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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nefr</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology (Saint-Petersburg)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-6274</issn><issn pub-type="epub">2541-9439</issn><publisher><publisher-name>Pavlov First Saint-Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36485/1561-6274-2023-27-1-78-85</article-id><article-id custom-type="elpub" pub-id-type="custom">nefr-2199</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ (КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ)</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES (CLINICAL STUDIES AND EXPERIMENTAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Физическая работоспособность пациентов с хронической болезнью почек 5Д стадии и ишемической болезнью сердца</article-title><trans-title-group xml:lang="en"><trans-title>Physical performance of patients with chronic kidney disease stage 5D and coronary heart disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9455-1043</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коростелева</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Korosteleva</surname><given-names>N. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Юрьевна Коростелева, канд. мед. наук, старший научный сотрудник</p><p>НИИ нефрологии</p><p>197022</p><p>ул. Льва Толстого, д. 6–8</p><p>Санкт-Петербург</p><p>тел.: +7(911) 918-45-49</p></bio><bio xml:lang="en"><p>Natalya Yu. Korosteleva, MD, Ph.D, Senior Researcher</p><p>Research Institute of Nephrology</p><p>197022</p><p>st. Leo Tolstoy, 6–8</p><p>St. Petersburg</p><p>Phone: +7 (911) 918-45-49</p></bio><email xlink:type="simple">natkor_spb@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9455-1043</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Румянцев</surname><given-names>А. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Rumyantsev</surname><given-names>A. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александр Шаликович Румянцев, проф., д-р мед. наук</p><p>кафедра факультетской терапии</p><p>199106</p><p>21-я линия В. О., д. 8а</p><p>кафедра пропедевтики внутренних болезней</p><p>197022</p><p>ул. Льва Толстого, д. 6–8</p><p>Санкт-Петербург</p><p>тел.: +7 (812) 326-03-26</p><p>тел.: +7(911) 267-74-13</p></bio><bio xml:lang="en"><p>Aleksandr Sh. Rumyantsev, Prof., MD, PhD, DMedSci</p><p>Department of Faculty Therapy</p><p>199106</p><p>21st line V. O., 8a</p><p>Department of Propaedeutics of Internal Diseases</p><p>197022</p><p>st. Leo Tolstoy, 6–8</p><p>St. Petersburg</p><p>Tel.: +7 (812) 326-03-26</p><p>+7 (911) 267-74-13</p></bio><email xlink:type="simple">rash.56@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5722-8693</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хасун</surname><given-names>М. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Khasun</surname><given-names>M. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мохамад Халедович Хасун, доц., канд. мед. наук</p><p>кафедра пропедевтики внутренних болезней</p><p>197022</p><p>ул. Льва Толстого, д. 17, корп. 54</p><p>Санкт-Петербург</p><p>тел.: (812) 346-39-26</p></bio><bio xml:lang="en"><p>Mohamad Kh. Khasun, MD, Ph.D</p><p>Department of Propaedeutics of Internal Diseases</p><p>197022</p><p>st. L. Tolstoy, d. 17, building. 54</p><p>St. Petersburg</p><p>Phone: (812) 346-39-26</p></bio><email xlink:type="simple">nefrolog2013@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4768-3780</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лукичев</surname><given-names>Б. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Lukichev</surname><given-names>B. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Борис Георгиевич Лукичев, проф., д-р мед. наук</p><p>кафедра пропедевтики внутренних болезней</p><p>197022</p><p>ул. Льва Толстого, д. 17</p><p>Санкт-Петербург</p><p>тел.: (812)-234-01-65</p></bio><bio xml:lang="en"><p>Boris G. Lukichev, Prof., MD, PhD, DMedSci</p><p>Department of Propaedeutics of Internal Diseases</p><p>197022</p><p>st. L. Tolstoy, d. 17</p><p>St. Petersburg</p><p>Phone: (812) 234-01-65</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6624-5228</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедева</surname><given-names>Э. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedeva</surname><given-names>E. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эльвира Борисовна Лебедева, ст. лаборант</p><p>НИИ нефрологии</p><p>197022</p><p>ул. Льва Толстого, д. 6-8</p><p>Санкт-Петербург</p><p>тел.: 8951-643-35-54</p></bio><bio xml:lang="en"><p>Elvira B. Lebedeva, senior laboratory assistant</p><p>Research Institute of Nephrology</p><p>197022</p><p>st. Leo Tolstoy, d. 6-8</p><p>St. Petersburg</p><p>Phone: 8 951 643 35 54</p></bio><email xlink:type="simple">Lebedeva.elv@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0285-4179</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григорян</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Grigoryan</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Екатерина Викторовна Григорян, врач-диетолог </p><p>НИИ нефрологии</p><p>отд. гемодиализа</p><p>197022</p><p>ул. Льва Толстого, д. 6–8</p><p>Санкт-Петербург</p><p>тел.: 8-921-3264855</p></bio><bio xml:lang="en"><p>Ekaterina V. Grigoryan</p><p>Research Institute of Nephrology</p><p>197022</p><p>st. Leo Tolstoy, d. 6-8</p><p>St. Petersburg</p><p>Phone: 8 921 326 48 55</p></bio><email xlink:type="simple">kate-piter@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2704-679X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулаева</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulaeva</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Николаевна Кулаева, доц., канд мед наук</p><p>кафедра внутренних болезней, клинической фармакологии и нефрологии</p><p>195067</p><p>Пискаревский пр., д. 47</p><p>Санкт-Петербург</p><p>тел.: +79213469764</p></bio><bio xml:lang="en"><p>Natalya N. Kulaeva, Associate Professor, Candidate of Medical Sciences</p><p>Department of Internal Diseases</p><p>195067</p><p>Piskarevsky pr., 47</p><p>St. Petersburg</p><p>Phone: +79213469764</p></bio><email xlink:type="simple">kulaevanat@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Санкт-Петербургский государственный университет им. акад. И. П. Павлова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov Saint-Petersburg State University named after Academician I. P. Pavlova</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Санкт-Петербургский государственный университет; Первый Санкт-Петербургский государственный университет им. акад. И. П. Павлова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint-Petersburg State University; Pavlov Saint-Petersburg State University named after Academician I. P. Pavlova</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Северо-Западный государственный медицинский уни-&#13;
верситет им. И. И. Мечникова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Clinical Pharmacology and Neurology, I. I. Mechnikov Northwestern State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>07</day><month>03</month><year>2023</year></pub-date><volume>27</volume><issue>1</issue><fpage>78</fpage><lpage>85</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Коростелева Н.Ю., Румянцев А.Ш., Хасун М.Х., Лукичев Б.Г., Лебедева Э.Б., Григорян Е.В., Кулаева Н.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Коростелева Н.Ю., Румянцев А.Ш., Хасун М.Х., Лукичев Б.Г., Лебедева Э.Б., Григорян Е.В., Кулаева Н.Н.</copyright-holder><copyright-holder xml:lang="en">Korosteleva N.Y., Rumyantsev A.S., Khasun M.K., Lukichev B.G., Lebedeva E.B., Grigoryan E.V., Kulaeva N.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephrolog.ru/jour/article/view/2199">https://journal.nephrolog.ru/jour/article/view/2199</self-uri><abstract><sec><title>   ВВЕДЕНИЕ</title><p>   ВВЕДЕНИЕ. Оценку физической работоспособности пациентов обычно проводят по результатам теста с 6-минутной ходьбой, которые, в первую очередь, ассоциируют с сердечной или дыхательной недостаточности.</p></sec><sec><title>   ЦЕЛЬ</title><p>   ЦЕЛЬ: проанализировать результаты теста с 6-минутной ходьбой с клинико-лабораторными показателями у пациентов с ХБП 5д, включая критерии белково-энергетической недостаточности.</p></sec><sec><title>   ПАЦИЕНТЫ И МЕТОДЫ</title><p>   ПАЦИЕНТЫ И МЕТОДЫ. Обследованы 67 человек с ХБП С5Д, из них 42 мужчины и 25 женщин, средний возраст 49,0 ± 14,9 и 57,2 ± 15,5 лет соответственно, р = 0,036. Длительность ЗПТ у мужчин – 96,1 ± 80,3 мес, у женщин – 100,7 ± 66,1 мес, р = 0,810. Диагноз ишемической болезни сердца установлен у 22 человек, 7 из них перенесли ОИМ. Мышечную силу скелетной мускулатуры оценивали при помощи кистевого динамометра, работоспособность скелетной мускулатуры – при проведении теста с 6-минутной ходьбой. Все пациенты заполняли пищевые дневники, где указывали качественный и количественный состав потребляемой ими пищи в течение 3 дней.</p></sec><sec><title>   РЕЗУЛЬТАТЫ</title><p>   РЕЗУЛЬТАТЫ. Нагрузку ходьбой легче всего переносили пациенты без клинических проявлений ИБС. Между пациентами с и без ОИМ в анамнезе число баллов по шкале Борга было сопоставимо и достигало максимальных значений. Наиболее высокая концентрация С-реактивного белка и наиболее низкая концентрация альбумина сыворотки отмечалась у пациентов, перенесших ОИМ. Выявлены взаимосвязи между альбумином сыворотки с С-реактивным белком и результатами теста с 6-минутной ходьбой, а также между индексом массы миокарда левого желудочка с результатами теста с 6-минутной ходьбой.</p></sec><sec><title>   ЗАКЛЮЧЕНИЕ</title><p>   ЗАКЛЮЧЕНИЕ. Гипертрофия левого желудочка маскирует клинические признаки снижения физической работоспособности, но увеличивает риск сердечно-сосудистых осложнений. Результаты теста с 6-минутной ходьбой у пациентов с ИБС следует оценивать более детально. Необходимо проведение ряда исследований, которые позволили бы уточнить, как нужно изменять диетические рекомендации в зависимости от уровня системного воспаления при ХБП.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>   BACKGROUND</title><p>   BACKGROUND. Assessment of physical performance in patients is usually based on the results of the 6-minute walk test, which is primarily associated with heart or respiratory failure.</p></sec><sec><title>   THE AIM</title><p>   THE AIM: to analyze the results of the 6-minute walk test with clinical and laboratory parameters of patients with CKD 5D, including criteria for protein-energy malnutrition.</p></sec><sec><title>   PATIENTS AND METHODS</title><p>   PATIENTS AND METHODS. 67 people with CKD 5D were examined, including 42 men and 25 women, mean age 49.0 ± 14.9 and 57.2 ± 15.5 years, respectively, p = 0.036. The duration of RRT in men was 96.1 ± 80.3 months, in women 100.7 ± 66.1 months, p = 0.810. The diagnosis of coronary heart disease was established in 22 people, 7 of them had AMI. The muscle strength of the skeletal muscles was assessed using a hand dynamometer, the performance of the skeletal muscles – during a test with a 6-minute walk. All patients filled out food diaries, where they indicated the qualitative and quantitative composition of the food which they consumed for 3 days.</p></sec><sec><title>   RESULTS</title><p>   RESULTS. Walking load was most easily tolerated by patients without clinical manifestations of CAD. Between patients with and without AMI in history, the number of points on the Borg scale was comparable and reached the maximum values. The highest concentration of C-reactive protein and the lowest concentration of serum albumin were observed in patients who had had AMI. Relationships were found between serum albumin with C-reactive protein and the results of the 6-minute walk test, as well as between the mass index of the left ventricular myocardium with the results of the 6-minute walk test.</p></sec><sec><title>   CONCLUSION</title><p>   CONCLUSION. Left ventricular hypertrophy masks the clinical signs of reduced physical performance, but increases the risk of cardiovascular complications. The results of the 6-minute walk test in patients with CAD should be evaluated in more detail. A number of studies are needed to clarify how dietary recommendations should be modified depending on the level of systemic inflammation in CKD.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая болезнь почек</kwd><kwd>гемодиализ</kwd><kwd>белково-энергетическая недостаточность</kwd><kwd>гипертрофия левого желудочка</kwd><kwd>системное воспаление</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic kidney disease</kwd><kwd>hemodialysis</kwd><kwd>protein-energy deficiency</kwd><kwd>left ventricular hypertrophy</kwd><kwd>systemic inflammation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kirkman D. L., Bohmke N., Carbone S. et al. Exercise intolerance in kidney diseases: physiological contributors and therapeutic strategies. 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