nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2013-17-4-89-94nefr-476Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИ. КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯORIGINAL ARTICLES. CLINICAL INVESTIGATIONSКЛИНИКО-МОРФОЛОГИЧЕСКИЙ АНАЛИЗ ИЗМЕНЕНИЙ ПЕРИТУБУЛЯРНЫХ МИКРОСОСУДОВ ИНТЕРСТИЦИЯ ПОЧЕК У БОЛЬНЫХ IgA-НЕФРОПАТИЕЙ (IgAN) С ОЦЕНКОЙ АКТИВНОСТИ ЛЕКТИНОВОГО ПУТИ СИСТЕМЫ КОМПЛЕМЕНТАCLINICAL AND MOTPHOLOGIVAL ANALYSIS OF CHANGES OF PERITUBULAR MICROCIRCULATION VESSELS OF FIDNEY INTERSTITIAL TISSUE IN PATIENTS WITH IGA-NEPHROPATHY (IGAN) WITH ESTIMATION OF LECTIN PATHWAY OF COMPLEMENT ACTIVATIONСиповскийВ. Г.SipovskyiV. G.

197022, Санкт-Петербург, ул. Льва Толстого, д. 12. Тел/факс: (812) 234-67-23

sipovski@mail.ruДобронравовВ. А.DobronravovV. A.КоруннаяА. В.KarunnayaA. V.СмирновА. В.SmirnovA. V.НИИ нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П.ПавловаRussian Federation2013100420131748994Copyright © Сиповский В.Г., Добронравов В.А., Корунная А.В., Смирнов А.В., 20132013Сиповский В.Г., Добронравов В.А., Корунная А.В., Смирнов А.В.Sipovskyi V.G., Dobronravov V.A., Karunnaya A.V., Smirnov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/476

Проведено обследование группы больных с IgA нефропатией (IgAN ) с анализом воспалительно-склеротических изменений в тубулоинтерстции (ТИН), а также иммуногистохимической активности C4d – маркера активации лектинового пути комплемента. Количественно и полуколичественно оценивались иммуноглобулины IgG, IgM, IgG, фракции комплемента c1q, C3c, фибриноген, легкие цепи kappa и lambda, количество микрососудов, ТИН с позитивной реакцией на C4d в эндотелии, экстракапиллярная пролиферация, глобальный и сегментарный склероз, мезангиальная пролиферация, интерстициальный фиброз, количество капилляров в ТИН с лейкоцитами – перитубулярный капиллярит ( ПТК), также возраст, пол, суточная протеинурия и сывороточный уровень креатинина, скорость клубочковой фильтрации ( СКФ) по MDRD. В результате были получены данные об активации лектинового пути комплемента в перитубулярных микрососудах, что сопровождается воспалительной реакцией в них и более тяжелым клиническим течением.

The study of a group of patients with IgA-nephropathy (IgAN ) was performed with detailed analysis of inflammatory and sclerotic changes in the tubuloinetrstitium (TIN). As well as immunohistochemical analysis of activity C4d – MBL activation marker of complement pathway. Quantitively and and semiquantitatively were estimated immunoglobulins (IgG, IgM, IgM), complement fractions C1q, C3c, fibrinogen, kappa light chains and lambda deposition, the number of TIN microvessels with – C4d – positive reaction in endothelium. Extracapillary proliferation, global and segmental sclerosis, mesangial proliferation, interstitial fibrosis, the number of peritubular capillaries in the TIN with leukocytes-peritubular capillaritis (PTC), the age, sex, daily proteinuria and serum creatinine, glomerular filtration rate (GFR) by MDRD were evaluated. As a result we have obtained the data about inflammatory activity in TIN microvessels of some patients under IgAN that may signify the partial activation the lectin complement pathway and the more severe clinical course.

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The authors declare that there are no conflicts of interest present.