nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2013-17-1-20-41nefr-532Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESПОЧЕЧНЫЕ ТУБУЛЯРНЫЕ АЦИДОЗЫ В ПРАКТИКЕ «ВЗРОСЛОГО» НЕФРОЛОГА. СООБЩЕНИЕ I. РОЛЬ ПОЧЕК В РЕГУЛЯЦИИ КИСЛОТНО-ОСНОВНОГО ГОМЕОСТАЗАRENAL TUBULAR ACIDOSIS IN PRACTICE OF «ADULT» NEPHROLOGIST. COMMUNICATION 1. KIDNEYS ROLE IN ACID BASE HOMEOSTASIS REGULATIONКаюковИ. Г.KayukovI. G.

кафедра нефрологии и диализа

197022, Санкт-Петербург, ул. Л.Толстого, д. 17, корп. 54. Тел.: (812) 346-39-26; факс: (812) 234-91-91

kaukov@nephrolog.ruДобронравовВ. А.DobronravovV. A.

кафедра пропедевтики внутренних болезней

КучерА. Г.KucherA. G.

кафедра пропедевтики внутренних болезней

ЕсаянА. М.EssaianA. M.

кафедра нефрологии и диализа

СмирновА. В.SmirnovA. V.

кафедра пропедевтики внутренних болезней

Научно-исследовательский институт нефрологии, Санкт-Петербургский государственный медицинский университетRussian FederationСанкт-Петербургский государственный медицинский университетRussian Federation2013100120131712041Copyright © Каюков И.Г., Добронравов В.А., Кучер А.Г., Есаян А.М., Смирнов А.В., 20132013Каюков И.Г., Добронравов В.А., Кучер А.Г., Есаян А.М., Смирнов А.В.Kayukov I.G., Dobronravov V.A., Kucher A.G., Essaian A.M., Smirnov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/532

В работе кратко суммированы современные представления о транспорте кислот и оснований в почках и регуляции этих процессов. Обращено внимание на ряд недостаточно освещенных в отечественной научно-медицинской литературе вопросов: молекулярную структуру некоторых переносчиков, вовлеченных в данные процессы, роль локальных сенсоров рН, рСО2 и бикарбоната, особенности транспорта газов через клеточные мембраны и др. Сделана попытка показать, дефекты каких механизмов транслокации протонов и бикарбоната в почечных канальцах могут лежать в основе редких и своеобразных заболеваний – почечных тубулярных ацидозов.

This review briefly summarizes the current understanding about of acid-base transport in the kidney and the regulation of these processes. Attention was turned to range of questions which are deficiently observed in national science-medical literature: molecular structure of some transporters, involved in these processes, role of local pH, pCO2 and bicarbonate sensors, characteristics of gases transport through cell membranes etc. Was made an effort to show defects in which mechanisms of proton and bicarbonate translocation in renal tubules form the basis for rare and unique diseases – renal tubular acidosis.

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The authors declare that there are no conflicts of interest present.