nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2018-22-1-52-57nefr-331Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESТРАНСПЛАНТАЦИЯ ГЕМОПОЭТИЧЕСКИХ СТВОЛОВЫХ КЛЕТОК И НЕФРОПАТИЯHEMATOPOIETIC STEM CELL TRANSPLANTATION AND NEPHROPATHYКуприенкоН. Б.KuprienkoN. B.

Смирнова Наталия Николаевна - доктор медицинских наук, профессор, кафедра педиатрии.

197022, Санкт-Петербург, ул. Л.Толстого, д. 6–8, 8 (921) 420-49-31

Smirnova Natalia N - MD, PhD, DmedSci, Prof., department of pediatrics.

197022, St-Petersburg, L.Tolstoy str., 6-8, (921) 420-49-31

nephro-uro-kids@mail.ruСмирноваН. Н.SmirnovaN. N.

Куприенко Наталья Борисовна - кандидат медицинских наук, доцент, кафедра педиатрии.

Kuprienko Natalja B. - Senior lecturer, department of pediatrics.

197022, St-Petersburg, L.Tolstoy str., 6-8,  8-951-643-80-86

n-b-k@bk.ruПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова; Национальный медицинский исследовательский центр им. В.А. АлмазоваРоссияPavlov First Saint Petersburg State Medical University; Almazov National Medical Research CentreRussian Federation2018290120182215257Copyright © Куприенко Н.Б., Смирнова Н.Н., 20182018Куприенко Н.Б., Смирнова Н.Н.Kuprienko N.B., Smirnova N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/331

Трансплантация гемопоэтических клеток становится методом лечения многих заболеваний. Почки признаны органоммишенью при острой и хронической болезни «трансплантат против хозяина» (РТПХ). Гломерулопатии значительно сокращают продолжительность жизни  пациентов. Острое повреждение почек  имеет место в первые 100  дней после трансплантации у 15 – 73% пациентов из-за токсичности химиопрепаратов и радиационного облучения. Хроническая РТПХ связана с хронической болезнью почек (ХБП). Наиболее частые клинические варианты ХБП после трансплантации – идиопатический синдром, тромботическая микроангиопатия и нефротический синдром.

Hematopoietic cell transplantation (HCT) is becoming an  increasing common treatment modality for a variety  of diseases. Kidneys  are recognized as a target organ of acute and  chronic graft-versus host disease (GvHD).Glomerulopathy significantly limits patient life-time. Acute kidney injury occurs on average in 100 days after  HCT in 15 – 73% of patients due  to treatmentrelated toxity and radiation. Chronic GvHD is associated with chronic kidney disease. The majority of CKD after  transplantation is idiopathic syndrome, thrombotic microangiopathy and  nephrоtic syndrome.

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The authors declare that there are no conflicts of interest present.