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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nefr</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology (Saint-Petersburg)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-6274</issn><issn pub-type="epub">2541-9439</issn><publisher><publisher-name>Pavlov First Saint-Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">nefr-51</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАБЛЮДЕНИЯ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICAL NOTES</subject></subj-group></article-categories><title-group><article-title>Клинический случай быстрого формирования дисфункции почек у пациента с артериальной гипертензией</article-title><trans-title-group xml:lang="en"><trans-title>Clinical case of the rapid pace of the chronic renal failure formation in patients with arterial hypertension</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Руденко</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudenko</surname><given-names>L. I.</given-names></name></name-alternatives><email xlink:type="simple">rostgmu-nauka@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Батюшин</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Batyushin</surname><given-names>M. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пасечник</surname><given-names>Д. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Pasechnik</surname><given-names>D. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логвинов</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Logvinov</surname><given-names>A. K.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Ростовский государственный медицинский университет<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>01</day><month>09</month><year>2014</year></pub-date><volume>18</volume><issue>5</issue><fpage>70</fpage><lpage>75</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Руденко Л.И., Батюшин М.М., Пасечник Д.Г., Логвинов А.К., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Руденко Л.И., Батюшин М.М., Пасечник Д.Г., Логвинов А.К.</copyright-holder><copyright-holder xml:lang="en">Rudenko L.I., Batyushin M.M., Pasechnik D.G., Logvinov A.K.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephrolog.ru/jour/article/view/51">https://journal.nephrolog.ru/jour/article/view/51</self-uri><abstract><p>Представлен случай быстрого прогрессирования дисфункции почек у пациента с асимптомной гипертонической нефропатией. При нефробиопсии обнаружены признаки гипертензивного нефросклероза (артериоартериолонефросклероз). В подтверждение семейного анамнеза был выявлен гетерозиготный тип полиморфизма по генам, регулирующим артериальное давление. Начата антигипертензивная терапия блокатором рецепторов ангиотензина и диуретиком.</p></abstract><trans-abstract xml:lang="en"><p>Case of fast development of chronic renal failure in patients with asymptomatic hypertensive nephropathy is presented. The patient was performed a renal puncture biopsy - hypertensive nephrosclerosis (arterio-arteriosclerosis) was revealed. In confirmation of family history it was dentified a heterozygous type of polymorphisms in genes that regulate blood pressure. Patient started antihypertensive therapy with receptor blocker angiotensin and diuretics.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гипертоническая нефропатия</kwd><kwd>семейный анамнез хронической почечной недостаточности</kwd><kwd>однонуклеотидный полиморфизм генов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypertensive nephropathy</kwd><kwd>family history of chronic kidney failure</kwd><kwd>single nucleotide gene polymorphism</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wang X.-C., Liu C.-H., Chen Y.-J. Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy. Exp Ther Med 2013; 6(5): 1243-1246.</mixed-citation><mixed-citation xml:lang="en">Wang X.-C., Liu C.-H., Chen Y.-J. Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy. 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