nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2017-21-2-56-61nefr-254Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИ. КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯORIGINAL ARTICLES. CLINICAL INVESTIGATIONSИМЕЮТСЯ ЛИ АССОЦИАЦИИ ОЖИРЕНИЯ С ПРОГРЕССИРОВАНИЕМ СТЕРОИД-РЕЗИСТЕНТНОГО НЕФРОТИЧЕСКОГО СИНДРОМА У ДЕТЕЙ?IS OBESITY ASSOCIATED WITH PROGRESSION OF STEROID-RESISTANT NEPHROTIC SYNDROME IN CHILDREN?ПриходинаЛ. С.PrikhodinaL. S.

Профессор Приходина Лариса Серафимовна, доктор медицинских наук 

Отдел наследственных и приобретенных болезней почек, научно-исследовательского клинического института педиатрии им. акад. Ю.Е. Вельтищева.

125412, Москва, ул. Талдомская, д. 2.

Prof. Larisa S. Prikhodina, MD, PhD. 

Division of Inherited and Acquired Kidney Diseases, Research Clinical Institute for Pediatrics n.a. acad. Y.E. Veltishev. 

125412 Moscow, Taldomskaya St., 2.

prikhodina@rambler.ruПапижС. В.PapizhS. V.

Папиж Светлана Валентиновна, кандидат медицинских наук 

Отдел наследственных и приобретенных болезней почек, научно-исследовательского клинического института педиатрии им. акад. Ю.Е. Вельтищева.

125412, Москва, ул. Талдомская, д. 2.

Svetlana V. Papizh, MD, PhD. 

Division of Inherited and Acquired Kidney Diseases, Research Clinical Institute for Pediatrics n.a. acad. Y.E. Veltishev. 

125412 Moscow, Taldomskaya St., 2.

papijsveta@mail.ruЛебеденковаМ. В.LebedenkovaM. V.

Лебеденкова Марина Васильевна 

Отдел наследственных и приобретенных болезней почек, научно-исследовательского клинического института педиатрии им. акад. Ю.Е. Вельтищева.

125412, Москва, ул. Талдомская, д. 2.

Marina V. Lebedenkova, MD. 

Division of Inherited and Acquired Kidney Diseases, Research Clinical Institute for Pediatrics n.a. acad. Y.E. Veltishev.

125412 Moscow, Taldomskaya St., 2.

lebedenkova@mail.ruСтоляревичЕ. С.StolyarevichE. S.

Столяревич Екатерина Сергеевна, доктор медицинских наук 

123182, Москва, ул. Пехотная, д. 3.

Ekaterina S. Stolyarevich, MD, DMedSci. 

123182 Moscow, Shchukinskaya Str., d. 1

stolyarevich@yandex.ruРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова; Российская медицинская академия непрерывного профессионального образованияРоссияPirogov Russian National Research Medical University; Medical Continuous Postgraduate EducationRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian FederationФедеральный научный центр трансплантологии и искусственных органов им. акад. В.И. Шумакова; Московский медико-стоматологический университет; Городская клиническая больница №52 Департамента здравоохранения г. МосквыРоссияAcademician V.I. Shumakov Federal Research Center of Transplantology and Artificial Organs; Moscow University of Medicine and Dentistry; City Clinical Hospital №52 Department of Health in Moscow, Moscow City Nephrology CenterRussian Federation2017030320172125661Copyright © Приходина Л.С., Папиж С.В., Лебеденкова М.В., Столяревич Е.С., 20172017Приходина Л.С., Папиж С.В., Лебеденкова М.В., Столяревич Е.С.Prikhodina L.S., Papizh S.V., Lebedenkova M.V., Stolyarevich E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/254

ЦЕЛЬ: исследование потенциальных ассоциаций ожирения с прогрессирующим течением идиопатического стероидрезистентного нефротического синдрома(СРНС) у детей. ПАЦИЕНТЫ И МЕТОДЫ. Проведено 15-летнее одноцентровое ретроспективное исследование течения СРНС у 65 детей, разделенных на 2 группы:1) с ожирением (n=48); 2) с нормальной и избыточной массой тела (n=17). РЕЗУЛЬТАТЫ. У пациентов со СРНС и ожирением не установлено взаимосвязей с клиническими предикторами неблагоприятного почечного исхода – артериальной гипертензией и протеинурией, а также со скоростью клубочковой фильтрации при последней госпитализации. Почечная выживаемость у детей со СРНС и ожирением была сопоставима с группой пациентов с нормальной и избыточной массой тела. ЗАКЛЮЧЕНИЕ. Ожирение не влияет на течение и прогноз СРНС у детей и не может рассматриваться в качестве фактора риска прогрессирования заболевания. 

THE AIM: to study potential associations of obesity with progression of idiopathic steroid-resistant nephrotic syndrome (SRNS) in children. PATIENTS AND METHODS. We performed a retrospective one-center 15-years follow up study of SRNS course in 65 children divided into 2 groups: 1) with obesity (n=48); 2) with normal weight or overweight (n=17). RESULTS. In patients with SRNS and obesity we found no associations with clinical predictors of unfavorable outcome – arterial hypertension and proteinuria and also with glomerular filtration rate at recent hospitalization. Renal survival was comparable between SRNS patients with obesity and normal weight or overweight. CONCLUSION. Obesity does not have any impact on course and prognosis of SRNS in children and can not be considered as risk factor for the disease progression.

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The authors declare that there are no conflicts of interest present.