nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2013-17-2-39-54nefr-506Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESСТРЕСС ЭНДОПЛАЗМАТИЧЕСКОГО РЕТИКУЛУМА ГЛАЗАМИ НЕФРОЛОГА (СООБЩЕНИЕ II)ENDOPLASMTIC RETICULUM STRESS IN TERMSOF NEPHROLOGIST (MESSAGE II)ЗверевЯ. Ф.ZverevYa. F.

Кафедра фармакологии 

656038, г. Барнаул, пр. Ленина, д. 40. Тел.: (3852)26-08-35

zver@asmu.ruБрюхановВ. М.BryuhanovV. M.

Кафедра фармакологии

Алтайский государственный медицинский университетRussian Federation2013100220131723954Copyright © Зверев Я.Ф., Брюханов В.М., 20132013Зверев Я.Ф., Брюханов В.М.Zverev Y.F., Bryuhanov V.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/506

В обзоре приводятся сведения о роли стресса эндоплазматического ретикулума (ЭПР-стресса) в развитии ряда почечных заболеваний. Обсуждается участие ЭПР-стресса в патогенезе врожденных и наследственных заболеваний почек, различных форм гломерулопатий. Рассматривается вовлечение ЭПР-стресса в развитие повреж дений почечных канальцев, в том числе – при воздействии ксенобиотиков, а также в патогенез диабетической нефропатии.

The review provides information on the role of endoplasmic reticulum stress (EPR-stress) in the development of a number of renal diseases. Participation of EPR-stress in pathogenesis of congenital and hereditary kidney diseases, various forms of glomerulopathies is discussed. Involvement of EPR-stress in development of renal tubules injury, including induced by xenobiotics, as well as in pathogenesis of diabetic nephropathy s considered.

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The authors declare that there are no conflicts of interest present.