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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nefr</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology (Saint-Petersburg)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-6274</issn><issn pub-type="epub">2541-9439</issn><publisher><publisher-name>Pavlov First Saint-Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1561-6274-2018-22-1-58-68</article-id><article-id custom-type="elpub" pub-id-type="custom">nefr-332</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>ОЦЕНКА ЭФФЕКТИВНОСТИ НЕФРОПРОТЕКТИВНОЙ ТЕРАПИИ (КРАТКИЙ ОБЗОР ЛИТЕРАТУРЫ И ДАННЫЕ САНКТ-ПЕТЕРБУРГСКОГО РЕГИСТРА)</article-title><trans-title-group xml:lang="en"><trans-title>THE EFFICACY EVALUATION OF THE NEPHROPROTECTIVE THERAPY: MINIREVIEW AND SAINT PETERSBURG REGISTRY DATA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Земченков</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Zemchenkov</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Земченков Александр Юрьевич - кафедра внутренних болезней и нефрологии СЗГМУ им. И.И. Мечникова; кафедра нефрологии и диализа ПСПГМУ им. акад. И.П. Павлова.</p><p>191104, Санкт-Петербург, Литейный пр., д. 56, 7(921) 918-01-90</p></bio><bio xml:lang="en"><p>Zemchenkov Alexander Yurievich - PhD., internal disease and nephrology department NWS Mechnicov MU; nephrology and dialysis department Pavlov First SPSMU.</p></bio><email xlink:type="simple">kletk@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Румянцев</surname><given-names>А. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Rumyantsev</surname><given-names>A. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Румянцев Александр Шаликович – профессор, кафедра факультетской терапии СПГУ; кафедра пропедевтики внутренних болезней СПГМУ им. акад. И.П. Павлова.</p></bio><bio xml:lang="en"><p>MD, PhD, DMedSci, Prof., Department of Faculty Therapy SPSU; Department of propedeutic of internal diseases Pavlov First SPSMU.</p><p>199106, Saint Petersburg, V.O., 21 line 8a, +7(812) 326-03-26</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смирнов Алексей Владимирович - профессор, директор.</p><p>197022, Санкт-Петербург,  ул.  Л.  Толстого,  д.  17, корп. 54.</p></bio><bio xml:lang="en"><p>Alexey V. Smirnov - MD, PhD, DMedSci., Prof., director.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Городской нефрологический центр, Городская Мариинская больница; Первый Санкт-Петербургский государственный медицинский университет им. И.П. Павлова; Северо-Западный государственный медицинский университет им. И.И. Мечникова<country>Россия</country></aff><aff xml:lang="en">City Nephrology center, City Mariinsky hospital; Pavlov First Saint Petersburg State Medical University; North-Western State medical university n.a. I.I. Mechnikov<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Санкт-Петербургский государственный университет; Первый Санкт-Петербургский государственный медицинский университет им. И.П. Павлова<country>Россия</country></aff><aff xml:lang="en">Saint  Petersburg State Medical University; Pavlov First Saint  Petersburg State Medical University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">Первый Санкт-Петербургский государственный медицинский университет им. И.П. Павлова<country>Россия</country></aff><aff xml:lang="en">Pavlov First Saint  Petersburg State Medical University<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>29</day><month>01</month><year>2018</year></pub-date><volume>22</volume><issue>1</issue><fpage>58</fpage><lpage>68</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Земченков А.Ю., Румянцев А.Ш., Смирнов А.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Земченков А.Ю., Румянцев А.Ш., Смирнов А.В.</copyright-holder><copyright-holder xml:lang="en">Zemchenkov A.Y., Rumyantsev A.S., Smirnov A.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephrolog.ru/jour/article/view/332">https://journal.nephrolog.ru/jour/article/view/332</self-uri><abstract><p>Распространенность терминальной почечной недостаточности в мире имеет тенденцию к увеличению, что создает значительную дополнительную нагрузку на систему здравоохранения. Это особенно актуально для стран со средним и невысоким валовым национальным доходом относительно численности населения. В статье рассмотрены основные направления и себестоимость нефропротективной терапии. Основными ее компонентами являются интенсификация антигипертензивного лечения, двойная блокада ренин-ангиотензиновой системы, контроль гиперлипидемии статинами, коррекция анемии и недостаточности витамина D, нутриционная поддержка, прекращение курения, ограничение  потребления поваренной соли  и модификация стиля жизни. По данным регистра Санкт-Петербурга, наиболее частыми причинами терминальной почечной недостаточности являются хронический гломерулонефрит (20%), сахарный диабет (16,7%), гипертоническая болезнь (11,8%). У 19,7% диагноз не установлен. Нефропротективная терапия позволяет увеличить длительность додиализного периода на 1,5–2,0 года. При этом рассматриваются минимальные критерии эффективности: снижение величины систолического артериального давления на 5 мм рт. ст. и протеинурии на 0,3 г/сут. В расчете на 1 больного затраты на нефропротекцию составляют 63 100  рублей в год,  тогда как на диализное лечение – 933 005 рублей в год.</p></abstract><trans-abstract xml:lang="en"><p>The prevalence of end stage renal failure in the world tends to increase, creating a significant additional burden on the healthcare system. This is particularly relevant for countries with average and  low gross national income relative  to population. The article considers the basic directions and  costs of nephroprotective therapy. The main components are to intensify antihypertensive treatment, dual  blockade of the  renin-angiotensin system, control of hyperlipidemia with statins, correction of anemia and deficiency of vitamin  D, nutrition support, smoking cessation,  restriction of salt  consumption and  modification of lifestyle. According to the register of Saint Petersburg, the most common causes of end stage renal failure are chronic glomerulonephritis (20%), diabetes (16.7 %), hypertension (11.8 %). In 19,7% cases diagnosis is not established. Renal  protection therapy helps to increase the duration of the predialysis period to 1.5-2.0 years. By considering minimum performance criteria: a decrease in systolic blood pressure by 5 mmHg  and  proteinuria of 0.3 g/day. Per 1 patient costs nephroprotection make 63100 rubles per year, while on dialysis  treatment 933005 rubles per year.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая болезнь почек</kwd><kwd>терминальная почечная недостаточность</kwd><kwd>гемодиализ</kwd><kwd>критерии эффективности</kwd><kwd>нефропротекция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic kidney disease</kwd><kwd>end  stage renal  failure</kwd><kwd>hemodialysis</kwd><kwd>efficacy criteria</kwd><kwd>nephroprotection</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бикбов БТ, Томилина НА. Заместительная терапия терминальной хронической почечной недостаточности в Российской Федерации в 1998-2013 гг. отчет по данным Российского регистра заместительной почечной терапии. Часть первая. 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