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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nefr</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology (Saint-Petersburg)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-6274</issn><issn pub-type="epub">2541-9439</issn><publisher><publisher-name>Pavlov First Saint-Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36485/1561-6274-2024-28-1-63-71</article-id><article-id custom-type="edn" pub-id-type="custom">SQQKCN</article-id><article-id custom-type="elpub" pub-id-type="custom">nefr-2291</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ. КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES. CLINICAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Госпитальные осложнения у больных с острым повреждением почек после операции коронарного шунтирования</article-title><trans-title-group xml:lang="en"><trans-title>Hospital complications in patients with acute kidney injury after coronary artery bypass grafting</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-5350-8426</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арутюнян</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Arutyunyan</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Арутюнян Люсине Амазасповна - доц. канд. мед. наук, кафедра кардиологии и кардиохирургии с курсом скорой медицинской помощи,</p><p>625023, г. Тюмень, ул. Одесская, д. 54</p></bio><bio xml:lang="en"><p>Lyusine А. Arutyunyan, Associate Professor, MD, PhD, Department of Cardiology and Cardiac Surgery With a Course of Emergency Medical Care,</p><p>625023, Tyumen, Odesskaya st., 54 build</p></bio><email xlink:type="simple">Lusnyak81@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6331-1218</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кремнева</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kremneva</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кремнева Людмила Викторовна - проф., д-р мед. наук, кафедра клинической лабораторной диагностики,</p><p>625037, г. Тюмень, ул. Белинского, д. 3, кв. 109</p><p>старший научный сотрудник научно-клинического отделения</p></bio><bio xml:lang="en"><p>Kremneva Lyudmila V. - Prof., MD, PhD, DMedSci, Department of Clinical Laboratory  Diagnostics, Professor of the Department, 625023, Tyumen, Odesskaya st., 54 build;</p><p>Scientific and Clinical Division, Tomsk</p></bio><email xlink:type="simple">KremnevaLV01@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1795-9595</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гапон</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gapon</surname><given-names>L. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гапон Людмила Ивановна, д-р мед. наук, засл. деят. науки РФ, руководитель научно-клинического отдела,</p><p>625026, г. Тюмень, ул. Мельникайте, д. 111</p></bio><bio xml:lang="en"><p>Gapon Lyudmila Ivanovna, Prof., MD, PhD, DMedSci, Honored Scientist of the Russian Federation, Head of the Scientifi c Division of Clinical Cardiology,</p><p>625026, Tyumen, Melnikayte st., 111 build</p></bio><email xlink:type="simple">Gapon@infarkta.net</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2724-4016</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шалаев</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shalaev</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шалаев Сергей Васильевич - проф., д-р мед. наук, зав. кафедрой кардиологии и кардиохирургии с курсом скорой медицинской помощи,</p><p>625023, г. Тюмень, ул. Одесская, д. 54</p></bio><bio xml:lang="en"><p>Shalaev Sergey Vasilyevich - Prof., MD, PhD, DMedSci, Departmentof Cardiology and Cardiac Surgery With a Course of Emergency Medical Care, Head of the Department,</p><p>625023, Tyumen, Odesskaya st., 54 build</p></bio><email xlink:type="simple">Shalaev@tokb.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тюменский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tyumen State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Тюменский государственный медицинский университет;&#13;
Тюменский кардиологический научный центр, Томский национальный  исследовательский медицинский центр Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tyumen State Medical University;&#13;
Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Тюменский кардиологический научный центр, Томский национальный исследовательский медицинский центр Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>04</day><month>03</month><year>2024</year></pub-date><volume>28</volume><issue>1</issue><fpage>63</fpage><lpage>71</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Арутюнян Л.А., Кремнева Л.В., Гапон Л.И., Шалаев С.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Арутюнян Л.А., Кремнева Л.В., Гапон Л.И., Шалаев С.В.</copyright-holder><copyright-holder xml:lang="en">Arutyunyan L.A., Kremneva L.V., Gapon L.I., Shalaev S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephrolog.ru/jour/article/view/2291">https://journal.nephrolog.ru/jour/article/view/2291</self-uri><abstract><p>Цель – оценка частоты госпитальных осложнений у больных с острым повреждением почек (ОПП) после операции коронарного шунтирования (КШ).</p><sec><title>Пациенты и методы</title><p>Пациенты и методы. В исследование включены 77 больных со стабильной стенокардией, перенесших КШ, в возрасте 65 (61–69) лет, мужчин – 77,9 %. Артериальную гипертензию имели 96,1 %, нарушения углеводного обмена – 45,5 %, хроническую болезнь почек (ХБП) – 22,1 %, перенесенный инфаркт миокарда (ИМ) – 57,1 % пациентов. КШ на работающем сердце выполнено у 28,6 %, в том числе бимаммарное КШ – у 49,4 % лиц. Длительность искусственного кровообращения составила 64 (55-82) мин, количество имплантированных шунтов – 2,7+0,7 ед. ХБП диагностировали при снижении скорости клубочковой фильтрации менее 60 мл/мин. Развитие ОПП оценивали в соответствии с критериями KDIGO (2012).</p></sec><sec><title>Результаты</title><p>Результаты. ОПП, связанное с КШ, выявлено у 10 (13 %) больных, из них 1 ст. – у 9 (11,7 %), 2 ст. – у 1 (1,3 %). Показателями, ассоциированными с ОПП после КШ, явились: более тяжелая ХБП (3б и 4 ст. – 20 % против 1,5 %, р=0,043), большая частота случаев острой сердечной недостаточности (по потребности в применении адреналина – 30 % против 5,9 %, р=0,043), большее число окклюзированных коронарных артерий (в группах с ОПП и без ОПП: одна окклюзия – 70 и 52,2 %, две – 0 и 13,4 %, три – 10 и 0 % соответственно, р=0,028). Более тяжелые стадии ХБП (3б и 4 ст.) статистически значимо повышали вероятность развития ОПП после КШ в среднем в 2,9 раза. Среди больных с ОПП по отношению к пациентам без ОПП после КШ была выше частота случаев сердечной смерти (20 % против 0 %, р=0,015), интраоперационного ИМ (60 % против 8,9 %, р=0,001), острой сердечной недостаточности (30 % против 5,9 %, р=0,043).</p></sec><sec><title>Заключение</title><p>Заключение. Частота ОПП после операции КШ составила 13%. Развитие ОПП ассоциировано с более тяжелыми стадиями ХБП. Больные с послеоперационным ОПП имеют неблагоприятный госпитальный прогноз.</p></sec></abstract><trans-abstract xml:lang="en"><p>The aim was to assess the incidence of hospital complications in patients with acute kidney injury (AKI) after coronary artery bypass grafting (CABG).</p><sec><title>Patients and Methods</title><p>Patients and Methods. The study included 77 patients with stable angina who underwent CABG, aged 65 (61-69) years, 77,9 % men. The number of patients with arterial hypertension was 96,1 %, with carbohydrate metabolism disorders 45,5 %, with chronic kidney disease (CKD) 22,1 %, and with myocardial infarction (MI) 57,1 %. CABG on the working heart was performed in 28,6 %, bimammary CABG in 49,4 %. The duration of artificial circulation was 64 (55-82) minutes; the number of shunts implanted was 2,7+0,7 units. CKD was diagnosed when the glomerular filtration rate was less than 60 ml/min. The development of AKI was assessed according to the KDIGO criteria (2012).</p></sec><sec><title>Results</title><p>Results. CABG related AKI was detected in 10 (13 %) patients, of which grade 1 in 9 (11,7 %), grade 2 in 1 (1,3 %). The indicators associated with AKI after CABG were more severe initial CKD (stages 3b and 4 CKD – 20 % vs 1,5 %, p=0,043), a higher incidence of acute heart failure (in terms of adrenaline requirement – 30 % vs 5,9 %, p=0,043), more occluded coronary arteries (in the groups with and without CABG: one occlusion 70 % and 52,2 %, two occlusions 0 % and 13,4 %, three occlusions 10 % and 0 %, respectively, p=0,028). More severe CKD (stages 3b and 4) statistically significantly increased the relative risk of AKI after CABG by an average of 2,9 times. Among patients with AKI compared to patients without AKI after CABG, there was a higher incidence of cardiac death (20 % vs 0 %, p=0,015), intraoperative MI (60 % vs 8,9 %, p=0,001), acute heart failure (30 % vs 5,9 %, p=0,043).</p></sec><sec><title>Conclusion</title><p>Conclusion. The incidence of AKI following CABG was 13 %. The development of AKI was associated with more severe initial CKD. Patients with postoperative AKI had a poor hospital prognosis.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>коронарное шунтирование</kwd><kwd>острое повреждение почек</kwd><kwd>госпитальные осложнения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronary artery bypass grafting</kwd><kwd>acute kidney injury</kwd><kwd>hospital complications</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Karkouti K, Wijeysundera DH, Yau TM et al. 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