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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nefr</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology (Saint-Petersburg)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-6274</issn><issn pub-type="epub">2541-9439</issn><publisher><publisher-name>Pavlov First Saint-Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">nefr-23</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Клинико-патогенетические аспекты повреждения почек при ожирении (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and paphogenical aspects of kidney damage in obesity (review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вялкова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vyalkova</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">k_pediatry@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедева</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedeva</surname><given-names>E. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Красиков</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasikov</surname><given-names>S. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зорин</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zorin</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулагина</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulagina</surname><given-names>E. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаева</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaeva</surname><given-names>S. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Государственное бюджетное образовательное учреждение высшего профессионального образования «Оренбургская государственная медицинская академия» Министерства здравоохранения Российской Федерации</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>01</day><month>05</month><year>2014</year></pub-date><volume>18</volume><issue>3</issue><fpage>24</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Вялкова А.А., Лебедева Е.Н., Красиков С.И., Зорин И.В., Кулагина Е.П., Николаева С.Н., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Вялкова А.А., Лебедева Е.Н., Красиков С.И., Зорин И.В., Кулагина Е.П., Николаева С.Н.</copyright-holder><copyright-holder xml:lang="en">Vyalkova A.A., Lebedeva E.N., Krasikov S.I., Zorin I.V., Kulagina E.P., Nikolaeva S.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephrolog.ru/jour/article/view/23">https://journal.nephrolog.ru/jour/article/view/23</self-uri><abstract><p>Ожирение является одной из актуальных медико-социальных проблем современного общества. Быстрый рост числа лиц, страдающих избыточной массой тела, определяет актуальность этой проблемы. Ожирение приводит к прогрессивному повреждению почек через множество механизмов. Использование ранних биомаркеров патологии почек при ожирении с оценкой уровня показателей липидного, углеводного обмена, инсулинорезистентности, сывороточного лептина и адипонектина является перспективным для диагностики ренального поражения при ожирении у детей.</p></abstract><trans-abstract xml:lang="en"><p>Obesity is one of actual medico-social problems of modern society. Rapid growth of the persons suffering from excess mass of a body, defines relevance of this problem. Obesity leads to progressive injury of kidneys through a set of mechanisms. Use of early biomarkers of pathology of kidneys at obesity with an assessment of level of indicators of a lipid, carbohydrate exchange, insulin resistance, serum leptin and adiponectin are perspective for diagnostics of renal defeat at obesity in children.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ожирение</kwd><kwd>почки</kwd><kwd>лептин</kwd><kwd>адипонектин</kwd><kwd>фактор некроза опухоли-альфа</kwd><kwd>ренин-ангиотензиновая система</kwd><kwd>внутриклубочковая гипертензия</kwd><kwd>подоцит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>obesity</kwd><kwd>kidney</kwd><kwd>leptin</kwd><kwd>adiponectin</kwd><kwd>tumor necrosis factor - alpha</kwd><kwd>renin-angiotensin system</kwd><kwd>interaglomerulus hypertension</kwd><kwd>podocyte</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бутрова СА, Дзгоева ФХ. 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