nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2013-17-5-9-15nefr-433Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESИНТЕРАКТОМИКА – АНАЛИТИЧЕСКИЙ ИНСТРУМЕНТ ДЛЯ ИЗУЧЕНИЯ МОЛЕКУЛЯРНЫХ ОСНОВ НЕФРОПАТИЙINTERACTOMICS: A NOVEL ANALYTICAL INSTRUMENT FOR STUDYING THE MOLECULAR BASIS OF NEPHROPATHIESЗолотухинП. В.ZolotukhinP. V.

344090, г. Ростов-на-Дону, пр-т Стачки, д. 194/1. Факс: (863) 299-56-61, тел.: (863) 297-50-70

p.zolotukhin@icloud.comАлександроваА. А.AleksandrovaA. A.ДовжикА. Д.DovzhikA. D.

факультет биологических наук

ЛебедеваЮ. А.LebedevaU. A.

факультет биологических наук

КузьминоваО. Н.KuzminovaO. N.

факультет биологических наук

ГутниковаЛ. В.GutnikovaL. V.НИИ биологии, Южный федеральный университетRussian FederationЮжный федеральный университетRussian Federation201310052013175915Copyright © Золотухин П.В., Александрова А.А., Довжик А.Д., Лебедева Ю.А., Кузьминова О.Н., Гутникова Л.В., 20132013Золотухин П.В., Александрова А.А., Довжик А.Д., Лебедева Ю.А., Кузьминова О.Н., Гутникова Л.В.Zolotukhin P.V., Aleksandrova A.A., Dovzhik A.D., Lebedeva U.A., Kuzminova O.N., Gutnikova L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/433

Сегодня появилась возможность изучать клеточные процессы с помощью нового инструмента – интерактомики – области биоинформатики и системной биологии, идея которой заключается в объединении данных молекулярных взаимодействий на уровнях от метаболома и до регуляции эпигенома в единые схемы. Объединение в одной аналитической системе свойств высокоинформативных маркерных клеточных и характеристик интерактомики, как технического воплощения системной биологии, позволило получить очень мощный инструмент для подробного изучения функционирования клеток различных тканей, в том числе и при развитии патологических процессов. С точки зрения нефрологии, интерактомика кажется многообещающим подходом для изучения молекулярных основ нефропатий и нарушений продукции почками эритропоэтина.

Interactomics emerges today to become a novel tool for molecular and cellular investigations. Interactomics is an area of bioinformatics and systems biology that relies on the fundamental idea of the necessity to bring the cellular levels (from metabolome and up to epigenome) into single analytical dimension. Such an analytical system may become a powerful tool for the precise investigations of the subtle molecular mechanisms underlying the function of various tissues in both normal and pathologic states. In the aspect of nephrology, interactomics is a highly promising approach to treat a wide range of nephropathies and kidney-related erythropoietin secretion disorders.

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The authors declare that there are no conflicts of interest present.