nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2018-22-4-57-73nefr-518Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESМИКРОБИОТА КИШЕЧНИКА И ХРОНИЧЕСКАЯ БОЛЕЗНЬ ПОЧЕК. СООБЩЕНИЕ ПЕРВОЕCOLONIC MICROBIOTA AND CHRONIC KIDNEY DISEASE. MESSAGE ONEЛукичевБ. Г.LukichevB. G.

197022, Россия, Санкт-Петербург, ул. Л. Толстого, д. 17

Проф. Лукичев Борис Георгиевич, д-р мед. наук, кафедра пропедевтики внутренних болезней. Тел.: (812)-234-01-65

197022, Russia, St-Petersburg, L. Tolstoy st., 17, build. 54

Prof. Boris G. Lukichev MD, PhD, DMedSci, Department of propedeutics of internal diseases. Phone: (812)-234-01-65

РумянцевА. Ш.RumyantsevA. Sh.

197022, Россия, Санкт-Петербург, ул. Л. Толстого, д. 17

199106, Санкт-Петербург, 21-я линия В.О., д. 8а

Проф. Румянцев Александр Шаликович, д-р мед наук, кафедра факультетской терапии Тел.: +7 (812) 326-03-26

197022, Russia, St-Petersburg, L. Tolstoy st., 17, build. 54

199106 Russia, Saint Petersburg, V.O., 21 line 8a.

Prof. Alexandr Sh.Rumyantsev MD, PhD, DMedSci, Department of Faculty Therapy Phone: +7(812) 326-03-26

rash.56@mail.ruАкименкоВ.AkimenkoV.

197022, Россия, Санкт-Петербург, ул. Л. Толстого, д. 17

Акименко Вера, кафедра пропедевтики внутренних болезней, студент. Тел.: (812)-234-01-65

197022, Russia, St-Petersburg, L. Tolstoy st., 17, build. 54

Department of propedeutics of internal diseases. Phone: (812)-234-01-65

Первый Санкт-Петербургский государственный медицинский университетРоссияFirst Pavlov St.Petersburg State Medical UniversityRussian FederationПервый Санкт-Петербургский государственный медицинский университет Санкт-Петербургский государственный университетРоссияFirst Pavlov St.Petersburg State Medical University Saint Petersburg State UniversityRussian Federation2018210720182245773Copyright © Лукичев Б.Г., Румянцев А.Ш., Акименко В., 20182018Лукичев Б.Г., Румянцев А.Ш., Акименко В.Lukichev B.G., Rumyantsev A.S., Akimenko V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/518

Интерес к изучению роли желудочно-кишечного тракта в поддержании гомеостаза при хронической болезни почек является традиционным. Он послужил, в частности, отправной  точкой для создания энтеросорбентов. Однако, если ранее основное внимание было  обращено на механическое удаление ряда потенциально опасных биологически активных  веществ, то в последнее время предметом интереса стала кишечная микробиота. Первая  часть обзора литературы на эту тему посвящена вопросам терминологии, нормальной  физиологии микробиоты толстой кишки. Дана подробная характеристика дисбиоза. Отражены особенности  основных групп микроорганизмов. Представлены гипотетические и подтвержденные  взаимосвязи оси кишечник–почки. Обсуждены патогенетические механизмы влияния дисбиоза  толстой кишки на процессы местного и системного воспаления. Дебатируются влияния  дисбиоза на состояние паренхимы почек и его участие в прогрессировании ХБП.

Interest in studying the role of the gastrointestinal tract in maintaining homeostasis in chronic kidney disease is a traditional one. It served, in particular, as a starting point for the  creation of enterosorbents. However, if earlier the main attention  was paid to the mechanical removal of a number of potentially  dangerous biologically active substances, recently an intestinal  microbiota has become an object of interest. The first part of the  literature review on this topic is devoted to questions of terminology, the normal physiology of the colon microbiota. A  detailed description of dysbiosis is given. The features of the main  groups of microorganisms are reflected. The hypothetical and  confirmed interrelations of the intestine-kidney axis are presented.  The pathogenetic mechanisms of the colon dysbiosis influence on the processes of local and systemic inflammation are discussed. The  influence of dysbiosis on the state of the kidney parenchyma and its  participation in the progression of CKD are debated.

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The authors declare that there are no conflicts of interest present.