nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2013-17-3-33-45nefr-495Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESПАТОЛОГИЯ ПОЧЕК ПРИ ЮВЕНИЛЬНОМ РЕВМАТОИДНОМ АРТРИТЕ У ДЕТЕЙKIDNEY PATHOLOGY IN JUVENILE RHEUMATOID ARTHRITIS IN CHILDRENСтепановаА. А.StepanovaA. A.

Кафедра факультетской педиатрии 

Санкт-Петербург, ул. Литовская, д. 2. E-mail: ariwka@list.ru. Тел. (812) 416-52-86

savenkova.n.spb@mail.ruГБОУ ВПО Санкт-Петербургский государственный педиатрический медицинский университет Минздрава РоссииRussian Federation2013100320131733345Copyright © Степанова А.А., 20132013Степанова А.А.Stepanova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/495

В обзоре литературы обобщены особенности амилоидной нефропатии при ревматоидном артрите у детей и взрослых пациентов, обсуждено диагностическое значение белка-предшественника амилоида SAA в крови.

Literature review summarize features of amyloid nephropathy in children and adult patients with rheumatoid arthritis, discuss the diagnostic value of the serum amyloid precursor protein (SAA) levels in blood.

ювенильный ревматоидный артритпоражение почекАА-амилоидозсывороточный белокпредшественник амилоида SAAдетиjuvenile rheumatoid arthritiskidney injuryAA amyloidosisserum amyloid precursor protein SAAchildrenReferencesКаневская МЗ, Варшавский ВА. К проблеме ревматоидной нефропатии. Тер арх 2003; 75(5): 24-29Каневская МЗ, Варшавский ВА. К проблеме ревматоидной нефропатии. Тер арх 2003; 75(5): 24-29Koivuniemi R, Paimela L, Leirisalo-Repo M. Causes of death in patients with rheumatoid arthritis from 1971 to 1991 with special reference to autopsy. Clin Rheumatol 2009; 28: 1443–1447Koivuniemi R, Paimela L, Leirisalo-Repo M. Causes of death in patients with rheumatoid arthritis from 1971 to 1991 with special reference to autopsy. Clin Rheumatol 2009; 28: 1443–1447Pathan E, Joshi VR. Rheumatoid Arthritis and The Kidney. JAPI 2004; 52: 488-494Pathan E, Joshi VR. Rheumatoid Arthritis and The Kidney. JAPI 2004; 52: 488-494Алексеева ЕИ, Шахбазян ИВ. Ювенильный ревматоидный артрит. В: Самсыгина ГА, Щербакова МЮ, ред. Кардиология и ревматология детского возраста. ИД Медпрактика-М, М., 2004; 744Алексеева ЕИ, Шахбазян ИВ. Ювенильный ревматоидный артрит. В: Самсыгина ГА, Щербакова МЮ, ред. Кардиология и ревматология детского возраста. ИД Медпрактика-М, М., 2004; 744Алексеева ЕИ, Литвицкий ПФ. Ювенильный ревматоидный артрит: этиология, патогенез, клиника, алгоритмы диагностики и лечения. ВЕДИ, М., 2007; 308Алексеева ЕИ, Литвицкий ПФ. Ювенильный ревматоидный артрит: этиология, патогенез, клиника, алгоритмы диагностики и лечения. ВЕДИ, М., 2007; 308Youn-Soo Hahn, Joong-Gon Kim. Pathogenesis and clinical manifestations of juvenile rheumatoid arthritis. Korean J Pediatr 2010; 53(11): 921-930Youn-Soo Hahn, Joong-Gon Kim. Pathogenesis and clinical manifestations of juvenile rheumatoid arthritis. Korean J Pediatr 2010; 53(11): 921-930Новик ГА, Абакумова ЛН, Летенкова НМ и др. Ювенильные артриты – опыт диагностики и лечения. Лечащий врач 2008; 4: 23-27Новик ГА, Абакумова ЛН, Летенкова НМ и др. Ювенильные артриты – опыт диагностики и лечения. Лечащий врач 2008; 4: 23-27Насонов ЕЛ, ред. Ревматология: Клинические рекомендации. ГЭОТАР-Медиа, М., 2011; 752Насонов ЕЛ, ред. Ревматология: Клинические рекомендации. ГЭОТАР-Медиа, М., 2011; 752Воронцов ИМ, Дубко МФ, Летенкова НМ и др. Ювенильные артриты. Опыт диагностики, клинического группирования и терапии. Вестник Педиатрической академии 2004: 13-19Воронцов ИМ, Дубко МФ, Летенкова НМ и др. Ювенильные артриты. Опыт диагностики, клинического группирования и терапии. Вестник Педиатрической академии 2004: 13-19Папаян АВ, Савенкова НД, ред. Клиническая нефрология детского возраста. Левша. Санкт-Петербург, СПб., 2008; 600Папаян АВ, Савенкова НД, ред. Клиническая нефрология детского возраста. Левша. Санкт-Петербург, СПб., 2008; 600Wallace CA. Current management of juvenile idiopathic arthritis. Practice & Research Clinical Rheumatology 2006; 20(2): 279–300Wallace CA. Current management of juvenile idiopathic arthritis. Practice & Research Clinical Rheumatology 2006; 20(2): 279–300Насонова ВА., Астапенко МГ. Клиническая ревматология: руководство. Медицина, М., 1989; 590Насонова ВА., Астапенко МГ. Клиническая ревматология: руководство. Медицина, М., 1989; 590Arvidsson NG, Gudbjörnsson B, Hällgren R, Larsson A. Concordant message of different inflammatory markers in patients with rheumatoid arthritis. Ups J Med Sci 1998; 103(1): 35-42Arvidsson NG, Gudbjörnsson B, Hällgren R, Larsson A. Concordant message of different inflammatory markers in patients with rheumatoid arthritis. Ups J Med Sci 1998; 103(1): 35-42Саркисова ИА. Ревматоидный артрит как ведущая причина развития вторичного АА-амилоидоза (Обзор литературы). Нефрология и диализ 2006; 8(1): 15-26Саркисова ИА. Ревматоидный артрит как ведущая причина развития вторичного АА-амилоидоза (Обзор литературы). Нефрология и диализ 2006; 8(1): 15-26Sokka T, Envalds M, Pincus T. Treatment of rheumatoid arthritis: a global perspective on the use of antirheumatic drugs. Mod Rheumatol 2008; 18: 228–239Sokka T, Envalds M, Pincus T. Treatment of rheumatoid arthritis: a global perspective on the use of antirheumatic drugs. Mod Rheumatol 2008; 18: 228–239Kwang NK. Treatment of juvenile rheumatoid arthritis. Korean J Pediatr 2010; 53(11): 936-941Kwang NK. Treatment of juvenile rheumatoid arthritis. Korean J Pediatr 2010; 53(11): 936-941Ito S, Tsutsumi A, Harada T et al. Long-term remission of nephrotic syndrome with etanercept for concomitant juvenile idiopathic arthritis. Pediatr Nephrol 2010; 25: 2175–2177Ito S, Tsutsumi A, Harada T et al. Long-term remission of nephrotic syndrome with etanercept for concomitant juvenile idiopathic arthritis. Pediatr Nephrol 2010; 25: 2175–2177Ruperto N, Lovell DJ, Cuttica R et al. Long-term efficacy and safety of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis: fi ndings from an open-label treatment extension. Ann Rheum Dis 2010; 69: 718–722Ruperto N, Lovell DJ, Cuttica R et al. Long-term efficacy and safety of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis: fi ndings from an open-label treatment extension. Ann Rheum Dis 2010; 69: 718–722Boers M, Croonen AM, Dijkmans BAC et al. Renal findings in rheumatoid arthritis: clinical aspects of 132 necropsies. Ann Rheum Dis 1987; 46: 658–663Boers M, Croonen AM, Dijkmans BAC et al. Renal findings in rheumatoid arthritis: clinical aspects of 132 necropsies. Ann Rheum Dis 1987; 46: 658–663Al-Ghamdi A, Attar S. Extra-articular manifestations of rheumatoid arthritis: a hospital-based study. Ann Saudi Med 2009; 29(3): 189-193Al-Ghamdi A, Attar S. Extra-articular manifestations of rheumatoid arthritis: a hospital-based study. Ann Saudi Med 2009; 29(3): 189-193Helin HJ, Korpela MM, Mustonen JT, Pasternack AI. Renal biopsy findings and clinicopathologic correlations in rheumatoid arthritis. Arthritis Rheum 1995; 38(2): 242-247Helin HJ, Korpela MM, Mustonen JT, Pasternack AI. Renal biopsy findings and clinicopathologic correlations in rheumatoid arthritis. Arthritis Rheum 1995; 38(2): 242-247Nakano M, Ueno M, Nishi S et al. Analysis of renal pathology and drug history in 158 Japanese patients with rheumatoid arthritis. Clinical nephrology 1998; 50(3): 154-160Nakano M, Ueno M, Nishi S et al. Analysis of renal pathology and drug history in 158 Japanese patients with rheumatoid arthritis. Clinical nephrology 1998; 50(3): 154-160Karstila K, Korpela M, Sihvonen S, Mustonen J. Prognosis of clinical renal disease and incidence of new renal findings in patients with rheumatoid arthritis: follow-up of a population-based study. Clin Rheumatol 2007; 26(12): 2089-2095Karstila K, Korpela M, Sihvonen S, Mustonen J. Prognosis of clinical renal disease and incidence of new renal findings in patients with rheumatoid arthritis: follow-up of a population-based study. Clin Rheumatol 2007; 26(12): 2089-2095Пономарева ЕЮ, Никитина НМ. Поражение почек при ревматоидном артрите. Нефрология 2004; 8, приложение 2: 145-146Пономарева ЕЮ, Никитина НМ. Поражение почек при ревматоидном артрите. Нефрология 2004; 8, приложение 2: 145-146Harper L, Cockwell P, Howie AJ et al. Focal segmental necrotizing glomerulonephritis in rheumatoid arthritis. Q J Med 1997; 90: 125-132Harper L, Cockwell P, Howie AJ et al. Focal segmental necrotizing glomerulonephritis in rheumatoid arthritis. Q J Med 1997; 90: 125-132Савенкова НД, Папаян АВ. Нефротический синдром в практике педиатра. Эскулап, СПб, 1999; 256Савенкова НД, Папаян АВ. Нефротический синдром в практике педиатра. Эскулап, СПб, 1999; 256Шишкин АН, Янченко ДЕ, Козлов ВВ. Прогностические критерии и выживаемость у больных с вторичным амилоидозом почек. Нефрология 2000; 4: 15-21Шишкин АН, Янченко ДЕ, Козлов ВВ. Прогностические критерии и выживаемость у больных с вторичным амилоидозом почек. Нефрология 2000; 4: 15-21Lachmann H, Gilbertson J, Gallimore R. Natural history and outcome in systemic AA amyloidosis. N Engl J Med 2007; 356: 2361-2371Lachmann H, Gilbertson J, Gallimore R. Natural history and outcome in systemic AA amyloidosis. N Engl J Med 2007; 356: 2361-2371Смирнов АВ, Шилов ЕМ, Добронравов ВA и др. Хроническая болезнь почек: основные принципы скрининга, диагностики, профилактики и подходы к лечению. Национальные рекомендации. Нефрология 2012; 16(1): 89-115Смирнов АВ, Шилов ЕМ, Добронравов ВA и др. Хроническая болезнь почек: основные принципы скрининга, диагностики, профилактики и подходы к лечению. Национальные рекомендации. Нефрология 2012; 16(1): 89-115Suzuki S, Konta T, Koizumi R et al. Fibrillary glomerulonephritis with hypocomplementemia. Internal medicine 2003; 42(8): 719-722Suzuki S, Konta T, Koizumi R et al. Fibrillary glomerulonephritis with hypocomplementemia. Internal medicine 2003; 42(8): 719-722Koseki Y, Terai C, Moriguchi M et al. A prospective study of renal disease in patients with early rheumatoid arthritis. Ann Rheum Dis 2001; 60: 327–331Koseki Y, Terai C, Moriguchi M et al. A prospective study of renal disease in patients with early rheumatoid arthritis. Ann Rheum Dis 2001; 60: 327–331Daoussis D, Panoulas VF, Antonopoulos I et al. Cardiovascular risk factors and not disease activity, severity or therapy associate with renal dysfunction in patients with rheumatoid arthritis. Ann Rheum Dis 2010; 69(3): 517-521Daoussis D, Panoulas VF, Antonopoulos I et al. Cardiovascular risk factors and not disease activity, severity or therapy associate with renal dysfunction in patients with rheumatoid arthritis. Ann Rheum Dis 2010; 69(3): 517-521Gedalia A, Mendez EA, Craver R et al. Renal involvement in juvenile rheumatoid arthritis: report of two cases. Clin Rheumatol 2001; 20: 153–156Gedalia A, Mendez EA, Craver R et al. Renal involvement in juvenile rheumatoid arthritis: report of two cases. Clin Rheumatol 2001; 20: 153–156Varma S. Juvenile rheumatoid arthritis with focal segmental glomerulosclerosis: a rare association. Pediatr Nephrol 2010; 25: 2189–2190Varma S. Juvenile rheumatoid arthritis with focal segmental glomerulosclerosis: a rare association. Pediatr Nephrol 2010; 25: 2189–2190Reed AM, Haugen M, Pachman LM et al. The repair of osteopenia in children with juvenile rheumatoid arthritis. J Pediatr 1993; 122: 693-696Reed AM, Haugen M, Pachman LM et al. The repair of osteopenia in children with juvenile rheumatoid arthritis. J Pediatr 1993; 122: 693-696Батян ГМ, Кожарская ЛГ, Юшко ВД и др. Особенности иммунного статуса больных ювенильным ревматоидным артритом (ЮРА) с поражением почек. Материалы Всероссийской научно-практической конференции «проблемы детской нефрологии», посвящённой 75-летию НИИ педиатрии РАМН (Москва 15-16 октября 1997). М., 1997: 25Батян ГМ, Кожарская ЛГ, Юшко ВД и др. Особенности иммунного статуса больных ювенильным ревматоидным артритом (ЮРА) с поражением почек. Материалы Всероссийской научно-практической конференции «проблемы детской нефрологии», посвящённой 75-летию НИИ педиатрии РАМН (Москва 15-16 октября 1997). М., 1997: 25Pedersen LM, Nordin H, Svensson B, Bliddal H. Microalbuminuria in patients with rheumatoid arthritis. Ann Rheum Dis 1995; 54: 189-192Pedersen LM, Nordin H, Svensson B, Bliddal H. Microalbuminuria in patients with rheumatoid arthritis. Ann Rheum Dis 1995; 54: 189-192Витворт ДжА, Лоренс Дж Р, ред. Руководство по нефрологии. Перевод с англ. Под ред. Ю.В. Наточина. Медицина, М., 2000; 486Витворт ДжА, Лоренс Дж Р, ред. Руководство по нефрологии. Перевод с англ. Под ред. Ю.В. Наточина. Медицина, М., 2000; 486Sharma R, Jain S, Kher V. ANCA-associated Goodpasture’s syndrome in a patient with rheumatoid arthritis on penicillamine. Indian J Nephrol 2012; 22(1): 45–47Sharma R, Jain S, Kher V. ANCA-associated Goodpasture’s syndrome in a patient with rheumatoid arthritis on penicillamine. Indian J Nephrol 2012; 22(1): 45–47Stokes MB, Foster K, Markowitz GS et al. Development of glomerulonephritis during anti-TNF-alpha therapy for rheumatoid arthritis. Nephrol Dial Transplant 2005; 20(7): 1400-1406Stokes MB, Foster K, Markowitz GS et al. Development of glomerulonephritis during anti-TNF-alpha therapy for rheumatoid arthritis. Nephrol Dial Transplant 2005; 20(7): 1400-1406Yilmaz M, Unsal A, Sokmen M et al. Duodenal biopsy for diagnosis of renal involvement in amyloidosis. Clin Nephrol 2012; 77(2): 114-118Yilmaz M, Unsal A, Sokmen M et al. Duodenal biopsy for diagnosis of renal involvement in amyloidosis. Clin Nephrol 2012; 77(2): 114-118Gertz MA, Kyle RA. Secondary systemic amyloidosis: response and survival in 64 patients. Medicine (Baltimore) 1991; 70(4): 246-256Gertz MA, Kyle RA. Secondary systemic amyloidosis: response and survival in 64 patients. Medicine (Baltimore) 1991; 70(4): 246-256Рамеев ВВ, Козловская ЛВ, Саркисова ИА. Амилоидоз: вопросы диагностики и лечения. Клиницист 2006; 4: 35-41Рамеев ВВ, Козловская ЛВ, Саркисова ИА. Амилоидоз: вопросы диагностики и лечения. Клиницист 2006; 4: 35-41Immonen K, Pettersson T, Finne P et al. Decline in the incidence of renal failure due to amyloidosis associated with inflammatory rheumatic diseases. Amyloid 2010; 17 (Suppl 1): 149Immonen K, Pettersson T, Finne P et al. Decline in the incidence of renal failure due to amyloidosis associated with inflammatory rheumatic diseases. Amyloid 2010; 17 (Suppl 1): 149Koivuniemi R, Paimela L, Suomalainen R et al. Amyloidosis is frequently undetected in patients with rheumatoid arthritis. Amyloid 2008; 15(4): 262-268Koivuniemi R, Paimela L, Suomalainen R et al. Amyloidosis is frequently undetected in patients with rheumatoid arthritis. Amyloid 2008; 15(4): 262-268Малкоч АВ, Хасабов НН. Амилоидоз. В: Таболин ВА, Бельмер СВ, Османов ИМ, ред. Нефрология детского возраста. ИД МЕДПРАКТИКА-М, М., 2005; 519-538Малкоч АВ, Хасабов НН. Амилоидоз. В: Таболин ВА, Бельмер СВ, Османов ИМ, ред. Нефрология детского возраста. ИД МЕДПРАКТИКА-М, М., 2005; 519-538Шишкин АН. Амилоидные болезни. Медицина XXI век 2008; 9(10): 44-51Шишкин АН. Амилоидные болезни. Медицина XXI век 2008; 9(10): 44-51Bergesio F, Ciciani AM, Santostefano M et al. Renal involvement in systemic amyloidosis – an Italian retrospective study on epidemiological and clinical data at diagnosis. Nephrol Dial Transplant 2007; 22: 1608–1618Bergesio F, Ciciani AM, Santostefano M et al. Renal involvement in systemic amyloidosis – an Italian retrospective study on epidemiological and clinical data at diagnosis. Nephrol Dial Transplant 2007; 22: 1608–1618Tuglular S, Yalcinkaya F, Paydas S et al. A retrospective analysis for aetiology and clinical findings of 287 secondary amyloidosis cases in Turkey. Nephrol Dial Transplant 2002; 17: 2003-2005Tuglular S, Yalcinkaya F, Paydas S et al. A retrospective analysis for aetiology and clinical findings of 287 secondary amyloidosis cases in Turkey. Nephrol Dial Transplant 2002; 17: 2003-2005Кочубей ЛН, Виноградова ОМ, Серов ВВ, Васильева НА. Прогноз и выживаемость больных вторичным амилоидозом (анализ 146 случаев). Тер. арх 1993; 6: 48-54Кочубей ЛН, Виноградова ОМ, Серов ВВ, Васильева НА. Прогноз и выживаемость больных вторичным амилоидозом (анализ 146 случаев). Тер. арх 1993; 6: 48-54Potysova Z, Merta M, Tesar V et al. Renal AA amyloidosis: survey of epidemiologic and laboratory data from one nephrology centre. Int Urol Nephrol 2009; 41: 941–945Potysova Z, Merta M, Tesar V et al. Renal AA amyloidosis: survey of epidemiologic and laboratory data from one nephrology centre. Int Urol Nephrol 2009; 41: 941–945Chevrel G, Jenvrin C, McGregor B, Miossec P. Renal type AA amyloidosis associated with rheumatoid arthritis: a cohort study showing improved survival on treatment with pulse cyclophosphamide. Rheumatology 2001; 40: 821–825Chevrel G, Jenvrin C, McGregor B, Miossec P. Renal type AA amyloidosis associated with rheumatoid arthritis: a cohort study showing improved survival on treatment with pulse cyclophosphamide. Rheumatology 2001; 40: 821–825Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. The New England Journal of Medicine 1997; 25: 898-909Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. The New England Journal of Medicine 1997; 25: 898-909Рамеев ВВ, Козловская ЛВ, Малинина ЕА и др. Определение циркулирующих белков-предшественников амилоида в диагностике и мониторировании течения системного амилоидоза. Клиническая нефрология 2009; 55-62Рамеев ВВ, Козловская ЛВ, Малинина ЕА и др. Определение циркулирующих белков-предшественников амилоида в диагностике и мониторировании течения системного амилоидоза. Клиническая нефрология 2009; 55-62Wilkins J, Gallimore JR, Tennent GA et al. Rapid Automated Enzyme Immunoassay of Serum Amyloid A. Clin. Chem. 1994; 40(7): 1284-1290Wilkins J, Gallimore JR, Tennent GA et al. Rapid Automated Enzyme Immunoassay of Serum Amyloid A. Clin. Chem. 1994; 40(7): 1284-1290Lannergård A, Friman G, Ewald U et al. Serum amyloid A (SAA) protein and high-sensitivity C-reactive protein (hsCRP) in healthy newborn infants and healthy young through elderly adults. Acta Paediatr 2005; 94(9): 1198-1202Lannergård A, Friman G, Ewald U et al. Serum amyloid A (SAA) protein and high-sensitivity C-reactive protein (hsCRP) in healthy newborn infants and healthy young through elderly adults. Acta Paediatr 2005; 94(9): 1198-1202Obici L, Raimondi S, Lavatelli F et al. Susceptibility to AA amyloidosis in rheumatic diseases: a critical overview. Arthritis & Rheumatism 2009; 61(10): 1435–1440Obici L, Raimondi S, Lavatelli F et al. Susceptibility to AA amyloidosis in rheumatic diseases: a critical overview. Arthritis & Rheumatism 2009; 61(10): 1435–1440Cunnane G, Grehan S, Geoghegan S et al. Serum amyloid A in the assessment of early inflammatory arthritis. Journal of Rheumatology 2000; 27: 58–63Cunnane G, Grehan S, Geoghegan S et al. Serum amyloid A in the assessment of early inflammatory arthritis. Journal of Rheumatology 2000; 27: 58–63Li TW, Zheng BR, Huang ZX et al. Screening diseaseassociated proteins from sera of patients with rheumatoid arthritis: a comparative proteomic study. Chinese Medical Journal 2010; 123(5): 537-543Li TW, Zheng BR, Huang ZX et al. Screening diseaseassociated proteins from sera of patients with rheumatoid arthritis: a comparative proteomic study. Chinese Medical Journal 2010; 123(5): 537-543Targoñska-Stêpniak B, Dryglewska M, Majdan M. Influence of long-term leflunomide treatment on serum amyloid concentration in rheumatoid arthritis patients. Pharmocological reports 2010; 62: 719-725Targoñska-Stêpniak B, Dryglewska M, Majdan M. Influence of long-term leflunomide treatment on serum amyloid concentration in rheumatoid arthritis patients. Pharmocological reports 2010; 62: 719-725Verine J, Mourad N, Desseaux K et al. Clinical and histological characteristics of renal AA amyloidosis: a retrospective study of 68 cases with a special interest to amyloid-associated inflammatory response. Hum Pathol 2007; 38(12): 1798-1809Verine J, Mourad N, Desseaux K et al. Clinical and histological characteristics of renal AA amyloidosis: a retrospective study of 68 cases with a special interest to amyloid-associated inflammatory response. Hum Pathol 2007; 38(12): 1798-1809Nakamura T. Amyloid A amyloidosis secondary to rheumatoid arthritis: pathophysiology and treatment. Clin Exp Rheumatol 2011; 850–856Nakamura T. Amyloid A amyloidosis secondary to rheumatoid arthritis: pathophysiology and treatment. Clin Exp Rheumatol 2011; 850–856Yamada T, Sato J, Okuda Y. Affinity of SAA with HDL may partially interpret SAA1 polymorphism related AA amyloidogenesis. Amyloid 2010; 17 (Suppl 1): 94Yamada T, Sato J, Okuda Y. Affinity of SAA with HDL may partially interpret SAA1 polymorphism related AA amyloidogenesis. Amyloid 2010; 17 (Suppl 1): 94Magy N, Benson MD, Liepnieks JJ et al. Cellular events associated with the initial phase of AA amyloidogenesis: insights from a human monocyte model. Amyloid 2007; 14(1): 51-63Magy N, Benson MD, Liepnieks JJ et al. Cellular events associated with the initial phase of AA amyloidogenesis: insights from a human monocyte model. Amyloid 2007; 14(1): 51-63Connolly M, Veale DJ, Fearon U. Acute serum amyloid A regulates cytoskeletal rearrangement, cell matrix interactions and promotes cell migration in rheumatoid arthritis. Ann Rheum Dis 2011; 70(7): 1296-1303Connolly M, Veale DJ, Fearon U. Acute serum amyloid A regulates cytoskeletal rearrangement, cell matrix interactions and promotes cell migration in rheumatoid arthritis. Ann Rheum Dis 2011; 70(7): 1296-1303Cai H, Song C, Endoh I et al. Serum amyloid A induces monocyte tissue factor. J Immunol 2007; 178: 1852-1860Cai H, Song C, Endoh I et al. Serum amyloid A induces monocyte tissue factor. J Immunol 2007; 178: 1852-1860Okamoto H, Katagiri Y, Kiire A et al. Serum amyloid A activates nuclear factor-kappaB in rheumatoid synovial fibroblasts through binding to receptor of advanced glycation end-products. J Rheumatol 2008; 35(5): 752-756Okamoto H, Katagiri Y, Kiire A et al. Serum amyloid A activates nuclear factor-kappaB in rheumatoid synovial fibroblasts through binding to receptor of advanced glycation end-products. J Rheumatol 2008; 35(5): 752-756Степанова АА, Савенкова НД, Новик ГА и др. Концентрация сывороточного белка-предшественника амилоида в крови у больных ювенильным ревматоидным артритом, имеющих протеинурию. Нефрология 2012; 16(3), выпуск 2: 48-53Степанова АА, Савенкова НД, Новик ГА и др. Концентрация сывороточного белка-предшественника амилоида в крови у больных ювенильным ревматоидным артритом, имеющих протеинурию. Нефрология 2012; 16(3), выпуск 2: 48-53Okuda Y, Takasugi K, Oyama T et al. Amyloidosis in rheumatoid arthritis: clinical study of 124 histologically proven cases. Ryumachi 1994; 34: 939-946Okuda Y, Takasugi K, Oyama T et al. Amyloidosis in rheumatoid arthritis: clinical study of 124 histologically proven cases. Ryumachi 1994; 34: 939-946Kuroda T, Tanabe N, Kobayashi D et al. Significant association between renal function and area of amyloid deposition in kidney biopsy specimens in reactive amyloidosis associated with rheumatoid arthritis. Rheumatol Int 2012; 32(10): 3155-3162Kuroda T, Tanabe N, Kobayashi D et al. Significant association between renal function and area of amyloid deposition in kidney biopsy specimens in reactive amyloidosis associated with rheumatoid arthritis. Rheumatol Int 2012; 32(10): 3155-3162Hamberg H, Westermark GT, Davey E, Westermark P. Renal papillary necrosis in systemic amyloidoses. Amyloid 2010; 17 (Suppl 1): 183Hamberg H, Westermark GT, Davey E, Westermark P. Renal papillary necrosis in systemic amyloidoses. Amyloid 2010; 17 (Suppl 1): 183Benucci M, Maniscalchi F, Manfredi M. Secondary amyloidosis complicated rheumatoid arthritis, prevalence study in Italian population. Recenti Prog Med 2007; 98(1): 16-19Benucci M, Maniscalchi F, Manfredi M. Secondary amyloidosis complicated rheumatoid arthritis, prevalence study in Italian population. Recenti Prog Med 2007; 98(1): 16-19Anelli MG, Torres DD, Manno C et al. Improvement of renal function and disappearance of hepatitis B virus DNA in a patient with rheumatoid arthritis and renal amyloidosis following treatment with infliximab. Arthritis & Rheumatism 2005; 52(8): 2519–2520Anelli MG, Torres DD, Manno C et al. Improvement of renal function and disappearance of hepatitis B virus DNA in a patient with rheumatoid arthritis and renal amyloidosis following treatment with infliximab. Arthritis & Rheumatism 2005; 52(8): 2519–2520Perry ME, Stirling A, Hunter JA. Effect of etanercept on serum amyloid A protein (SAA) levels in patients with AA amyloidosis complicating inflammatory arthritis. Clin Rheumatol 2008; 27(7): 923-925Perry ME, Stirling A, Hunter JA. Effect of etanercept on serum amyloid A protein (SAA) levels in patients with AA amyloidosis complicating inflammatory arthritis. Clin Rheumatol 2008; 27(7): 923-925Kuroda T, Wada Y, Kobayashi D et al. Effective anti-TNFalpha therapy can induce rapid resolution and sustained decrease of gastroduodenal mucosal amyloid deposits in reactive amyloidosis associated with rheumatoid arthritis. J Rheumatol 2009; 36(11): 2409-2415Kuroda T, Wada Y, Kobayashi D et al. Effective anti-TNFalpha therapy can induce rapid resolution and sustained decrease of gastroduodenal mucosal amyloid deposits in reactive amyloidosis associated with rheumatoid arthritis. J Rheumatol 2009; 36(11): 2409-2415Kuroda T, Tanabe N, Kobayashi D et al. Treatment with biologic agents improves the prognosis of patients with rheumatoid arthritis and amyloidosis. J Rheumatol 2012; 39(7): 1348-1354Kuroda T, Tanabe N, Kobayashi D et al. Treatment with biologic agents improves the prognosis of patients with rheumatoid arthritis and amyloidosis. J Rheumatol 2012; 39(7): 1348-1354Blank N, Lorenz HM. Diagnostics and therapy of AA amyloidosis. Pathologe 2009; 30(3): 219-225Blank N, Lorenz HM. Diagnostics and therapy of AA amyloidosis. Pathologe 2009; 30(3): 219-225Murata S, Ueda M, Tanabe Y et al. Inhibitory effects of anti-IL-1 beta antibody in murine AA amyloidosis model. Amyloid 2010; 17 (Suppl 1): 114Murata S, Ueda M, Tanabe Y et al. Inhibitory effects of anti-IL-1 beta antibody in murine AA amyloidosis model. Amyloid 2010; 17 (Suppl 1): 114Kluve-Beckerman B, Benson MD. AA amyloidosis: potential therapy with antisense oligonucleotides. Amyloid 2010; 17 (Suppl 1): 117Kluve-Beckerman B, Benson MD. AA amyloidosis: potential therapy with antisense oligonucleotides. Amyloid 2010; 17 (Suppl 1): 117Wien TN, Leivestad T, Reisæter AV et al. Kidney transplantation in AA amyloidosis. Amyloid 2010; 17 (Suppl 1): 117Wien TN, Leivestad T, Reisæter AV et al. Kidney transplantation in AA amyloidosis. Amyloid 2010; 17 (Suppl 1): 117Gillmore JD, Lovat L.B, Persey MR et al. Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein. Lancet 2001; 358(9275): 4-5Gillmore JD, Lovat L.B, Persey MR et al. Amyloid load and clinical outcome in AA amyloidosis in relation to circulating concentration of serum amyloid A protein. Lancet 2001; 358(9275): 4-5Kuroda T, Tanabe N, Harada T et al. Long-term mortality outcome in patients with reactive amyloidosis associated with rheumatoid arthritis. Clin Rheumatol 2006; 25: 498–505Kuroda T, Tanabe N, Harada T et al. Long-term mortality outcome in patients with reactive amyloidosis associated with rheumatoid arthritis. Clin Rheumatol 2006; 25: 498–505Ueno T, Takeda K, Nagata M. Remission of proteinuria and preservation of renal function in patients with renal AA amyloidosis secondary to rheumatoid arthritis. Nephrol Dial Transplant 2012; 27(2): 633-639Ueno T, Takeda K, Nagata M. Remission of proteinuria and preservation of renal function in patients with renal AA amyloidosis secondary to rheumatoid arthritis. Nephrol Dial Transplant 2012; 27(2): 633-639

The authors declare that there are no conflicts of interest present.