nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.36485/1561-6274-2023-27-2-39-46nefr-2215Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРоль мочевой кислоты в развитии воспаления при заболеваниях почекThe role of uric acid in the development of infl ammation in kidney diseasehttps://orcid.org/0000-0001-6863-6898КуницкаяН. А.KunitskayaN. A.

Куницкая Наталия Александровна, проф., д-р мед. наук

191015, Санкт-Петербург, Пискаревский пр., д. 47

Тел.: (812) 303-50-00

Natalia А. Kunitskaya, MD, PhD, DMedSci, Prof. 

191015, Saint Petersburg, Piskarevsky, 47

Tel.: (812) 303-50-00

scvssd@yandex.ruhttps://orcid.org/0000-0001-8754-2870АрьевА. Л.ArievA. L.

Арьев Александр Леонидович, д-р мед. наук, проф. 

 

191015, Санкт-Петербург, Пискаревский пр., д. 47

Тел.: (812) 303-50-00

Alexander L. Ariev, MD, PhD, DMedSci, Prof. 

191015, Saint Petersburg, Piskarevsky, 47

Tel.: (812) 303-50-00

alex.l.ariev@gmail.comhttps://orcid.org/0000-0003-2704-679XКулаеваН. Н.KulaevaN. N.

Кулаева Наталия Николаевна, канд. мед. наук, доц. 

191015, Санкт-Петербург, Пискаревский пр., д. 47

Тел.: (812) 303-50-00

Natalia N. Kulaeva, MD, PhD, Associate prof. 

191015, Saint Petersburg, Piskarevsky, 47

Tel.: (812) 303-50-00

kulaevanat@mail.ruСеверо-Западный государственный медицинский университет имени И.И. МечниковаРоссияI.I.Mechnikov North-Western State Medical UniversityRussian Federation2023070620232723946Copyright © Куницкая Н.А., Арьев А.Л., Кулаева Н.Н., 20232023Куницкая Н.А., Арьев А.Л., Кулаева Н.Н.Kunitskaya N.A., Ariev A.L., Kulaeva N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/2215

Бессимптомная гиперурикемия часто наблюдается у пациентов с заболеваниями почек. Значительное число эпидемиологических исследований свидетельствуют о том, что повышенный уровень мочевой кислоты играет причинную роль в развитии и прогрессировании заболеваний почек. Но является ли гиперурикемия просто результатом снижения почечной экскреции мочевой кислоты или способствует прогрессированию болезни почек, остается спорным вопросом. За последние два десятилетия многочисленные экспериментальные исследования расширили знания о биологическом воздействии мочевой кислоты за пределы ее роли в развитии подагры. В частности, мочевая кислота индуцирует активацию иммунной системы и влияет не только на клетки тканей почек, но и на эндотелиальные клетки.  Все это привело к представлению мочевой кислоты как потенциального и модифицирующего фактора риска болезни почек. В данном обзоре рассматривается влияние мочевой кислоты на иммунную систему и далее на почечную ткань  при воспалении. 

Asymptomatic hyperuricemia is frequently seen in patients with kidney disease. A significant number of epidemiological studies suggest that elevated uric acid levels play a causal role in the development and progression of kidney disease. But whether hyperuricemia is simply the result of reduced renal excretion of uric acid or contributes to the progression of renal disease remains controversial. Over the past two decades, numerous experimental studies have expanded the knowledge of the biological effects of uric acid beyond its role in the development of gout. In particular, uric acid induces activation of the immune system and affects not only renal tissue cells but also endothelial cells.  All this has led to the presentation of uric acid as a potential and modifying risk factor for kidney disease. This review examines the effects of uric acid on the immune system and further on renal tissue during inflammation.

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The authors declare that there are no conflicts of interest present.