nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical Universitynefr-233Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESМЕХАНИЗМЫ ОТТОРЖЕНИЯ ПОЧЕЧНОГО АЛЛОТРАНСПЛАНТАТА И ИММУНОЛОГИЧЕСКАЯ ТОЛЕРАНТНОСТЬRENAL ALLOGRAFT REJECTION MECHANISMS AND IMMUNOTOLERANCEВатазинА. В.VatazinA. V.

Ватазин Андрей Владимирович, доктор медицинских наук, профессор. 

Руководитель отдела трансплантологии, нефрологии и хирургической гемокоррекции. 

129110, Москва, ул. Щепкина, д. 61/2, корп. 6.

Andrey V. Vatazin, MD, PhD, Professor of medicine, DMedSci. 

Head of the Department of Transplantation, Nephrology and Surgical hemocorrection. 

Adress: 129110, Moscow, Shchepkin Str., 61/2, building 6. 

vatazin@yandex.ruКильдюшевскийА. В.Kildjushevskiy,A. V.

Кильдюшевский Александр Вадимович, доктор медицинских наук, профессор.

Ведущий научный сотрудник отделения хирургической гемокоррекции и детоксикации.

129110, Россия, Москва, ул. Щепкина, д. 61/2, корп. 11.

Alexander V. Kildushevskiy, Prof, MD, PhD, DMedSci.

Leading researcher of the department of Surgical hemocorrection and detoxifi cation.

Adress: 129110 Russia, Moscow, Shchepkina st., 61/2, build. 11.

kildushev@yandex.ruФедулкинаВ. А.FedulkinaV. A.

Федулкина Вероника Андреевна, кандидат медицинских наук.

Старший научный сотрудник хирургического отделения трансплантологии и диализа.

129110, Россия, Москва, ул. Щепкина, д. 61/2, корп. 6

Veronica A. Fedulkina MD, PhD,

Senior Researcher of the Surgical department of Transplantation and Dialysis. 

Adress: 129110 Russia, Moscow, Shchepkina st., 61/2, build. 6. 

v.fedulkina@mail.ruФаенкоА. ПFaenkoA. P.

Фаенко Александр Павлович - Старший лаборант курса клинической трансфузиологии. 

129110, Россия, Москва, ул. Щепкина, д. 61/2, корп. 8. 

Alexander P. Faenko, Senior Assistant of the Department of Clinical Transfusion.

Adress: 129110 Russia, Moscow, Shchepkina st., 61/2, build. 8. 

alexfaenko@mail.ruМосковский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоРоссияMoscow regional research and clinical institute named after M.F. VladimirskyRussian Federation2016030320172063341Copyright © Ватазин А.В., Кильдюшевский А.В., Федулкина В.А., Фаенко А.П., 20172017Ватазин А.В., Кильдюшевский А.В., Федулкина В.А., Фаенко А.П.Vatazin A.V., Kildjushevskiy, A.V., Fedulkina V.A., Faenko A.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/233

В статье отражены основные причины и механизмы развития отторжения почечного аллотрансплантата, описаны современные представления о формировании иммунологической толерантности.

The review summarizes basic causes and mechanisms of renal allograft rejection, describes the modern concept of immune tolerance formation.

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The authors declare that there are no conflicts of interest present.