nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.36485/1561-6274-2023-27-1-108-114nefr-2203Research ArticleПРОГРАММА НЕПРЕРЫВНОГО ПОСЛЕДИПЛОМНОГО ОБРАЗОВАНИЯ ПО НЕФРОЛОГИИPROGRAM ON CONTINUOUS POSTGRADUATE EDUCATION ON NEPHROLOGYПроблема фокально-сегментарного гломерулосклероза при первичном гломерулонефритеThe problem of focal-segmental glomerulosclerosis in primary glomerulonephritishttps://orcid.org/0000-0002-0942-0103МорозовС. Л.MorozovS. L.

Сергей Леонидович Морозов

Научно-исследовательский клинический институт педиатрии им. акад. Ю. Е. Вельтищева

педиатрический факультет

кафедра госпитальной педиатрии № 2

Москва

Sergey L. Morozov

Research Clinical Institute of Pediatrics named after acad. Yu. E. Veltishcheva

Faculty of Pediatrics

Department of Hospital Pediatrics No. 2

Moscow

mser@list.ruhttps://orcid.org/0000-0002-3050-7748ДлинВ. В.DlinV. V.

Владимир Викторович Длин

Научно-исследовательский клинический институт педиатрии им. акад. Ю. Е. Вельтищева

Москва

Vladimir V. Dlin

Research Clinical Institute of Pediatrics named after acad. Yu. E. Veltishcheva

Moscow

vdlin@pedklin.ruРоссийский национальный исследовательский медицинский университет имени Н. И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian Federation202308032023271108114Copyright © Морозов С.Л., Длин В.В., 20232023Морозов С.Л., Длин В.В.Morozov S.L., Dlin V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/2203

   Понятие фокально-сегментарного гломерулосклероза в клинической практике используется для описания как отдельного заболевания, так и для морфологической характеристики вторичного поражения почек. Наиболее часто фокальный сегментарный гломерулосклероз возникает в результате течения первичного гломерулонефрита и является причиной развития нефротического синдрома. Особенностью течения нефротического синдрома при фокальном сегментарном гломерулосклерозе является более длительный ответ на стероидную терапию или формирование зависимости / резистентности к глюкокортикостероидам. Несмотря на развитие научного прогресса, проблема фокального сегментарного гломерулосклероза при первичном гломерулонефрите остается по-прежнему актуальной. Понимание механизмов повреждения подоцитов, прогрессирования заболевания важно не только для фундаментальных исследований, но и для повседневной клинической практики.

   The concept of focal segmental glomerulosclerosis in clinical practice is used to describe both a separate disease and morphological characteristics of secondary kidney damage. Most often, focal segmental glomerulosclerosis occurs as a result of the course of primary glomerulonephritis and is the cause of the development of nephrotic syndrome. A feature of the course of nephrotic syndrome in focal segmental glomerulosclerosis is a longer response to steroid therapy, or the formation of dependence/resistance to glucocorticosteroids. Despite the development of scientific progress, the problem of focal segmental glomerulosclerosis in primary glomerulonephritis is still relevant. Understanding the mechanisms of podocyte damage and disease progression is important not only for basic research, but also for everyday clinical practice.

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The authors declare that there are no conflicts of interest present.