nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.36485/1561-6274-2023-27-2-29-38nefr-2214Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESНервная система и почки. Перекрестные механизмы взаимодействия в норме и при патологииNervous system and kidneys. Cross-mechanisms of interaction in normal and pathological conditionshttps://orcid.org/0000-0003-0632-6653ЮсуповФ. А.YusupovF. A.

Юсупов Фуркат Абдулахатович, Проф. д-р мед наук, зав. кафедрой

714000, , г. Ош, ул. Ленина, д. 331

Тел.: (+996) 557202071

Furkat А. Yusupov, Prof., MD, PhD, DMedSci, Head of the Department of the of, member of the Board of the Society of Specialists in Chronic Kidney Disease of Kyrgyzstan

714000, Osh, Lenin Street, 331

Tel.: (+996) 557202071

furcat_y@mail.ruhttps://orcid.org/0000-0002-4179-9205ЮлдашевА. А.YuldashevA. A.

Юлдашев Акмал Акбарович, Аспирант

714000, , г. Ош, ул. Ленина, д. 331

Тел.: (+996) 559062491

Akmal А. Yuldashev, Postgraduate student, MD

714000, Osh, Lenin Street, 331

Phone: (+996) 559062491

akmal.yuldashev.2017@list.ruКафедра неврологии, психиатрии и нейрохирургии медицинского факультета Ошский государственный университетаКыргызстанOsh State University Medical Faculty, Department of Neurology, Psychiatry and NeurosurgeryKyrgyzstan2023060620232722938Copyright © Юсупов Ф.А., Юлдашев А.А., 20232023Юсупов Ф.А., Юлдашев А.А.Yusupov F.A., Yuldashev A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/2214

В физиологических состояниях нервная система и почки взаимодействуют друг с другом для поддержания нормального гомеостаза. Однако патологические состояния, такие как гипертоническая болезнь, патология самой почки как острое, так и хроническое, нарушают это взаимодействие. При остром повреждении почек (ОПП) различной этиологии и хронической болезни почек (ХБП) поврежденные почки могут оказывать существенное влияние на функцию центральной нервной системы. ХБП является независимым фактором риска развития цереброваскулярных заболеваний и когнитивных нарушений, обусловленны многими факторами, включая задержку уремических токсинов и фосфатов, были предложены в качестве специфических для ХБП факторов, ответственных за структурные и функциональные церебральные изменения у пациентов с ХБП, тем не менее необходимы дополнительные исследования для определения точного патогенеза. Наш обзор посвящается взаимодействию почки и нервной системы в физиологических условиях и при патофизиологических состояниях, пытаемся подробно раскрыть механизмы дисфункции нервной системы при патологиях почек.

In physiological states, the nervous system and kidneys interact with each other to maintain normal homeostasis in the body. However, pathological conditions such as hypertension, pathology of the kidney itself, both acute and chronic, disrupt this interaction. In acute kidney injury (AKI of various etiologies) and chronic kidney disease (CKD), damaged kidneys can have a significant impact on the function of the central nervous system. CKD is an independent risk factor for the development of cerebrovascular diseases and cognitive impairment due to many factors, including the retention of uremic toxins and phosphates, have been proposed as CKD-specific factors responsible for structural and functional cerebral changes in patients with CKD, however, additional studies are needed to determine the exact pathogenesis. Our review is devoted to the interaction of the kidney and the nervous system in physiological conditions and pathophysiological conditions, we are trying to reveal in detail the mechanisms of dysfunction of the nervous system in kidney pathologies.

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The authors declare that there are no conflicts of interest present.