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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nefr</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology (Saint-Petersburg)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-6274</issn><issn pub-type="epub">2541-9439</issn><publisher><publisher-name>Pavlov First Saint-Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.36485/1561-6274-2026-30-1-112-116</article-id><article-id custom-type="edn" pub-id-type="custom">FCPVKI</article-id><article-id custom-type="elpub" pub-id-type="custom">nefr-2529</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАБЛЮДЕНИЯ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICAL NOTES</subject></subj-group></article-categories><title-group><article-title>Клинический случай метаболической нефропатии с выраженной протеинурией</article-title><trans-title-group xml:lang="en"><trans-title>A clinical case of metabolic nephropathy with severe proteinuria</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6597-3872</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рогозина</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rogozina</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доц. Рогозина Лариса Александровна, канд. мед. наук, кафедра госпитальной терапии с курсами гематологии и трансфузиологии</p><p>443099, г. Самара, ул. Чапаевская, д. 89</p><p>Тел.: 89276574162</p></bio><bio xml:lang="en"><p>Аssociate professor Rogozina Larisa Aleksandrovna, PhD,  Department of Hospital Therapy with courses in Hematology and Transfusiology</p><p>443099, Samara, Chapaevskaia st, 89</p><p>Phone: 89276574162</p></bio><email xlink:type="simple">rlarisa708@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6946-6816</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воробьева</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vorobyeva</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воробьева Ольга Алексеевна, канд. мед. наук, заведующая отделением патологии почек и диагностики сложных морфологических заболеваний</p><p>192071, Санкт-Петербург, пр. Славы, д. 32, литер А</p><p>Тел.: 89219927245</p></bio><bio xml:lang="en"><p>Vorobyeva Olga Alekseevna, MD, PhD, Head of the Department of Kidney Pathology and Diffi cult Morphological Diagnosis</p><p>192071, Saint Petersburg, Slavy Avenue, 32</p><p>Phone: +7(812)679-42-50</p></bio><email xlink:type="simple">olvorob70@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9525-0058</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гергель</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gergel</surname><given-names>Iu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доц. Гергель Юлия Анатольевна, канд. мед. наук, кафедра госпитальной терапии с курсами гематологии и трансфузиологии</p><p>443099, г. Самара, ул. Чапаевская, д. 89</p><p>Тел.: 8(927)730-86-14</p></bio><bio xml:lang="en"><p>Аssociate professor Gergel Iulia Anatolevna, MD, PhD, Department of Hospital Therapy with courses in Hematology and Transfusiology</p><p>443099, Samara, Chapaevskaia st, 89</p><p>Phone: 8(927)730-86-14</p></bio><email xlink:type="simple">Kossyyy1@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ничик</surname><given-names>Т. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Nichik</surname><given-names>T. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ничик Татьяна Евгеньевна, заведующая отделением нефрологии</p><p>443095, г. Самара, ул. Ташкентская д. 159</p><p>Тел.: 89278910029</p></bio><bio xml:lang="en"><p>Nichik Tatiana Evgenievna MD, Department of Nephrology</p><p>443095 Samara, Tashkent Street 159</p><p>Phone: 89278910029</p></bio><email xlink:type="simple">nichik66@inbox.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0645-7645</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давыдкин</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Davydkin</surname><given-names>I. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Проф. Давыдкин Игорь Леонидович, д-р мед. наук, кафедра госпитальной терапии с курсами гематологии и трансфузиологии, заведующий кафедрой</p><p>443099, г. Самара, ул. Чапаевская, д. 89</p><p>Тел.: 8 (846)3741001</p></bio><bio xml:lang="en"><p>Professor Igor Leonidovich Davydkin, MD, PhD, DMedSci, Department of Hospital Therapy with courses in Hematology and Transfusiology</p><p>443099, Samara, Chapaevskaia st, 89</p><p>Phone: 8 (846)3741001</p></bio><email xlink:type="simple">i.l.davydkin@samsmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Самарский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ООО «Национальный Центр Клинической Морфологической Диагностики»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Center of Clinical Morphological Diagnostics</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Самарская областная клиническая больница им В.Д.Середавина</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara Regional Clinical Hospital named after V.D.Seredavin</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>09</day><month>03</month><year>2026</year></pub-date><volume>30</volume><issue>1</issue><fpage>112</fpage><lpage>116</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Рогозина Л.А., Воробьева О.А., Гергель Ю.А., Ничик Т.Е., Давыдкин И.Л., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Рогозина Л.А., Воробьева О.А., Гергель Ю.А., Ничик Т.Е., Давыдкин И.Л.</copyright-holder><copyright-holder xml:lang="en">Rogozina L.A., Vorobyeva O.A., Gergel I.A., Nichik T.E., Davydkin I.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephrolog.ru/jour/article/view/2529">https://journal.nephrolog.ru/jour/article/view/2529</self-uri><abstract><p>В современном мире распространенность хронической болезни почек (ХБП) приближается к уровню эпидемии. Для некоторых фенотипов ХБП вторичной этиологии характерно медленное прогрессирование с длительным периодом малосимптомного течения, когда величина протеинурии не достигает нефротического уровня. Оценка прогностических маркеров на ранних стадиях ХБП необходима для снижения рисков прогрессии дисфункции почек и сердечнососудистых заболеваний путем своевременной патогенетической коррекции, на что следует обращать внимание не только врачам нефрологам, но и представителям других специальностей первичного звена здравоохранения. В статье описан пациент-мужчина, 64 лет, с ожирением, эпизодами гипергликемии, длительно страдающий артериальной гипертензией. Результаты биохимических анализов подтверждают наличие гипергликемии, гиперурикемии, дислипидемии. Морфологические исследования указывают на развитие вторичного сегментарного гломерулосклероза, в том числе, и в зоне сосудистого полюса клубочков. Аутоиммунная патология исключена. В анализах мочи отмечаются эпизоды протеинурии до 4,2 г/сут. После адекватной коррекции терапии артериальной гипертензии, дислипидемии, гипергликемии, гиперурикемии отмечено снижение протеинурии. Обследование и лечение таких пациентов требует комплексного подхода с обязательным участием нефрологов и эндокринологов.</p></abstract><trans-abstract xml:lang="en"><p>Globally, the prevalence of chronic kidney disease (CKD) is approaching epidemic levels. Some CKD phenotypes of secondary etiology are characterized by slow progression with a prolonged period of asymptomatic progression, does not reach nephrotic levels. Assessing prognostic markers in the early stages of CKD is essential to reduce the risk of progression to kidney dysfunction and cardiovascular disease through timely pathogenetic correction. This should be addressed not only by nephrologists but also by other primary care practitioners. This article describes a 64-year-old male patient with obesity, episodes of hyperglycemia, and long-standing arterial hypertension. Biochemical analysis confirms hyperglycemia, hyperuricemia, and dyslipidemia. Morphological studies indicate the development of secondary segmental glomerulosclerosis, including in the vascular pole of the glomeruli. Autoimmune pathology has been excluded. Urinalysis revealed episodes of proteinuria up to 4.2 g per day. After adequate treatment of hypertension, dyslipidemia, hyperglycemia, and hyperuricemia, a decrease in proteinuria was observed. The evaluation and treatment of these patients requires a comprehensive approach, with the mandatory participation of nephrologists and endocrinologists.when proteinuria</p></trans-abstract><kwd-group xml:lang="ru"><kwd>протеинурия</kwd><kwd>хроническая болезнь почек</kwd><kwd>артериальная гипертензия</kwd><kwd>дислипидемия</kwd><kwd>гиперурикемия</kwd><kwd>гипергликемия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>proteinuria</kwd><kwd>chronic kidney disease</kwd><kwd>hypertension</kwd><kwd>dyslipidemia</kwd><kwd>hyperuricemia</kwd><kwd>hyperglycemia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Jiang Z, Wang Y, Zhao X et al. Obesity and chronic kidney disease. Am J Physiol Endocrinol Metab 2023 Jan 1;324(1):E24– E41. doi: 10.1152/ajpendo.00179.2022. Epub 2022 Nov 16. PMID: 36383637</mixed-citation><mixed-citation xml:lang="en">Jiang Z, Wang Y, Zhao X et al. 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