nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2017-21-1-9-18nefr-216Research ArticleПЕРЕДОВАЯ СТАТЬЯLEADING ARTICLEGPR91: РАСШИРЕНИЕ ПРЕДСТАВЛЕНИЙ О МЕТАБОЛИТАХ ЦИКЛА КРЕБСАGPR91: EXPANDING THE FRONTIERS OF KREBS CYCLE INTERMEDIATESде К. ФонсекаМ.De C. FonsecaM.

Отдел физиологии и биофизики

Department of Physiology and Biophysics

Av. Antonio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901

hp.matheus@gmail.comАгуйарК. Дж.AguiarC. J.carlajeane33@hotmail.comда Роча ФранкоЖ. А.Da Rocha FrancoJ. A.

Отдел физиологии и биофизики

Department of Physiology and Biophysics

Av. Antonio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901

joaoantoniodarochafranco@hotmail.comГинголдР. Н.GingoldR. N.

Отдел физиологии и биофизики

Department of Physiology and Biophysics

Av. Antonio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901

r.n.gingold@gmail.comЛейтеМ. Ф.LeiteM. F.

Отдел физиологии и биофизики

Department of Physiology and Biophysics

Av. Antonio Carlos 6627, Belo Horizonte, MG, CEP: 31270-901

leitemd@ufmg.brФедеральный университет Минас-ЖерайсаБразилияFederal University of Minas GeraisBrazilУниверситет Estácio de Sá, Бело Хоризонте, MGБразилияCentro Universitário Estácio de Sá, Belo Horizonte, MGBrazil201703032017211918Copyright © де К. Фонсека М., Агуйар К.Д., да Роча Франко Ж.А., Гинголд Р.Н., Лейте М.Ф., 20172017де К. Фонсека М., Агуйар К.Д., да Роча Франко Ж.А., Гинголд Р.Н., Лейте М.Ф.de C. Fonseca M., Aguiar C.J., da Rocha Franco J.A., Gingold R.N., Leite M.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/216

Цикл лимонной кислоты со времени его открытия рассматривали как центральную часть метаболизма и энергетического гомеостаза клетки. Находясь главным образом в митохондриальном матриксе, некоторые из промежуточных продуктов цикла Кребса присутствуют также и в кровотоке. В настоящее время имеются свидетельства того, что метаболиты цикла Кребса играют важную роль и за пределами цикла. Так, сукцинат является внеклеточным лигандом сопряженного с G-белком рецептора, известного как GPR91, который экспрессирован в почках, печени, сердце, клетках сетчатки и, вероятно, во многих других тканях. Активация сукцинатом GPR91 вызывает целый ряд физиологических и патологических эффектов. Посредством связывания с GPR91 сукцинат участвует в регуляции кровяного давления, подавлении липолиза в белой жировой ткани, развитии васкуляризации сетчатки, гипертрофии миокарда и активации звездчатых клеток печени ишемизированными гепатоцитами. Данный обзор посвящен обсуждению этих эффектов. 

Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. Mainly found in the mitochondrial matrix, some of the intermediates of the Krebs cycle are also present in the blood stream. Currently, there are several reports that indicate functional roles for Krebs intermediates out of its cycle. Succinate, for instance, acts as an extracellular ligand by binding to a G-protein coupled receptor, known as GPR91, expressed in kidney, liver, heart, retinal cells and possibly many other tissues. Succinate activated GPR91 induces a wide array of physiological and pathological effects. Through GPR91, succinate is involved in functions such as regulation of blood pressure, inhibition of lipolysis in white adipose tissue, development of retinal vascularization, cardiac hypertrophy and activation of stellate hepatic cells by ischemic hepatocytes. Current review is dedicated to discussion of these effects. 

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The authors declare that there are no conflicts of interest present.