nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2018-22-1-38-51nefr-330Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESФАРМАКОЭКОНОМИКА ЛЕЧЕНИЯ МКН–ХБП: ОБЗОР ЛИТЕРАТУРЫPHARMACOECONOMIC OF CKD-MBD TREATMENT: LITERATURE REVIEWВишневскийК. А.VishnevskiiK. A.

Вишневский Константин Александрович - кандидат медицинских наук, заведующий отделением хронического гемодиализа.

Konstantin A. Vishnevskii – PhD, head of hemodialysis unit.

198205, St.-Petersburg,   Avangardnaya str. 4, (812)7369342

hd15gb@mail.ruЗемченковА. Ю.ZemchenkovA. Yu.

Земченков Александр Юрьевич - кандидат медицинских наук, доцент кафедры нефрологии  и  диализа ПСПГМУ им. акад. И.П. Павлова; доцент кафедры внутренних болезней и нефрологии СЗГМУ им. И.И. Мечникова.

197022, Санкт-Петербург, ул. Льва Толстого, д. 17; 191015, Санкт-Петербург, ул. Кирочная, д. 41, (812)2757328

Alexander Y. Zemchenkov – PhD, nephrology and dialysis chair FSP I.P. Pavlov SMU, internal diseases and nephrology chair NW I.I. Mechnikov SMU.

197022, St.-Petersburg, L`va Tolstogo str. 17; 191015, St.Petersburg, Kirochnaya str. 41, (812)2757328

kletk@inbox.ruГерасимчукР. П.GerasimchukR. P.

Герасимчук Роман Павлович - кандидат медицинских наук, кафедра внутренних болезней и нефрологии СЗГМУ им. И.И. Мечникова.

191015, Санкт-Петербург,   ул.   Кирочная,   д.   41, (812)2757328

Roman P. Gerasimchuk – PhD, internal diseases and nephrology chair NW I.I. Mechnikov SMU.

191015, St.-Petersburg, Kirochnaya str. 41, (812)2757328

romger@yandex.ruРумянцевА. Ш.RumyantsevA. Sh.

Румянцев Александр Шаликович - доктор медицинских наук, проф. кафедра пропедевтики внутренних болезней ПСПГМУ им. акад. И.П. Павлова; кафедра факультетской терапии медицинского факультета СПГУ.

197022, Санкт-Петербург, ул. Льва Толстого, д. 17; 199034, Санкт-Петербург, Университетская набережная, д. 7/9, (812)2340165

AlexanderS. Rumyantsev- MD, PhD, DMedSci, FSPI.P. PavlovSMU; DepartmentofFacultytherapySPU.

rash.56@mail.ruСмирновА. В.SmirnovA. V.

Смирнов Алексей Владимирович - проф. доктор медицинских наук, заведующий кафедрой пропедевтики   внутренних   болезней ПСПГМУ им. акад. И.П. Павлова.

Alexey V. Smirnov - MD, PhD, DMedSci, head of propedeutics of internal diseases chair

197022, St.-Petersburg, L`va Tolstogo str. 17, (812)2340165

smirnov@nephrolog.ruПарцернякС. А.PartsernyakS. A.

Парцерняк Сергей Александрович - доктор медицинских наук, проф., зам. главного врача по терапии  ГБ №15; , кафедра госпитальной терапии и кардиологии им. М. С. Кушаковского СЗГМУ им. И.И. Мечникова

198205, Санкт-Петербург, ул. Авангардная, д. 4; 191015,, Санкт-Петербург, ул. Кирочная, д. 41, (812) 7350766

Sergey A. Partsernyak - MD, PhD, DMedSci, Deputy Chief of therapy City hospital №15; Hospital Therapy and Cardiology Chair named after M.S. Kushakovsky NW I.I.Mechnikov SMU.

198205, St.-Petersburg, Avangardnaya str. 4; 191015, St.-Petersburg, Kirochnaya str. 41, (812) 7350766

professorpsa@mail.ruМарютинП. В.MaryutinP. V.

Марютин Петр Викторович - кандидат медицинских наук, исполняющий   обязанности   главного   врача.

Petr V. Maryutin - PhD, PhD, Acting  Chief  Physician City  hospital  №15.

198205, St.-Petersburg, Avangardnaya str. 4, (812) 7350766

pvm66@yandex.ruГородская больница №15РоссияSaint Petersburg City hospital №15Russian FederationПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова; Северо-Западный государственный медицинский университет им. И.И. МечниковаРоссияPavlov First Saint Petersburg State Medical University; North-Western I.I.Mechnikov State medical universityRussian FederationСеверо-Западный государственный медицинский университет им. И.И. МечниковаРоссияNorth-Western I.I.Mechnikov State medical universityRussian FederationСанкт- Петербургский государственный университет; Первый Санкт- Петербургский государственный медицинский университет им. акад. И.П. ПавловаРоссияSaint Petersburg State University; Pavlov First Saint Petersburg State Medical UniversityRussian FederationПервый Санкт- Петербургский государственный медицинский университет им. акад. И.П. ПавловаРоссияPavlov First Saint Petersburg State Medical UniversityRussian Federation2018290120182213851Copyright © Вишневский К.А., Земченков А.Ю., Герасимчук Р.П., Румянцев А.Ш., Смирнов А.В., Парцерняк С.А., Марютин П.В., 20182018Вишневский К.А., Земченков А.Ю., Герасимчук Р.П., Румянцев А.Ш., Смирнов А.В., Парцерняк С.А., Марютин П.В.Vishnevskii K.A., Zemchenkov A.Y., Gerasimchuk R.P., Rumyantsev A.S., Smirnov A.V., Partsernyak S.A., Maryutin P.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/330

У большинства пациентов, получающих программный гемодиализ, наблюдаются минерально-костные нарушения, из которых наиболее распространённым является вторичный гиперпаратиреоз. Для коррекции этого жизнеугрожающего осложнения хронической болезни почек в последнее десятилетие разработаны и введены в клиническую практику ряд новых препаратов, таких как парикальцитол, цинакалцет и некоторые фосфат-связывающие медикаменты. Ввиду увеличения государственных затрат на данную  терапию во многих  странах, в том  числе и в России, были  проведены ряд  фармакоэкономических исследований,  призванных определить целесообразность назначения определенных препаратов по критерию «затраты–эффективность». В данном обзоре выполнен краткий анализ методов оценки рентабельности лекарственных препаратов и рассмотрены результаты недавних исследований, посвященных оценке экономической эффективности лечения МКН–ХБП.

In the  majority  of hemodialysis patients there are mineral and  bone disorders, of which  the  most common is secondary hyperparathyroidism. A number of new products such as paricalcitol, cinacalcet and  some phosphate-binding drugs have  been developed and introduced in clinical practice in the past decade in order to correct this life-threatening complication of chronic kidney  disease. A number of pharmacoeconomic studies have  been carried out  to determine the  cost-effectiveness of appointing certain drugs due  to increasing of the  public  expenditure in this therapy in many  countries, including Russia. In this review, we consider a brief analysis of the methods for evaluating the profitability of medicines and the results of recent studies devoted to the evaluation of the cost-effectiveness of CKD-MBD treatment.

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The authors declare that there are no conflicts of interest present.