nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.36485/1561-6274-2025-29-2-9-16FQWGFCnefr-2414Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESГиперурикемия и нефро-церебральный континуумHyperuricemia and the nephrocerebral continuumhttps://orcid.org/0000-0003-0632-6653ЮсуповФ. А.YusupovF. A.

Проф. Юсупов Фуркат Абдулахатович - д-р мед. наук. Кафедра неврологии, психиатрии и нейрохирургии медицинского факультета Ошского государственного университета. Зав. каф., член правления Общества специалистов по хронической болезни почек Кыргызстана.

714000, Ош, ул. Ленина, д. 331. Тел.: (+996) 557202071

Yusupov Furkat Abdulakhatovich - MD, Professor, Head of the Department of Neurology, Psychiatry and Neurosurgery of the Medical Faculty of Osh State University, member of the Board of the Society of Specialists in Chronic Kidney Disease of Kyrgyzstan.

331 Lenin Street, Osh, 714000. Tel.: (+996) 557202071

furcat_y@mail.ruhttps://orcid.org/0000-0003-4839-1306ЫдырысовИ. Т.YdyrysovI. T.

Проф. Ыдырысов Исматилла Токтосунович - д-р мед. наук. Ошский государственный университет, декан медицинского факультета.

714000, Ош, ул. Ленина, д. 331. Тел.: (+996) 772334433

Ydyrysov Ismatilla Toktosunovich - Doctor of Medical Sciences; Professor; Dean of the Faculty of Medicine. Osh State University.

331 Lenin Street, Osh, 714000. Tel.: (+996) 772334433

zinur11@mail.ruhttps://orcid.org/0000-0002-4179-9205ЮлдашевА. А.YuldashevA. A.

Юлдашев Акмал Акбарович - Кафедра неврологии, психиатрии и нейрохирургии медицинского факультета Ошского государственного университета, аспирант.

714000, Ош, ул. Ленина, д. 331. Тел.: (+996) 559062491

Yuldashev Akmal Akbarovich - postgraduate student of the Department of Neurology, Psychiatry and Neurosurgery of the Medical Faculty of Osh State University.

331 Lenin Street, Osh, 714000. Tel.: (+996) 559062491

akmal.yuldashev.2017@list.ruОшский государственный университетКыргызстанOsh State UniversityKyrgyzstan202504062025292916Copyright © Юсупов Ф.А., Ыдырысов И.Т., Юлдашев А.А., 20252025Юсупов Ф.А., Ыдырысов И.Т., Юлдашев А.А.Yusupov F.A., Ydyrysov I.T., Yuldashev A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/2414

Мочевая кислота играет важную роль в развитии заболеваний почек и цереброваскулярных заболеваний. Почки играют решающую роль в регулировании уровня мочевой кислоты в сыворотке крови, на их долю приходится 60–70 % экскреции мочевой кислоты. В норме почки реабсорбируют примерно 90 % мочевой кислоты, отфильтрованной клубочками в проксимальных канальцах. Мочевая кислота является продуктом распада пуринов и может выполнять множество физиологических функций, включая антиоксидантные и нейропротекторные, поддержание кровяного давления при приеме с низким содержанием соли и модуляцию иммунитета. Однако избыточная продукция мочевой кислоты и/или дисбаланс почечной секреции и реабсорбции мочевой кислоты, и/или недостаточная экскреция внепочечной мочевой кислоты, например, в кишечнике, будут способствовать гиперурикемии, которая является распространенным метаболическим заболеванием. Гиперурикемия и подагра связаны с многочисленными сердечно-сосудистыми и почечными нарушениями, например, гипертонией, инфарктом миокарда, инсультом, ожирением, гиперлипидемией, сахарным диабетом 2 типа и хроническими заболеваниями почек. В статье обсуждается нефро-церебральный континуум при гиперурикемии.

Uric acid plays an important role in the development of kidney disease and cerebrovascular diseases. The kidneys play a crucial role in regulating serum uric acid levels, accounting for 60-70 % of uric acid excretion. Normally, the kidneys reabsorb about 90 % of the uric acid filtered by the glomeruli in the proximal tubules. Uric acid is a product of the breakdown of purines and can perform many physiological functions, including antioxidant and neuroprotective, maintaining blood pressure when taken with a low salt content and modulating immunity. However, excessive production of uric acid and/or an imbalance of renal secretion and reabsorption of uric acid and/or insufficient excretion of extrarenal uric acid, for example, in the intestine, will contribute to hyperuricemia, which is a common metabolic disease. Hyperuricemia and gout are associated with numerous cardiovascular and renal disorders, such as hypertension, myocardial infarction, stroke, obesity, hyperlipidemia, type 2 diabetes mellitus and chronic kidney disease. The article discusses the nephrocerebral continuum in hyperuricemia.

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The authors declare that there are no conflicts of interest present.