nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.36485/1561-6274-2021-25-2-35-42nefr-1941Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРоль эпигенетических механизмов в патогенезе диабетической нефропатииThe role of epigenetic mechanisms in the pathogenesis of diabetic nephropathyhttps://orcid.org/0000-0003-4973-039XАйтбаевК. А.AitbaevK. A.

Айтбаев Кубаныч Авенович, д-р мед. наук

720040, Кыргызстан, г. Бишкек, ул. Т. Молдо, д. 3

Тел.: (312) 66-25-13

Kubanych A. Aitbaev, MD, PhD, DMedSci; Head of the Department of Pathological Physiology; Member of the Board of the Society of Chronic Kidney Disease Specialists

720040, Kyrgyzstan, Bishkek, T. Moldo, Street, 3

Phone: (312) 66-25-13

kaitbaev@yahoo.comhttps://orcid.org/0000-0001-8513-9279МуркамиловИ. Т.MurkamilovI. T.

Муркамилов Илхом Торобекович, канд. мед. наук, исполняющий обязанности доцента кафедры факультетской терапии; старший преподаватель кафедры терапии №2 медицинского факультета

720020, г. Бишкек, ул. Ахунбаева, д. 92

Тел.: (312) 62-09-91

Ilkhom T. Murkamilov, MD, PhD; acting associate professor of the Department of faculty therapy; Senior lecturer; Chairman of the board of Chronic Kidney Disease specialists

720020, Kyrgyzstan, Bishkek, Akhunbaev Street, 92

Phone: (312) 62-09-91

murkamilov.i@mail.ruhttps://orcid.org/0000-0002-2682-4417ФоминВ. В.FominV V

Чл.-кор. РАН Виктор Викторович Фомин, д-р мед. наук, зав. каф. факультетской терапии №1, проректор по клинической работе и дополнительному профессиональному образованию

119146, Россия, Москва, ул. Большая Пироговская, д. 6

Тел.: 8 (499) 248-62-22

Сorresponding member of RAS Viktor V. Fomin, MD, PhD, DMedSci; Head of the Department of Faculty Therapy No.1

119146, Russia, Moscow, 6 Bolshaya Pirogovskaya, Street 6

Phone: +7 (499) 248-62-22

fomin@mma.ruhttps://orcid.org/0000-0002-7653-0433МуркамиловаЖ. А.MurkamilovaZh. A.

Муркамилова Жамила Абдилалимовна, заочный аспирант

Кыргызстан, 720000, г. Бишкек, ул. Киевская, д. 44

Тел.: (+996) 552435009

Correspondence graduate student Zhamila A. Murkamilova, MD; Department of Therapy No. 2

720000, Kyrgyzstan, Bishkek, Kiev, Street, 44

Phone: (+996) 552435009

murkamilovazh.t@mail.ruhttps://orcid.org/0000-0003-0632-6653ЮсуповФ. А.YusupovF. A.

Фуркат Абдулахатович Юсупов, д-р мед. наук, Зав. каф. неврологии, психиатрии и нейрохирургии медицинского факультета Ошского; Главный невролог Южного региона

714000, г. Ош, ул. Ленина, д. 331

Тел.: (+996) 557202071

Furkat A. Yusupov, MD, PhD; Head of the Department of neurology, psychiatry and medicinal genetics of medicinal

faculty; Board member of Chronic Kidney Disease specialists

714000, Kyrgyzstan, Osh, Lenin Street, 331

Phone: (+996) 557202071

furcat_y@mail.ruНИИ молекулярной биологии и медицины при Национальном центре кардиологии и терапии им. акад. Мирсаида МиррахимоваКыргызстанResearch Institute of Molecular Biology and MedicineKyrgyzstanКыргызская государственная медицинская академия им. И.К. Ахунбаева; Кыргызско-Российский славянский университетКыргызстанI.K.Akhunbaev Kyrgyz State Medical AcademyKyrgyzstanПервый Московский государственный медицинский университет им. И.М. СеченоваРоссияI.M. Sechenov First Moscow State Medical UniversityRussian FederationКыргызско-Российский Славянский университетКыргызстанKyrgyz Russian Slavic UniversityKyrgyzstanОшский государственный университетКыргызстанOsh State UniversityKyrgyzstan2021130220212523542Copyright © Айтбаев К.А., Муркамилов И.Т., Фомин В.В., Муркамилова Ж.А., Юсупов Ф.А., 20212021Айтбаев К.А., Муркамилов И.Т., Фомин В.В., Муркамилова Ж.А., Юсупов Ф.А.Aitbaev K.A., Murkamilov I.T., Fomin V.V., Murkamilova Z.A., Yusupov F.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/1941

Диабетическая нефропатия (ДН) является хроническим осложнением диабета и наиболее распространенной причиной развития терминальной стадии почечной недостаточности (ТСПН). Были предложены многочисленные факторы, как способствующие развитию ДН, так и участвующие в её патогенезе. Однако молекулярные механизмы, которые приводят к развитию ДН, остаются на сегодняшний день не вполне понятными. В последнее время с развитием высокопроизводительных технологий появляются доказательства, свидетельствующие об эпигенетических механизмах регуляции экспрессии генов, включая метилирование ДНК, некодирующие РНК и гистоновые модификации, которые играют ключевую роль в патогенезе ДН посредством вторичной регуляции генов. Все эти данные могут способствовать созданию новых, более эффективных диагностических и терапевтических технологий для ДН.

Diabetic nephropathy (DN) is a chronic complication of diabetes and the most common cause of the end-stage renal disease (ESRD). Numerous factors have been considered, both contributing to the development of DN, and participating in its pathogenesis. However, to date, the molecular mechanisms, that lead to the development of DN, remain not fully understood. Recently, with the development of high-performance technologies, evidence demonstrating epigenetic mechanisms of regulation of gene expression, including DNA methylation, non-coding RNAs, and histone modifications that play a key role in the pathogenesis of DN through the secondary regulation of genes are starting to appear. All these data can contribute to the creation of new, more effective diagnostic and therapeutic technologies for DN.

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The authors declare that there are no conflicts of interest present.