nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.36485/1561-6274-2023-27-4-43-51RHVXHHnefr-2267Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРоль конечных продуктов гликирования в развитии саркопении у пациентов с ХБПThe role of advanced glycation end products in sarcopenia in CKD patientshttps://orcid.org/0000-0001-9895-7836БорискинаО. Л.BoriskinaO. L.

Старший специалист Борискина Ольга Леонидовна.

109028, Москва, Серебряническая наб., д. 29, офис 85. Тел.: +7-921-866-2006

Senior Clinical Research Associate Olga L. Boriskina.

109028, Moscow, 29, Serebryanicheskaya nab., offi ce 85. Phone: +7-921-866-2006

okhrushcheva@ya.ruhttps://orcid.org/0000-0003-1199-0911ЦыганВ. Н.TsiganV. N.

Профессор Цыган Василий Николаевич доктор медицинских наук, кафедра патологической физиологии, заведующий кафедрой, заслуженный деятель науки РФ.

194044, СанктПетербург, ул. Академика Лебедева, д. 6.

Prof. Vasiliy N. Tsigan - Honoured Scientist of the Russian Federation, Head of the Department of Pathological Physiology.

194044, St. Petersburg, 6, Akademika Lebedeva str.

vnt@mail.ruhttps://orcid.org/0000-0002-9455-1043РумянцевА. Ш.RumyantsevA. S.

Профессор Румянцев Александр Шаликович доктор медицинских наук, кафедра факультетской терапии Санкт-Петербургский ГУ; Пер вый Санкт-Петербургский ГМУ им. акад. И.П. Павлова, кафедра пропедевтики внутренних болезней.

199106, Санкт-Петербург, 21-я линия В.О., д. 8а. Тел.: +7 (812) 326-03-26. 197022;  Санкт-Петербург, ул. Льва Толстого, д. 6–8. Тел.: +7(911)2677413

Prof. Rumyantsev Aleksandr Shalikovich - MD, PhD, DMedSci  St. Petersburg SU, Department of faculty therapy, Pavlov University. Department of Propaedeutics of Internal Medicine.

199106, St. Petersburg, 21st line V.O., 8a., Phone: +7 (812) 326-03-26. 197022; L'va Tolstogo str. 6-8, Saint Petersburg. Phone: +7 (911) 2677413

rash.56@mail.ruhttps://orcid.org/0000-0003-1045-9336ЯковенкоА. А.YakovenkoA. A.

Доцент Яковенко Александр Александрович - кандидат медицинских наук, кафедра нефрологии и диализа ФПО.

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54. Тел.: 8(952)3625464

Jakovenko Alexandr A. - MD, PhD, Department of Nephrology and Dialysis of the Faculty of Postgraduate Education Propudeutics of Internal Diseases, associate professor.

197022, St-Petersburg, L. Tolstoy st., 17, build 54. Phone: 8(952)3625464

leptinrulit@mail.ruООО «АйКОН Клиникал Ресерч (Рус)»РоссияICON Clinical Research (Rus) LCCRussian FederationВоенно-медицинская академия имени С.М. Кирова Министерства обороны Российской ФедерацииРоссияMilitary Medical Academy named after S.M. KirovRussian FederationСанкт-Петербургский государственный университет; Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. ПавловаРоссияSaint-Petersburg State University; First Pavlov Saint-Petersburg State Medical UniversityRussian FederationПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П. ПавловаРоссияFirst Pavlov Saint-Petersburg State Medical UniversityRussian Federation2023021220232744351Copyright © Борискина О.Л., Цыган В.Н., Румянцев А.Ш., Яковенко А.А., 20232023Борискина О.Л., Цыган В.Н., Румянцев А.Ш., Яковенко А.А.Boriskina O.L., Tsigan V.N., Rumyantsev A.S., Yakovenko A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/2267

Накопление конечных продуктов гликирования (КПГ) тесно связано с хроническим воспалением, окислительным стрессом и может влиять на функцию мышц. Увеличение концентрации КПГ в сыворотке крови может наблюдаться у пациентов уже на начальных этапах формирования хронической болезни почек (ХБП). При этом нет необходимости в наличии нарушения толерантности к углеводам или сахарного диабета. Саркопения является одним из осложнений ХБП. Ее развитие при ХБП можно рассматривать, не только как результат эндогенной интоксикации, но и как один из вариантов преждевременного старения. Настоящий обзор литературы посвящен анализу механизмов влияния КПГ на возникновение и прогрессированию саркопении при ХБП.

The accumulation of glycation end products (AGEs) is closely related to chronic inflammation, oxidative stress and can affect muscle function. An increase of the concentration of AGEs in the serum can be observed in patients already at the initial stages of the formation of chronic kidney disease (CKD). At the same time, there is no need for a violation of carbohydrate tolerance or diabetes mellitus. Sarcopenia is one of the complications of CKD. Its development in CKD can be considered not only as a result of endogenous intoxication, but also as one of the variants of premature aging. This literature review is devoted to the analysis of the mechanisms of the influence of AGEs on the occurrence and progression of sarcopenia in CKD.

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The authors declare that there are no conflicts of interest present.