nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2011-15-2-84-88nefr-485Research ArticleНАБЛЮДЕНИЯ ИЗ ПРАКТИКИPRACTICAL NOTESНЕФРОТИЧЕСКИЙ СИНДРОМ ПРИ ПОЛИКИСТОЗЕ ПОЧЕК: ОПИСАНИЕ ДВУХ СЛУЧАЕВNEPHROTIC SYNDROME IN THE FRAMES OF POLYCYSTIC KIDNEY DISEASE: DESCRIPTION OF TWO CASESКОМИССАРОВК. С.KOMISSAROVK. S.

Кафедра урологии и нефрологии

ДМИТРИЕВАА. М.DMITRIEVAM. V.

Городское клиническое патологоанатомическое бюро

ЦВИРКОТ. Н.TSVIRKOT. N.

отделение нефрологии

ЕФРЕМОВАК. С.EFREMOVK. S.

отделение нефрологии

ПИЛОТОВИЧВ. С.PILOTOVICHV. S.

Кафедра урологии и нефрологии

Белорусская медицинская академия последипломного образованияBelarus1-ая городская клиническая больница г. МинскаBelarus2011100220111528488Copyright © КОМИССАРОВ К.С., ДМИТРИЕВА А.М., ЦВИРКО Т.Н., ЕФРЕМОВА К.С., ПИЛОТОВИЧ В.С., 20112011КОМИССАРОВ К.С., ДМИТРИЕВА А.М., ЦВИРКО Т.Н., ЕФРЕМОВА К.С., ПИЛОТОВИЧ В.С.KOMISSAROV K.S., DMITRIEVA M.V., TSVIRKO t.N., EFREMOV K.S., PILOTOVICH V.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/485

Представлены два случая развития нефротического синдрома у пациенток, страдающих аутосомно-доминантным поликистозом почек. При нефробиопсиях были установлены морфологические диагнозы: IgA-нефропатии и мембранозной нефропатии. Изолированное назначение ингибитора ангиотензин-превращающего фермента не привело к снижению протеинурии, однако его комбинирование с метилпреднизолоном и цитостатиками в течение различных сроков позволило достоверно уменьшить протеинурию и добиться стабилизации почечной функции. Наши случаи показали целесообразность выполнения нефробиопсии у больных с поликистозом почек и нефротическим синдромом с целью определения дальнейшей тактики лечения и профилактики прогрессирования почечной недостаточности.

Two cases of nephrotic syndrome in patients suffering from autosomaldominant polycystic kidney disease is described. During nephrobiopsy were the following morphological diagnoses were stated: IgA-nephropathy and membranous nephropathy. Isolated appointment of ACE inhibitor did not lead to a reduction in proteinuria, but its combination with methyl-prednisolone and cytotoxic drugs for different periods allowed significantly reduce proteinuria and stabilize renal function. Our cases showed the appropriateness of the nephrobiopsy in patients with polycystic kidney disease and nephrotic syndrome in order to determine further management treatment and prevention of progression of renal failure.

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The authors declare that there are no conflicts of interest present.