nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2017-21-6-9-19nefr-308Research ArticleПЕРЕДОВАЯ СТАТЬЯLEADING ARTICLEИММУНОМОРФОЛОГИЧЕСКИЕ ФЕНОТИПЫ ПОВРЕЖДЕНИЯ АЛЛОГРАФТА ПОЧКИIMMUNE AND MORPHOLOGICAL PHENOTYPES OF KIDNEY ALLOGRAFT INJURYДобронравовВ. А.DobronravovV. A.

Добронравов Владимир Александрович - доктор медицинских наук, проф., заместитель  директора.

Vladimir A. Dobronravov - MD, PhD, DSci, vice director.

197022, Lva Tostogo str. 17

dobronravov@nephrolog.ruХраброваМ. С.KhrabrovaM. S.

Храброва Мария Сергеевна - кандидат медицинских наук, кафедра пропедевтики внутренних болезней, ассистент.

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, корп. 54, тел.: (812) 338-01-65

Maria S. Khrabrova - MD, PhD, Department of Propedeutics of Internal Diseases Assistant prof.

197022, Saint-Petersburg, Str. Leo Tolstoy, 17 build 54, +78123380165

hrabrovamc@gmail.comНаучно-исследовательский институт нефрологии Первого Санкт-Петербургского государственного медицинского университета им. акад. И.П. ПавловаРоссияResearch Institute of Nephrology Pavlov First Saint-Petersburg State Medical UniversityRussian FederationПервый Санкт-Петербургский государственный медицинский университет им. акад. И. П. ПавловаРоссияFirst Pavlov Saint-Petersburg State Medical UniversityRussian Federation201728112017216919Copyright © Добронравов В.А., Храброва М.С., 20172017Добронравов В.А., Храброва М.С.Dobronravov V.A., Khrabrova M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/308

Существенным ограничением метода аллотрансплантации почки  является развитие реакций отторжения в результате  активации и  реализации Ти  В-клеточного иммунного ответа,  а  также  иммунных реакций, опосредованных иными  механизмами. В статье приводятся классические и  новые представления  о  развитии  различных иммуноморфологических фенотипов иммунных реакций, происходящих в трансплантированной почке. Основное внимание уделено обсуждению механизмов микроваскулярного воспаления в отсутствие детектируемых донор-специфических антител как самостоятельного фенотипа иммунного повреждения аллографта.

Long-term outcome of kidney transplantation is limited by the development of allograft rejection due  to activation and  realization of Tand  B-cell immune response as well as the effects of other types of immune reactions mediated by various mechanisms. This article is dedicated to nowadays point of view upon the different immune and  morphological phenotypes of kidney transplant injury. Main focus is made on the pathways of microvascular inflammation in the case of donor-specific antibodies absence as the unique self-sustained phenotype of the kidney allograft injury.

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The authors declare that there are no conflicts of interest present.