nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical Universitynefr-242Research ArticleПРОГРАММА НЕПРЕРЫВНОГО ПОСЛЕДИПЛОМНОГО ОБРАЗОВАНИЯ ПО НЕФРОЛОГИИPROGRAM ON CONTINUOUS POSTGRADUATE EDUCATION ON NEPHROLOGYТРАНСПЛАНТАЦИЯ ПОЧКИ У ПАЦИЕНТОВ С АТИПИЧНЫМ ГЕМОЛИТИКО-УРЕМИЧЕСКИМ СИНДРОМОМ (лекция)KIDNEY TRANSPLANTATION IN PATIENTS WITH ATYPICAL HAEMOLYTIC URAEMIC SYNDROME (lection)ПрокопенкоЕ. И.ProkopenkoE. I.

Прокопенко Елена Ивановна, доктор медицинских наук.

Факультет усовершенствования врачей, кафедра трансплантологии, нефрологии и искусственных органов. 

129110, Россия, Москва, ул. Щепкина, д. 61/2. 

Elena I. Prokopenko MD PhD.

Postgraduate Medical Faculty, Department of transplantology, nephrology and artificial organs. 

129110 Russia, Moscow, Shchepkin st., 61/2.

renalnephron@gmail.comВатазинА. В.VatazinA. V.

Ватазин Андрей Владимирович, доктор медицинских наук, профессор. 

Руководитель отдела трансплантологии, нефрологии и хирургической гемокоррекции. 

129110, Москва, ул. Щепкина, д. 61/2, корп. 6.

Andrey V. Vatazin, MD, PhD, Professor of medicine, DMedSci. 

Postgraduate Medical Faculty, Department of transplantology, nephrology and artificial organs. 

129110, Moscow, Shchepkin Str., 61/2, building 6. 

vatazin@yandex.ruЩербаковаЕ. О.ShcherbakovaE. O.

Щербакова Евгения Оттовна, кандидат медицинских наук.

Факультет усовершенствования врачей, кафедра трансплантологии, нефрологии и искусственных органов. 

129110, Россия, Москва, ул. Щепкина, д. 61/2. 

Evgenia O. Shcherbakova MD. 

Postgraduate Medical Faculty, Department of transplantology, nephrology and artificial organs. 

129110 Russia, Moscow, Shchepkin st., 61/2.

Московский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоРоссияMoscow regional research and clinical institute named after M.F. VladimirskyRussian Federation201603032017206111118Copyright © Прокопенко Е.И., Ватазин А.В., Щербакова Е.О., 20172017Прокопенко Е.И., Ватазин А.В., Щербакова Е.О.Prokopenko E.I., Vatazin A.V., Shcherbakova E.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/242

Трансплантация почки (ТП) до недавнего времени считалась противопоказанной пациентам с терминальной почечной недостаточностью в исходе атипичного гемолитико-уремического синдрома (аГУС) из-за высокого риска рецидива основного заболевания и потери трансплантата. Однако в настоящее время разработаны новые подходы к профилактике и лечению рецидива аГУС в посттрансплантационном периоде, что способствовало значительному улучшению результатов ТП у этой категории больных. В статье рассматриваются принципы оценки риска рецидива аГУС после ТП, подбора органного донора, особенности иммуносупрессивной терапии, профилактики и лечения эпизодов аГУС у реципиентов ренального трансплантата.

Kidney transplantation (KT) until recent time was considered contraindicated to patients with end stage kidney failure due to atypical hemolytic uremic syndrome (aHUS) because of high risk of recurrence of the underlying disease and graft loss. However, it has now developed new approaches to prevention and treatment aHUS relapse in posttransplantation period, which significantly improved KT results in these patients. This article discusses the principles of risk assessment aHUS relapse after transplantation, the donor organ selection, features of immunosuppressive therapy, prevention and treatment of aHUS episodes in renal transplant recipients.

 

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The authors declare that there are no conflicts of interest present.