nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical Universitynefr-35Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESБиомаркеры в диагностике острого повреждения почек. Сообщение IBiomarkers In The Diagnosis Of Acute Kidney Injury. Communication IПролетовЯ. Ю.ProletovIa. Iu.yan.proletov@gmail.comСагановаЕ. С.SaganovaE. S.noemail@neicon.ruСмирновА. В.SmirnovA. V.noemail@neicon.ruПервый Санкт-Петербургский государственный университет им. акад. И.П. ПавловаRussian Federation2014010720141842535Copyright © Пролетов Я.Ю., Саганова Е.С., Смирнов А.В., 20142014Пролетов Я.Ю., Саганова Е.С., Смирнов А.В.Proletov I.I., Saganova E.S., Smirnov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/35

В последние несколько лет все большее внимание привлекает возможность использования биомаркеров в диагностике острого повреждения почек. Данный факт обусловлен рядом недостатков таких традиционных параметров, как концентрации креатинина и мочевины сыворотки крови, измерение темпа диуреза, которые, с одной стороны, зависят от ряда экстраренальных факторов, с другой - их изменение происходит на поздних, необратимых этапах повреждения почечной ткани. В данной статье проанализированы возможности использования ряда маркеров в ранней диагностике различных вариантов ОПП. В публикующейся первой части работы рассматривается понятие биомаркера, подходы к их классификации, а также доказанная по данным экспериментальных и клинических исследований роль наиболее изученных биомаркеров, таких как нейтрофильный желатиназо-ассоциированный липокалин (NGAL), молекула почечного повреждения (KIM-1), интерлейкин-18, печеночный протеин, связывающий жирные кислоты (L-FABP), цистатин С и др.

In the past few years increasing attention attended to the possibility of using biomarkers in the diagnosis of acute kidney injury because of disadvantages of the traditional parameters such as serum creatinine and urea, diuresis measurement, which on the one hand depends on a number of extrarenal factors, on the other - they change occurs in the later, irreversible stages of renal tissue damage. This article analyzes the possibility of using a number of markers in the early diagnosis of different types of AKI. First part of work discusses the concept of biomarker, approaches to classification, as well as proven according to experimental and clinical studies diagnostic value of the most studied biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule (KIM-1), interleukin- 18, the liver fatty acid binding protein (L-FABP), cystatin C, etc.

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The authors declare that there are no conflicts of interest present.