nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2013-17-3-17-25nefr-493Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESСТРАТЕГИЯ ТЕРАПИИ ДЕБЮТА, РЕЦИДИВИРУЮЩЕГО И ЧАСТО РЕЦИДИВИРУЮЩЕГО ГОРМОНОЧУВСТВИТЕЛЬНОГО И ГОРМОНОЗАВИСИМОГО НЕФРОТИЧЕСКОГО СИНДРОМА С МИНИМАЛЬНЫМИ ИЗМЕНЕНИЯМИ У ДЕТЕЙTREATMENT STRATEGY FOR INITIAL OF RELAPSING AND FREQUENT RELAPSING STEROID SENSITIVE AND STEROID DEPENDENT MINIMAL CHANGE NEPHROTIC SYNDROME IN CHILDRENСавенковаН. Д.SavenkovaN. D.

194100, Литовская ул., д. 2

Savenkova@NS12254.spb.eduГБОУ ВПО Санкт-Петербургский государственный педиатрический медицинский университет Министерства здравоохранения Российской ФедерацииRussian Federation2013100320131731725Copyright © Савенкова Н.Д., 20132013Савенкова Н.Д.Savenkova N.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/493

Представлена стратегия преднизолонотерапии дебюта, кортикостероидной и цитостатической терапии рецидивирующего и часто рецидивирующего, стероидчувствительного, стероидзависимого, со стероидной токсичностью нефротического синдрома с минимальными изменениями (НСМИ) у детей по данным отечественной и зарубежной литературы. Обсуждена цитостатическая терапия алкилирующими соединениями (хлорбутин, циклофосфан), ингибиторами cинтеза кальцинейрина (циклоспорин А), ингибиторами синтеза нуклеотидов (мизорибин, микофенолат мофетил) НСМИ у детей. С прогрессом наших научных знаний и многолетнего опыта «золотой стандарт терапии» в отношении выбора иммуносупрессивного препарата, дозы и продолжительности лечения при НСМИ у детей меняется.

According to the native and foreign literature Strategy of corticosteroid and cytostatic treatment of relapsing and frequent relapsing steroid sensitive and steroid dependent (with steroid toxicity) minimal change nephritic syndrome (MCNS) in children on the onset stage is presented. Administrating details of alkylate compounds (chlorbutin, cyclophosphan), calcineurin synthesis inhibitors (cyclosporine A), nucleotide synthesis inhibitors (mizoribine, micophenolate mofetil) of MCNS in children was discussed. Clinical experience and new scientific findings stipulated change tactic of choice of immunosuppressive preparation, its dosage and treatment duration in MCNS in children.

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The authors declare that there are no conflicts of interest present.