ингибиторы канонического сигнального пути Wnt и нарушение обмена неорганического фосфата при экспериментальной дисфункции почек. Нефрология 2019;23(6):83-91Bogdanova EO, Beresneva ON, Zubina IM et al. Inhibitors of canonical Wnt signaling pathway and inorganic phosphate imbalance in experimental chronic kidney disease. Nephrology (SaintPetersburg) 2019;23(6):83-91 (In Russ.)Sassi Y, Avramopoulos P, Ramanujam D et al. Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. Nat Commun 2017;8(1):1614. doi: 10.1038/s41467-017-01737-4.Sassi Y, Avramopoulos P, Ramanujam D et al. Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. Nat Commun 2017;8(1):1614. doi: 10.1038/s41467-017-01737-4.Wang Y, Zhou CJ, Liu Y et al. Wnt Signaling in Kidney Development and Disease. Prog Mol Biol Transl Sci 2018;153:181-207. doi: 10.1016/bs.pmbts.2017.11.019Wang Y, Zhou CJ, Liu Y et al. Wnt Signaling in Kidney Development and Disease. Prog Mol Biol Transl Sci 2018;153:181-207. doi: 10.1016/bs.pmbts.2017.11.019Vite A, Radice G. N-cadherin/catenin complex as a master regulator of intercalated disc function. Cell Commun Adhes 2014;21(3):169-179. doi: 10.3109/15419061.2014.908853Vite A, Radice G. N-cadherin/catenin complex as a master regulator of intercalated disc function. Cell Commun Adhes 2014;21(3):169-179. doi: 10.3109/15419061.2014.908853Cox RT, Kirkpatrick C, Peifer M. Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during drosophila embryogenesis. J Cell Biol 1996;134:133-148. doi: 10.1083/jcb.134.1.133Cox RT, Kirkpatrick C, Peifer M. Armadillo is required for adherens junction assembly, cell polarity, and morphogenesis during drosophila embryogenesis. J Cell Biol 1996;134:133-148. doi: 10.1083/jcb.134.1.133Syed H, Michael A, Andreucci M et al. Stabilization of betacatenin by a Wnt-independent mechanism regulates cardiomyocyte growth. J Proc Natl Acad Sci USA 2003;100:4610-4615. doi: 10.1073/pnas.0835895100Syed H, Michael A, Andreucci M et al. Stabilization of betacatenin by a Wnt-independent mechanism regulates cardiomyocyte growth. J Proc Natl Acad Sci USA 2003;100:4610-4615. doi: 10.1073/pnas.0835895100Xin C, Shevtsov SP, Hsich E et al. The ß-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. J Mol Cell Biol 2006;26:4462-4473. doi: 10.1128/MCB.02157-05Xin C, Shevtsov SP, Hsich E et al. The ß-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. J Mol Cell Biol 2006;26:4462-4473. doi: 10.1128/MCB.02157-05Богданова ЕО, Береснева ОН, Галкина ОВ и др. Витамин D и фибропластические процессы в миокарде спонтанно гипертензивных крыс с начальными стадиями хронической дисфункции почек. Артериальная гипертензия 2020;26(1):107-118. doi: 10.18705/1607-419X-2020-26-1-107-118Bogdanova EO, Beresneva ON, Galkina OV et al. Vitamin D and fibroplastic processes in the myocardium of spontaneously hypertensive rats with the initial stages of chronic renal dysfunction. Arterial hypertension 2020;26(1):107-118 (In Russ.). doi: 10.18705/1607-419X-2020-26-1-107-118Schillaci G, Verdecchia P, Porcellati C. Continuous relation between left ventricular mass and cardiovascular risk in essential hypertension. Hypertension 2000;35(2):580-586. doi: 10.1161/01.hyp.35.2.580.Schillaci G, Verdecchia P, Porcellati C. Continuous relation between left ventricular mass and cardiovascular risk in essential hypertension. Hypertension 2000;35(2):580-586. doi: 10.1161/01.hyp.35.2.580.Weber K, Janicki J, Shroff S et al. Collagen Remodeling of the Pressure-Overloaded, Hypertrophied Nonhuman Primate Myocardium. Circulation Research 1988;62:757-765. doi: 10.1161/01.RES.62.4.757Weber K, Janicki J, Shroff S et al. Collagen Remodeling of the Pressure-Overloaded, Hypertrophied Nonhuman Primate Myocardium. Circulation Research 1988;62:757-765. doi: 10.1161/01.RES.62.4.757Добронравов ВА. Фосфат, почки, кости и сердечнососудистая система. Нефрология 2016;20(4):10-24Dobronravov VA. Phosphate, kidneys, bones and cardiovascular system. Nephrology (Saint-Petersburg) 2016;20(4):10-24 (In Russ.)Zheng Q, Chen P, Xu Z et al. Expression and redistribution of β-catenin in the cardiac myocytes of left ventricle of spontaneously hypertensive rat. Journal of Molecular Histology 2013;44:565-573. doi: 10.1007/s10735-013-9507-6Zheng Q, Chen P, Xu Z et al. Expression and redistribution of β-catenin in the cardiac myocytes of left ventricle of spontaneously hypertensive rat. Journal of Molecular Histology 2013;44:565-573. doi: 10.1007/s10735-013-9507-6Zhao Y, Wang Ch, Wang C et al. An essential role for Wnt/βcatenin signaling in mediating hypertensive heart disease. Sci Rep 2018;8:8996. doi: 10.1038/s41598-018-27064-2Zhao Y, Wang Ch, Wang C et al. An essential role for Wnt/βcatenin signaling in mediating hypertensive heart disease. Sci Rep 2018;8:8996. doi: 10.1038/s41598-018-27064-2Lai CH, Pandey S, Hsuan C et al. β-catenin/LEF1/IGFIIR Signaling Axis Galvanizes the Angiotensin-II-induced Cardiac Hypertrophy. Int J Mol Sci 2019;20(17):4288. doi: 10.3390/ijms20174288Lai CH, Pandey S, Hsuan C et al. β-catenin/LEF1/IGFIIR Signaling Axis Galvanizes the Angiotensin-II-induced Cardiac Hypertrophy. Int J Mol Sci 2019;20(17):4288. doi: 10.3390/ijms20174288Lindberg K, Amin R, Moe OW et al. The kidney is the principal organ mediating klotho effects. J Am Soc Nephrol 2014;25(10):2169-2175. doi: 10.1681/ASN.2013111209Lindberg K, Amin R, Moe OW et al. The kidney is the principal organ mediating klotho effects. J Am Soc Nephrol 2014;25(10):2169-2175. doi: 10.1681/ASN.2013111209Cerasola G, Nardi E, Palermo A et al. Epidemiology and pathophysiology of left ventricular abnormalities in chronic kidney disease: a review. J Nephrol 2011;24(1):1-10. doi: 10.5301/jn.2010.2030Cerasola G, Nardi E, Palermo A et al. Epidemiology and pathophysiology of left ventricular abnormalities in chronic kidney disease: a review. J Nephrol 2011;24(1):1-10. doi: 10.5301/jn.2010.2030Xie J, Cha SK, An SW et al. Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun 2012;3:1238-1240. doi: 10.1038/ncomms2240.Xie J, Cha SK, An SW et al. Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun 2012;3:1238-1240. doi: 10.1038/ncomms2240.Xie J, Yoon J, An SW et al. Soluble klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate. J Am Soc Nephrol 2015;26:1150-1160. doi: 10.1681/ASN.2014040325Xie J, Yoon J, An SW et al. Soluble klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate. J Am Soc Nephrol 2015;26:1150-1160. doi: 10.1681/ASN.2014040325Богданова ЕО, Семенова НЮ, Береснева ОН и др. Повышенная экспрессия TRPC6 в кардиомиоцитах как один из механизмов гипертрофии миокарда при дисфункции почек. Нефрология 2020;24(4):93-101. doi: 10.36485/1561-62742020-24-4-93-101Bogdanova EO, Semenova NYu, Beresneva ON et al. Increased expression of TRPC6 in cardiomyocytes as one of the mechanisms of myocardial hypertrophy in renal dysfunction. Nephrology (Saint Petersburg) 2020;24(4):93-101. (In Russ.) doi: 10.36485/1561-6274-2020-24-4-93-101Liu H, Fergusson MM, Castilho RM et al. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 2007;317(5839):803-806. doi: 10.1126/science.1143578Liu H, Fergusson MM, Castilho RM et al. Augmented Wnt signaling in a mammalian model of accelerated aging. Science 2007;317(5839):803-806. doi: 10.1126/science.1143578

The authors declare that there are no conflicts of interest present.