nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2018-22-4-50-56nefr-517Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESКЛИНИЧЕСКОЕ ЗНАЧЕНИЕ ОПРЕДЕЛЕНИЯ ЛИПОКАЛИНА-2, АССОЦИИРОВАННОГО С НЕЙТРОФИЛЬНОЙ ЖЕЛАТИНАЗОЙ, У ПАЦИЕНТОВ С ХРОНИЧЕСКОЙ БОЛЕЗНЬЮ ПОЧЕК (ОБЗОР ЛИТЕРАТУРЫ)CLINICAL SIGNIFICANCE OF DETERMINATION OF LIPOCALIN-2 ASSOCIATED WITH NEUTROPHILIC GELATINASE IN PATIENTS WITH CHRONIC KIDNEY DISEASE (LITERATURE REVIEW)ЕремееваА. В.EremeevaA. V.

119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2

Доц. Еремеева Алина Владимировна, канд. мед. наук, доцент кафедры педиатрии и детских инфекционных болезней Тел.: 8-916-670-14-87

8/2 Trubetskaya St., Moscow, Russia, 119991

Eremeeva Alina Vladimirovna, MD, PhD Associate prof. of the  Chair of Pediatrics and Children’s Infectious Diseases Tel.: +7-916-670-14-87

alinaeremeeva@yandex.ruДлинВ. В.DlinV. V.

125412, Россия, Москва, ул. Талдомская, д. 2

Проф. Длин Владимир Викторович, д-р мед. наук, заместитель директора по научной работе   Тел.: 8-916-634-34-53

2 Taldomskaya St., Moscow, Russia, 125412

Professor Dlin Vladimir Viktorovich, MD, PhD, DMedSciDeputy Director for Science Tel.: +7-916-634-34-53

 

vvdlin@mail.ruКорсунскийА. А.KorsunskyA. A.

119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2

Проф. Корсунский Анатолий Александрович, д-р мед. наук, зав. кафедрой педиатрии и детских инфекционных болезней Тел.: 8-495-256-21-62

8/2 Trubetskaya St., Moscow, Russia, 119991

Professor Korsunsky Anatoly Alexandrovich, MD, PhD, DMedSciHead of the Chair of Pediatrics and Children’s Infectious Diseases Tel.: +7-495-256-21-62

dr_kaa@mail.ruЗайковаН. М.ZaikovaN. M.

119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2

Зайкова Наталья Михайловна, канд. мед. наук, ассистент кафедры педиатрии и детских инфекционных болезней Тел.: 8-964-529-90-49

8/2 Trubetskaya St., Moscow, Russia, 119991

Zaikova Natalia Mikhailovna, MD, PhD Assistant of the Chair of Pediatrics and Children’s Infectious  Diseases, Tel: +7-964-529-90-49

nataliazaikova@mail.ruБондаренкоЕ. Д.BondarenkoE. D.

119991, Россия, Москва, ул. Трубецкая, д. 8, стр. 2

Бондаренко Елена Дмитриевна, канд. мед. наук, ассистент кафедры педиатрии и детских инфекционных болезней Тел.: 8-916-098-75-63

8/2 Trubetskaya St., Moscow, Russia, 119991

Bondarenko Elena Dmitrievna, MD, PhD Assistant of the Chair of Pediatrics and Children’s Infectious Diseases Tel.: +7-916-098-75-63

alenkabond@gmail.comПервый Московский государственный медицинский университет им. И.М. СеченоваРоссияI.M. Sechenov First Moscow State Medical UniversityRussian FederationНаучно-исследовательский клинический институт педиатрии им. акад. Ю.Е. Вельтищева Российского национального исследовательского медицинского университета им. Н.И. ПироговаРоссияYu.E. Veltishchev Scientific Research Clinical Institute of Pediatrics, N.I. Pirogov Russian National Research Medical UniversityRussian Federation2018210720182245056Copyright © Еремеева А.В., Длин В.В., Корсунский А.А., Зайкова Н.М., Бондаренко Е.Д., 20182018Еремеева А.В., Длин В.В., Корсунский А.А., Зайкова Н.М., Бондаренко Е.Д.Eremeeva A.V., Dlin V.V., Korsunsky A.A., Zaikova N.M., Bondarenko E.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/517

Совершенствование методов диагностики и прогнозирования хронической болезни почек связано с выявлением и изучением новых биомаркеров, не зависящих от фильтрационной  функции почек. В обзоре литературы представлены данные по изучению роли липокалина-2,  ассоциированного с нейтрофильной желатиназой, в диагностике, оценке степени выраженности и темпов прогрессирования хронической болезни почек как у взрослых, так и у детей.

Improvement of diagnosis and prediction methods of the chronic kidney disease is associated with the identification and studying of new  biomarkers, not depending on kidney filtration function. In this literature review we present the research data of Lipocalin-2 associated with  neutrophilic gelatinase in diagnostics, assessment of severity and rate of  progression of chronic kidney disease both in adults and children.

s-NGALu-NGALхроническая болезнь почекs-NGALu-NGALchronic kidney diseaseReferencesKjeldsen L, Okamoto K, Arito M et al. Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. Blood 1994;83:799–807Kjeldsen L, Okamoto K, Arito M et al. Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils. Blood 1994;83:799–807Chu ST, Lin HJ, Huang HL, Chen YH. The hydrophobic pocket of 24p3 protein from mouse uterine luminal fluid: fatty acid and retinol binding activity and predicted structural similarity to lipocalins. J Pept Res 1998;52:390–397Chu ST, Lin HJ, Huang HL, Chen YH. The hydrophobic pocket of 24p3 protein from mouse uterine luminal fluid: fatty acid and retinol binding activity and predicted structural similarity to lipocalins. J Pept Res 1998;52:390–397Bao G, Clifton M, Hoette TM et al. Iron traffics in circulation bound to a siderocalin (Ngal)- catechol complex. Nat Chem Biol 2010;6:602–609Bao G, Clifton M, Hoette TM et al. Iron traffics in circulation bound to a siderocalin (Ngal)- catechol complex. Nat Chem Biol 2010;6:602–609Xuang HL, Chu ST, Chen YH. Ovarian steroids regulate 24p3 expression in mouse uterus during the natural estrous cycle and the preimplantation period. J Endocrinol 1999;162:11–19Xuang HL, Chu ST, Chen YH. Ovarian steroids regulate 24p3 expression in mouse uterus during the natural estrous cycle and the preimplantation period. J Endocrinol 1999;162:11–19Borregaard N, Cowland JB. Neutrophil gelatinase-associated lipocalin, a siderophore- binding eukaryotic protein. Biometals 2006;19:211–215Borregaard N, Cowland JB. Neutrophil gelatinase-associated lipocalin, a siderophore- binding eukaryotic protein. Biometals 2006;19:211–215Aigner F, Maier HT, Schwelberger HG et al. Lipocalin-2 regulates the inflammatory response during ischemia and reperfusion of the transplanted heart. Am J Transplant 2007; 7:779–788Aigner F, Maier HT, Schwelberger HG et al. Lipocalin-2 regulates the inflammatory response during ischemia and reperfusion of the transplanted heart. Am J Transplant 2007; 7:779–788Cowland JB, Borregaard N. Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinaseassociated lipocalin from humans. Genomics 1997; 45:17–23Cowland JB, Borregaard N. Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinaseassociated lipocalin from humans. Genomics 1997; 45:17–23Owen HC, Roberts SJ, Ahmed SF, Farquharson C. Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes. Am J Physiol Endocrinol Metabol 2008; 294:1023–1034Owen HC, Roberts SJ, Ahmed SF, Farquharson C. Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes. Am J Physiol Endocrinol Metabol 2008; 294:1023–1034Yan QW, Yang Q, Mody N et al. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 2007; 56:2533–2540Yan QW, Yang Q, Mody N et al. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 2007; 56:2533–2540Devireddy LR, Teodoro JG, Richard FA, Green MR. Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Science 2001; 293:829–834Devireddy LR, Teodoro JG, Richard FA, Green MR. Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Science 2001; 293:829–834Yang J, Goetz D, Li JY et al. An iron delivery pathway mediated by a lipocalin. Mol Cell 2002;10:1045–1056Yang J, Goetz D, Li JY et al. An iron delivery pathway mediated by a lipocalin. Mol Cell 2002;10:1045–1056Gómez R, Conde J, Scotece M et al. What’s new in our understanding of the role of adipokines in rheumatic diseases? Nat Rev Rheumatol 2011;7:528–536Gómez R, Conde J, Scotece M et al. What’s new in our understanding of the role of adipokines in rheumatic diseases? Nat Rev Rheumatol 2011;7:528–536Flo TH, Smith KD, Sato S et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004;432:917–921Flo TH, Smith KD, Sato S et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004;432:917–921Devireddy LR, Hart DO, Goetz DH, Green MR. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell 2010;141:1006–1017Devireddy LR, Hart DO, Goetz DH, Green MR. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell 2010;141:1006–1017Nairz M, Haschka D, Demetz E et al. Iron at the interface of immunity and infection. Front Pharmacol 5: 2014:152Nairz M, Haschka D, Demetz E et al. Iron at the interface of immunity and infection. Front Pharmacol 5: 2014:152Srinivasan G, Aitken JD, Zhang B et al. Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxininduced sepsis. J Immunol 2012; 189:1911–1919Srinivasan G, Aitken JD, Zhang B et al. Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxininduced sepsis. J Immunol 2012; 189:1911–1919Zhao H, Konishi A, Fujita Y et al. Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism. Cell Host Microbe 2012;12:705–716Zhao H, Konishi A, Fujita Y et al. Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism. Cell Host Microbe 2012;12:705–716Mishra J, Ma Q, Prada A et al. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14 (2003), pp. 2534-2543Mishra J, Ma Q, Prada A et al. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14 (2003), pp. 2534-2543Dent CL, Ma Q, Dastrala S et al. Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. Crit Care 11 (2007), p. R127Dent CL, Ma Q, Dastrala S et al. Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. Crit Care 11 (2007), p. R127Malyszko J, Bachorzewska-Gajewska H, Sitniewska E et al. Serum neutrophil gelatinase- associated lipocalin as a marker of renal function in non-diabetic patients with stage 2–4 chronic kidney disease. Ren Fail 30 (2008), pp. 625-628Malyszko J, Bachorzewska-Gajewska H, Sitniewska E et al. Serum neutrophil gelatinase- associated lipocalin as a marker of renal function in non-diabetic patients with stage 2–4 chronic kidney disease. Ren Fail 30 (2008), pp. 625-628Ko GJ, Grigoryev DN, Linfert D et al. Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI to CKD transition. Am J Physiol Renal Physiol 298 (2010), pp. F1472-F1483Ko GJ, Grigoryev DN, Linfert D et al. Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI to CKD transition. Am J Physiol Renal Physiol 298 (2010), pp. F1472-F1483Aghel A, Shrestha K, Mullens W et al. Serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure. J Card Fail 16 (2010), pp. 49-54Aghel A, Shrestha K, Mullens W et al. Serum neutrophil gelatinase-associated lipocalin (NGAL) in predicting worsening renal function in acute decompensated heart failure. J Card Fail 16 (2010), pp. 49-54Viau A, El Karoui K, Laouari D et al. Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. J Clin Invest 120 (2010), pp. 4065-4076Viau A, El Karoui K, Laouari D et al. Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. J Clin Invest 120 (2010), pp. 4065-4076Nickolas TL, Barasch J, Devarajan P. Biomarkers in acute and chronic kidney disease. Curr Opin Nephrol Hypertens 2008; 17: 127–132Nickolas TL, Barasch J, Devarajan P. Biomarkers in acute and chronic kidney disease. Curr Opin Nephrol Hypertens 2008; 17: 127–132Meldrum KK, Hile K, Meldrum DR et al. Simulated ischemia induced renal tubular cell apoptosis through a nuclear factor-κB dependent mechanism. J Urol 2002; 168: 248–252Meldrum KK, Hile K, Meldrum DR et al. Simulated ischemia induced renal tubular cell apoptosis through a nuclear factor-κB dependent mechanism. J Urol 2002; 168: 248–252Mishra J, Mori K, Ma Q et al. Neutrophil gelatinaseassociated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 2004; 24: 307-315Mishra J, Mori K, Ma Q et al. Neutrophil gelatinaseassociated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 2004; 24: 307-315Flo TH, Smith KD, Sato S et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004; 432: 917–921Flo TH, Smith KD, Sato S et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 2004; 432: 917–921Mitsnefes M, Kathman T, Mishra J et al. Serum NGAL as a marker of renal function in children with chronic kidney disease. Pediatr Nephrol 2007; 22: 101-108Mitsnefes M, Kathman T, Mishra J et al. Serum NGAL as a marker of renal function in children with chronic kidney disease. Pediatr Nephrol 2007; 22: 101-108Bolignano D, Coppolino G, Campo S et al. Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients. Nephrol Dial Transpl 2008; 23: 414-416Bolignano D, Coppolino G, Campo S et al. Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with severity of renal disease in proteinuric patients. Nephrol Dial Transpl 2008; 23: 414-416Kwon O, Phillips CL, Molitoris BA. Ischemia induces alterations in actin filaments in renal vascular smooth muscle cells. Am J Physiology Renal Physiology 2002. Vol. 282: 1012–1019Kwon O, Phillips CL, Molitoris BA. Ischemia induces alterations in actin filaments in renal vascular smooth muscle cells. Am J Physiology Renal Physiology 2002. Vol. 282: 1012–1019Kraydaschenko OV, Abramov AV, Dolinnaya MA. Role of biomarkers in estimation of renal tubulointerstitial tissue damage in patients with chronic glomerulonephritis. Lik Sprava 2015; (3- 4): 61-65Kraydaschenko OV, Abramov AV, Dolinnaya MA. Role of biomarkers in estimation of renal tubulointerstitial tissue damage in patients with chronic glomerulonephritis. Lik Sprava 2015; (3- 4): 61-65Bolignano D, Lacquaniti A, Coppolino G et al. Neutrophil gelatinaseassociated lipocalin reflects the severity of renal impairment in subjects affected by chronic kidney disease. Kidney Blood Press Res 2008; 31: 255–258Bolignano D, Lacquaniti A, Coppolino G et al. Neutrophil gelatinaseassociated lipocalin reflects the severity of renal impairment in subjects affected by chronic kidney disease. Kidney Blood Press Res 2008; 31: 255–258Bolignano D, Coppolino G, Lacquaniti A et al. Pathological and prognostic value of urinary neutrophil gelatinase-associated lipocalin in macroproteinuric patients with worsening renal function. Kidney Blood Press Res 2008; 31(4):274-279Bolignano D, Coppolino G, Lacquaniti A et al. Pathological and prognostic value of urinary neutrophil gelatinase-associated lipocalin in macroproteinuric patients with worsening renal function. Kidney Blood Press Res 2008; 31(4):274-279Munna LP, Rekha S, Ravi M et al. Prognostic significance of urinary NGAL in chronic kidney disease. International Journal of Nephrology and Renovascular Disease 2015; 8; 139- 144Munna LP, Rekha S, Ravi M et al. Prognostic significance of urinary NGAL in chronic kidney disease. International Journal of Nephrology and Renovascular Disease 2015; 8; 139- 144Вознесенская ТС, Бершова ТВ, Сергеева ТВ. Липокалин как маркер хронической болезни почек у детей со стероидрезистентным нефротическим синдромом. Российский педиатрический журнал 2013; 5: 20-25 [Voznesenskaya TS, Bershova TV, Sergeeva TV. Lipocalin as a marker of chronic kidney disease in children with steroid- resistant nephrotic syndrome. Rossijskij pediatricheskij zhurnal 2013; 5: 20-25]Вознесенская ТС, Бершова ТВ, Сергеева ТВ. Липокалин как маркер хронической болезни почек у детей со стероидрезистентным нефротическим синдромом. Российский педиатрический журнал 2013; 5: 20-25 [Voznesenskaya TS, Bershova TV, Sergeeva TV. Lipocalin as a marker of chronic kidney disease in children with steroid- resistant nephrotic syndrome. Rossijskij pediatricheskij zhurnal 2013; 5: 20-25]Миронова СА, Звартау НЭ, Конради АО. Поражение почек при артериальной гипертензии: можем ли мы доверять старым маркерам? Артериальная гипертензия 2016; 22 (6): 536-550 [Mironova SA, Zvartau NEH, Konradi AO. Kidney damage in hypertension: can we trust old markers? Arterial’naya gipertenziya 2016; 22 (6): 536-550]Миронова СА, Звартау НЭ, Конради АО. Поражение почек при артериальной гипертензии: можем ли мы доверять старым маркерам? Артериальная гипертензия 2016; 22 (6): 536-550 [Mironova SA, Zvartau NEH, Konradi AO. Kidney damage in hypertension: can we trust old markers? Arterial’naya gipertenziya 2016; 22 (6): 536-550]Kamijo-Ikemori A, Sugaya T, Kimura K et al. Urinary fatty acid binding protein in renal disease. Clin Chim Acta 2006; 374 (1-2): 1-7Kamijo-Ikemori A, Sugaya T, Kimura K et al. Urinary fatty acid binding protein in renal disease. Clin Chim Acta 2006; 374 (1-2): 1-7Satoh-Asahara N, Suganami T, Majima T et al. Urinary cystatin C as a potential risk marker for cardiovascular disease and chronic kidney disease in patients with obesity and metabolic syndrome. Clin J Am Soc Nephrol 2011; 6 (2): 265-273Satoh-Asahara N, Suganami T, Majima T et al. Urinary cystatin C as a potential risk marker for cardiovascular disease and chronic kidney disease in patients with obesity and metabolic syndrome. Clin J Am Soc Nephrol 2011; 6 (2): 265-273Malyszko J, Bachorzewska-Gajewska H, Malyszko JS et al. Serum neutrophil gelatinase- associated lipocalin as a marker of renal function in hypertensive and normotensive patients with coronary artery disease. Nephrology (Carlton) 2008; 13(2): 153-156Malyszko J, Bachorzewska-Gajewska H, Malyszko JS et al. Serum neutrophil gelatinase- associated lipocalin as a marker of renal function in hypertensive and normotensive patients with coronary artery disease. Nephrology (Carlton) 2008; 13(2): 153-156Blumczynski A, Soltysiak J, Lipkowska K et al. Hypertensive nephropathy in children – do we diagnose early enough? Blood Press 2012; 21 (4): 233-239Blumczynski A, Soltysiak J, Lipkowska K et al. Hypertensive nephropathy in children – do we diagnose early enough? Blood Press 2012; 21 (4): 233-239Aksan G, Inci S, Nar G et al. Serum neutrophil gelatinaseassociated lipocalin levels in patients with non-dipper hypertension. Clin Invest Med 2015; 38 (2): E53-62Aksan G, Inci S, Nar G et al. Serum neutrophil gelatinaseassociated lipocalin levels in patients with non-dipper hypertension. Clin Invest Med 2015; 38 (2): E53-62Bolignano D, Lacquaniti A, Coppolino G et al. Neutrophil gelatinase-associated lipocalin as an early biomarker of nephropathy in diabetic patients. Kidney Blood Press Res 2009; 32(2):91-98Bolignano D, Lacquaniti A, Coppolino G et al. Neutrophil gelatinase-associated lipocalin as an early biomarker of nephropathy in diabetic patients. Kidney Blood Press Res 2009; 32(2):91-98Yang YH, He XJ, Chen SR et al. Changes of serum and urine neutrophil gelatinase- associated lipocalin in type-2 diabetic patients with nephropathy: one year observational follow-up study. Endocrine 2009;36(1):45-51Yang YH, He XJ, Chen SR et al. Changes of serum and urine neutrophil gelatinase- associated lipocalin in type-2 diabetic patients with nephropathy: one year observational follow-up study. Endocrine 2009;36(1):45-51Kim SS, Song SH, Kim IJ et al. Nonalbuminuric proteinuria as a biomarker for tubular damage in early development of nephropathy with type 2 diabetic patients. Diabetes Metab Res Rev 2014 Nov;30(8):736-741Kim SS, Song SH, Kim IJ et al. Nonalbuminuric proteinuria as a biomarker for tubular damage in early development of nephropathy with type 2 diabetic patients. Diabetes Metab Res Rev 2014 Nov;30(8):736-741Pitashny M, Schwartz N, Qing X et al. Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. Arthritis Rheum 2007; 56(6):1894-903Pitashny M, Schwartz N, Qing X et al. Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. Arthritis Rheum 2007; 56(6):1894-903Suzuki M, Wiers KM, Klein-Gitelman MS et al. Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis. Pediatr Nephrol 2008; 23: 403–412Suzuki M, Wiers KM, Klein-Gitelman MS et al. Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis. Pediatr Nephrol 2008; 23: 403–412Hinze CH, Suzuki M, Klein-Gitelman M et al. Neutrophil gelatinase-associated lipocalin is a predictor of the course of global and renal childhood-onset systemic lupus erythematosus disease activity. Arthritis Rheum 2009; 60(9):2772-2781Hinze CH, Suzuki M, Klein-Gitelman M et al. Neutrophil gelatinase-associated lipocalin is a predictor of the course of global and renal childhood-onset systemic lupus erythematosus disease activity. Arthritis Rheum 2009; 60(9):2772-2781

The authors declare that there are no conflicts of interest present.