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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nefr</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology (Saint-Petersburg)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-6274</issn><issn pub-type="epub">2541-9439</issn><publisher><publisher-name>Pavlov First Saint-Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36485/1561-6274-2022-26-2-72-76</article-id><article-id custom-type="elpub" pub-id-type="custom">nefr-2117</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ. КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES. CLINICAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>КОМПЛЕКСНАЯ ОЦЕНКА ФУНКЦИОНАЛЬНОГО СОСТОЯНИЯ ПОЧЕК И ГЕМОДИНАМИКИ В ПРОГНОЗИРОВАНИИ СЕРДЕЧНО-СОСУДИСТОГО РИСКА У БОЛЬНЫХ С ХРОНИЧЕСКИМ ПИЕЛОНЕФРИТОМ И АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>COMPREHENSIVE ASSESSMENT OF THE FUNCTIONAL STATE OF THE KIDNEYS AND HEMODYNAMICS IN THE PROGNOSIS OF CARDIOVASCULAR RISK IN PATIENTS WITH CHRONIC PYELONEPHRITIS AND ARTERIAL HYPERTENSION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2026-915X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Осколков</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Oskolkov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Осколков Сергей Анатольевич, проф., д-р мед. наук, кафедра пропедевтической и факультетской терапии</p><p>625023, г. Тюмень, ул. Одесская, д. 54Тел.:+79068255742</p></bio><bio xml:lang="en"><p>Sergey A. Oskolkov, prof.  MD, PhD, DMedSci, Department of Propaedeutic and Faculty Therapy</p><p>625023, Tyumen, Odesskaya st., 54Phone: +79068255742</p></bio><email xlink:type="simple">oskolkov65@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6824-0025</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пакетов</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Paketov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пакетов Сергей Анатольевич, проф., кафедра пропедевтической и факультетской терапии</p><p>625023, г. Тюмень, ул. Одесская, д. 54Тел.:+7950497839</p></bio><bio xml:lang="en"><p>Sergey A. Paketov, ass.,  MD, PhD, Department of Propaedeutic and Faculty Therapy</p><p>625023, Tyumen, Odesskaya st., 54Phone: +79504978390</p></bio><email xlink:type="simple">paketov1995@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7228-6197</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жмуров</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhmurov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жмуров Владимир Александрович, проф., д-р мед. наук, академик РАЕ, кафедра пропедевтической и факультетской терапии.</p><p>Тел.: +79044974495625023, г. Тюмень, ул. Одесская, д. 54</p></bio><bio xml:lang="en"><p>Vladimir A. Zhmurov, prof., MD, PhD, DMedSci, Department of Propaedeutic and Faculty Therapy</p><p>625023, Tyumen, Odesskaya st., 54Phone: +79044974495</p></bio><email xlink:type="simple">zhmurovva@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3167-5310</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жмуров</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhmurov</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жмуров Денис Владимирович, доц., канд. мед. наук, кафедра пропедевтической и факультетской терапии.</p><p>625023, г. Тюмень, ул. Одесская, д. 54Тел.: +79091813104</p></bio><bio xml:lang="en"><p>Denis V. Zhmurov, doc.,  MD, PhD, Department of Propaedeutic and Faculty Therapy</p><p>625023, Tyumen, Odesskaya st., 54Phone: +79091813104</p></bio><email xlink:type="simple">zhmdenis@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3192-2257</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>P. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванова Полина Витальевна, студ.</p><p>625023, г. Тюмень, ул. Одесская, д. 54Тел.: +79199337800</p></bio><bio xml:lang="en"><p>Polina V. Ivanova, stud.</p><p>625023, Tyumen, Odesskaya st., 54Phone: +79199337800</p></bio><email xlink:type="simple">ivanovapv00@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3074-1884</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евсеев</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Evseev</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Евсеев Максим Валерьевич, студ</p><p>625023, г. Тюмень, ул. Одесская, д. 54Тел.: +79827820416</p></bio><bio xml:lang="en"><p>Maxim V. Evseev, stud.</p><p>625023, Tyumen, Odesskaya st., 54Phone: +79827820416</p></bio><email xlink:type="simple">max-evseev72@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тюменский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tyumen State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>23</day><month>06</month><year>2022</year></pub-date><volume>26</volume><issue>2</issue><fpage>72</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Осколков С.А., Пакетов С.А., Жмуров В.А., Жмуров Д.В., Иванова П.В., Евсеев М.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Осколков С.А., Пакетов С.А., Жмуров В.А., Жмуров Д.В., Иванова П.В., Евсеев М.В.</copyright-holder><copyright-holder xml:lang="en">Oskolkov S.A., Paketov S.A., Zhmurov V.A., Zhmurov D.V., Ivanova P.V., Evseev M.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephrolog.ru/jour/article/view/2117">https://journal.nephrolog.ru/jour/article/view/2117</self-uri><abstract><p>ВВЕДЕНИЕ. В последние годы наблюдается увеличениe числа пациентов с хронической болезнью почек (ХБП), в том числе, за счет увеличения распространенности артериальной гипертензии (АГ). При хроническом пиелонефрите ускоренное развитие изменений сердечно-сосудистой системы на фоне снижения скорости клубочковой фильтрации может быть обусловлено артериальной гипертензией (АГ). ЦЕЛЬ: оценить состояние центральной гемодинамики, показатели секреторной и экскреторной функции почек, при сочетании вторичного хронического пиелонефрита и АГ. ПАЦИЕНТЫ И МЕТОДЫ. Обследовали 81 пациента с вторичным хроническим пиелонефритом, обусловленным нефролитиазом в сочетании с АГ в фазе неполной клинико-лабораторной ремиссии. Возраст пациентов – от 25 до 60 лет. Были проведены комплексная оценка функционального состояния почек и гемодинамики с учетом данных анамнеза, клинических и параклинических методов обследования. РЕЗУЛЬТАТЫ. По данным динамической нефросцинтиграфии выявлено удлинение экскреторной фазы при сохранности секреторной фазы в обеих почках. Снижение расчетной скорости клубочковой фильтрации отмечено уже при АГ1 степени. По данным эхокардиографии отмечены нарушения диастолической функции ЛЖ при сохранной систолической функции левого желудочка. ЗАКЛЮЧЕНИЕ. Мы обнаружили, что при ХБП 1 стадии сохранение секреторной функции сочетается с замедлением экскреторной функции обеих почек, что может быть связано с процессами склерозирования тубуло-интерстициальной зоны почек на фоне хронического воспалительного процесса. Полученные данные позволяют высказать мысль о целесообразности комплексного кардиоренального динамического контроля уже в дебюте ХБП, что будет способствовать улучшению эффективности нефро- и кардиопротективных мероприятий в данной когорте пациентов.</p></abstract><trans-abstract xml:lang="en"><p>BACKGROUND. In recent years, there has been an increase in the number of patients with chronic kidney disease (CKD), including due to the prevalence of arterial hypertension (AH). In chronic pyelonephritis, the accelerated development of changes in the cardiovascular system at the background of a decrease in glomerular filtration rate may be due to arterial hypertension (AH). THE AIM: to assess the state of central hemodynamics, indicators of secretory and excretory kidney function, in patients with a combination of secondary chronic pyelonephritis and AH. PATIENTS AND METHODS. 81 patients with secondary chronic pyelonephritis caused by nephrolithiasis in combination with hypertension in the phase of incomplete clinical and laboratory remission were examined. The age of patients is from 25 to 60 years. A comprehensive assessment of the functional state of the kidneys and hemodynamics was carried out, taking into account the data of anamnesis, clinical and paraclinical examination methods. RESULTS. According to the data of dynamic nephroscintigraphy, an elongation of the excretory phase was revealed with the preservation of the secretory phase in both kidneys. A decrease in the estimated glomerular filtration rate was noted already at AG1 degree. According to echocardiography, violations of LV diastolic function were noted with preserved systolic function of the left ventricle. CONCLUSION. We found that in stage 1 CKD, the preservation of secretory function is combined with a slowdown in the excretory function of both kidneys, which may be associated with the processes of sclerosis of the tubulo-interstitial zone of the kidneys at the background of a chronic inflammatory process. The data obtained allow us to express the idea of the expediency of complex cardiorenal dynamic control already in the debut of CKD, which will contribute to improving the effectiveness of nephro- and cardioprotective measures in this cohort of patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая болезнь почек</kwd><kwd>хронический пиелонефрит</kwd><kwd>артериальная гипертензия</kwd><kwd>нефролитиаз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic kidney disease</kwd><kwd>nephrolithiasis</kwd><kwd>chronic pyelonephritis</kwd><kwd>arterial hypertension</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Жмуров ДВ, Парфентева МА, Семенова ЮВ и др. Хроническая болезнь почек. Colloquium-journal 2020;12(64). doi:10.24411/2520-6990-2020-11792</mixed-citation><mixed-citation xml:lang="en">Zhmurov DV, Parfentieva MA, Semenova YV et al. 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