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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nefr</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology (Saint-Petersburg)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-6274</issn><issn pub-type="epub">2541-9439</issn><publisher><publisher-name>Pavlov First Saint-Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1561-6274-2014-18-1-20-24</article-id><article-id custom-type="elpub" pub-id-type="custom">nefr-4</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ И ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS AND LECTURES</subject></subj-group></article-categories><title-group><article-title>Индоксил сульфат при хронической болезни почек</article-title><trans-title-group xml:lang="en"><trans-title>Indoxyl sulphate at chronic kidney disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лукичёв</surname><given-names>Б. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Lukichev</surname><given-names>B. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Подгаецкая</surname><given-names>О. Ю.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карунная</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Karunnaya</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">a.v.karunnaya@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Румянцев</surname><given-names>А. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Rumyantsev</surname><given-names>A. Sh.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Первый Санкт-Петербургский государственный медицинский университет им акад. И.П. Павлова</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ООО Центр семейной медицины «Моника»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>01</day><month>01</month><year>2014</year></pub-date><volume>18</volume><issue>1</issue><fpage>25</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лукичёв Б.Г., Подгаецкая О.Ю., Карунная А.В., Румянцев А.Ш., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Лукичёв Б.Г., Подгаецкая О.Ю., Карунная А.В., Румянцев А.Ш.</copyright-holder><copyright-holder xml:lang="en">Lukichev B.G., Подгаецкая О.Ю., Karunnaya A.V., Rumyantsev A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephrolog.ru/jour/article/view/4">https://journal.nephrolog.ru/jour/article/view/4</self-uri><abstract><p>В обзоре приведены литературные данные о механизмах токсического действия индоксил сульфата при дисфункции почек.</p></abstract><trans-abstract xml:lang="en"><p>Literary data about the mechanisms of toxic effect of indoxyl sulfate at kidney disfunction are provided in the review.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>индоксил сульфат</kwd><kwd>оксидативный стресс</kwd><kwd>интерстициальный фиброз</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>остеопороз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>indoxyl sulfate</kwd><kwd>oxidative stress</kwd><kwd>interstitial fibrosis</kwd><kwd>cardiovascular diseases</kwd><kwd>osteoporosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Vanholder R., De Smet R., Glorieux G., et al. 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