nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2017-21-5-119-124nefr-303Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИ (ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ)ДИНАМИКА МОРФОЛОГИЧЕСКИХ АДАПТАЦИОННО- КОМПЕНСАТОРНЫХ ИЗМЕНЕНИЙ В ТКАНИ КОНТРАЛАТЕРАЛЬНОЙ ПОЧКИ ПРИ ОБСТРУКЦИИ МОЧЕТОЧНИКОВ В ЭКСПЕРИМЕНТЕMORPHOLOGICAL ADAPTATION-COMPENSATORY CHANGES DYNAMICS IN CONTRALATERAL KIDNEY DURING URETERAL OBSTRUCTION IN THE EXPERIMENTАкименкоМ. А.AkimenkoM. A.

кафедра медицинской биологии и генетики,

344022, г. Ростов-на-Дону, Нахичеванский пер., д. 29

Department of Medical Biology and Genetics,

344022, Rostov-on-Don, Nahichevansky av., 29

akimenkoma@yandex.ruТодоровС. С.TodorovS. S.

д-р мед. наук, руководитель морфологического отдела и отдела молекулярно- биологических и оптических методов исследования, 

344022, г. Ростов-на-Дону, Нахичеванский пер., д. 29

M.D., PhD, DMedSci, head of the morphological department and department of molecular biological and optical methods of research,

344022, Rostov-on-Don, Nahichevansky av., 29

sertodorov@gmail.comКолмаковаТ. С.KolmakovaT. S.

д-р биол. наук, кафедра медицинской биологии и генетики,

344022, г. Ростов-на-Дону, Нахичеванский пер., д. 29

Assosiate professor, PhD, DBiolSci, Department of Medical Biology and Genetics, head, 

344022, Rostov-on-Don, Nahichevansky av., 29

tat_kolmakova@mail.ruРостовский государственный медицинский университетРоссияRostov State Medical UniversityRussian Federation2017050920172158084Copyright © Акименко М.А., Тодоров С.С., Колмакова Т.С., 20172017Акименко М.А., Тодоров С.С., Колмакова Т.С.Akimenko M.A., Todorov S.S., Kolmakova T.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/303

THE AIM was to study morphological changes in the contralateral kidney in the dynamics of obstructive uropathy development.

MATERIAL AND METHODS

MATERIAL AND METHODS. Morphological examination of the contralateral kidney with obstructive uropathy on days 7, 14 and 21 revealed a number of characteristic structural changes in the tubular apparatus and interstitial substance.

RESULTS

RESULTS. During the first 7 days of obstruction development, dystrophic changes predominated due to disturbance of waterelectrolyte, protein metabolism (hyaline-droplet, hydrophilic dystrophy of the tubular apparatus), after 14-21 days changes occurred in the stroma of the renal tissue. It should be noted the emergence in these terms of the so-called mesh fibrosis, localized between individual tubular structures of the medulla of the kidney with following the development of neoangiogenesis in it. Conclusion. The described morphofunctional patterns of changes in the contralateral kidney in experimental obstructive uropathy will give an idea of not only the severity of water-electrolyte disorders but also the timing of early development of fibrosis and neoangiogenesis of the renal parenchyma.

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The authors declare that there are no conflicts of interest present.