nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2017-21-4-30-39nefr-276Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESЭКТОПИЧЕСКАЯ КАЛЬЦИФИКАЦИЯ ПРИ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕК. ЧАСТЬ 1. КЛАССИФИКАЦИЯ И ПАТОГЕНЕЗECTOPIC CALCIFICATION IN CHRONIC KIDNEY DISEASE. PART 1. CLASSIFICATION AND PATHOGENESISЕгшатянЛ. В.EgshatyanL. V.

канд. мед. наук

Кафедра эндокринологии и диабетологии

MD, PhD

lilit.egshatyan@yandex.ruМокрышеваН. Г.MokryshevaN. G.

д-р мед. наук

MD, PhD

nm70@mail.ruЦентр патологии околощитовидных желез Эндокринологического научного центра МЗ РФ; ГБОУ ВПО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова»РоссияFederal State Budgetary Establishment Endocrinology Research Centre, Ministry of Health of Russia, Department «pathology of the parathyroid glands»; Chair of Endocrinology and Diabetology, A.I. Evdokimov Moscow State University of Medicine and DentistryRussian FederationЦентр патологии околощитовидных желез Эндокринологического научного центра МЗ РФРоссияFederal State Budgetary Establishment Endocrinology Research Centre, Ministry of Health of Russia, Department «pathology of the parathyroid glands»Russian Federation2017050720172143039Copyright © Егшатян Л.В., Мокрышева Н.Г., 20172017Егшатян Л.В., Мокрышева Н.Г.Egshatyan L.V., Mokrysheva N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/276

Сердечно-сосудистые заболевания являются ведущей причиной смерти пациентов с хронической болезнью почек. Прогностическим предиктором этих осложнений является эктопическая/сосудистая кальцификация. Кальцификация мягких тканей и сосудов при уремии является результатом минеральных и костных нарушений; терапии, направленной на их коррекцию; трансдифференцировки сосудистых гладкомышечных клеток. В статье представлен обзор литературы, обобщающий данные о механизмах развития и патогенез эктопической кальциф икации при хронической болезни почек.

Cardio-vascular diseases are the main cause of death in patietns with chronic kidney disease. Prognostic predictor of these complications if ectopic/vascular calcification. Calcification of soft tissues and vessels in uremia is the result of mineral and bone disorders; therapy for its correction; transdifferentiation of vascular smooth muscle cells. This article presents the literature review which summarizes data of mechanisms and pathogenesis of ectopic calcification in chronic kidney disease.

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The authors declare that there are no conflicts of interest present.