nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical Universitynefr-58Research ArticleСтатьиБИОМАРКЕРЫ В ДИАГНОСТИКЕ ОСТРОГО ПОВРЕЖДЕНИЯ ПОЧЕК. СООБЩЕНИЕ IIBIOMARKERS IN THE DIAGNOSIS OF ACUTE KIDNEY INJURY. COMMUNICATION IIПролетовЯ. Ю.ProletovIa. Iu.yan.proletov@gmail.comСагановаЕ. С.SaganovaE. S.noemail@neicon.ruСмирновА. В.SmirnovA. V.noemail@neicon.ruЗверьковР. В.Zver'kovR. V.noemail@neicon.ruПервый Санкт-Петербургский государственный университет им. акад. И.П. ПавловаРоссияPavlov First Saint Petersburg State Medical UniversityRussian Federation2014011120141865158Copyright © Пролетов Я.Ю., Саганова Е.С., Смирнов А.В., Зверьков Р.В., 20142014Пролетов Я.Ю., Саганова Е.С., Смирнов А.В., Зверьков Р.В.Proletov I.I., Saganova E.S., Smirnov A.V., Zver'kov R.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/58

В последние несколько лет все большее внимание привлекает возможность использования биомаркеров в диагностике острого повреждения почек. Данный факт обусловлен рядом недостатков таких традиционных параметров, как концентрации креатинина и мочевины сыворотки крови, измерение темпа диуреза, которые, с одной стороны, зависят от ряда экстраренальных факторов, с другой - их изменение происходит на поздних, необратимых этапах повреждения почечной ткани. В данной статье проанализированы возможности использования ряда маркеров в ранней диагностике различных вариантов ОПП. В публикующейся второй части работы рассматривается возможность использования в качестве биомаркеров ОПП низкомолекулярных белков мочи (альфа1-микроглобулин, бета2-микроглобулин и др.), внутриклеточных ферментов, микро-РНК, а также панели нескольких маркеров.

In the past few years increasing attention attended to the possibility of using biomarkers in the diagnosis of acute kidney injury because of disadvantages of the traditional parameters such as serum creatinine and urea, diuresis measurement, which on the one hand depends on a number of extrarenal factors, on the other - they change occurs in the later, irreversible stages of renal tissue damage. This article analyzes the possibility of using a number of markers in the early diagnosis of different types of AKI. Second part of work discusses diagnostic value of such biomarkers as low molecular weight proteins (alfa1-microglobuline, beta2-microglobuline etc.), intracellular enzymes, micro-RNA as well as the ability of using several markers in one panel.

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The authors declare that there are no conflicts of interest present.